The effect of the drug is probabilistic, and the network it forms makes the drug only work on a limited number of people, and we make the network play an intrinsic role through a certain combination (prescription)

The body is a network formed by the coupling of different levels (cells-tissues-organs-systems), and the thinking concept of finding drugs (sequence matching) should be changed to looking for cells (free movement of the network), and through the transformation of the environment, the selective expression of the network is changed, just like the impact of physiotherapy on the body's rehabilitation, which is also a kind of epigenetics. www.biquge.infoStem cells are the driving force of the network, and the effect of our search for drugs may have to be converted to the influence of local stem cells, and chronic diseases such as arthritis may be a problem with the expression of stem cells, so that the growth rate of the body's network itself cannot keep up with the wear and tear between levels. Or directly use stem cells as drugs, i.e. as intrinsic can conform to the network. and even cultivating organs;

From the perspective of the network, the original drug treatment is the underlying design (the multi-level sequence matching of the network and the achievement of the game and equilibrium state between the levels), and the new drug treatment is the top-level design (using the reductivity of the original organism network, and stem cells provide the power of continuous network renewal)

False contrasts are the source of all suffering

The network structure of the nerve itself contains a certain amount of information, which is memory

Forxiga (dapagliflozin) tablets are used to treat type 2 diabetes, the drug may increase the risk of patients suffering from glandular cancer and bladder cancer, which shows that the effect of all drugs is networked, and we must establish an overall network of action, so that all side effects can be shown in the nature of the network, do not wait for the experiment

Mechanism of action: Selective reversible sodium-glucose cotransporter 2 (SGLT2) inhibitor. The precise effect on the molecular level, which can be combined in all parts of the body, so as to show certain intrinsic characteristics, such as headache and treatment, its essence is the selective expression of the network

Multi-level roles can have certain patterns emerging

chronic hepatitis C, oral nucleoside analogue polymerase inhibitors; Are the various inhibitors an intrinsic feature of the disease network?

Use the relationship between drugs to counteract side effects

Unlike traditional type 2 diabetes treatment drugs, Forxiga has a unique pattern of acting independently of insulin, selectively inhibiting SGLT2 in the kidneys, which can help patients excrete excess glucose from the urine. SGLT2 is a specially constructed glucose transporter distributed in the S1 segment of the proximal convoluted tubule of the kidney, and its physiological role is to promote the reabsorption of glucose in glomerular disease. Combine physiological networks to find the nature of disease networks

1. New active ingredient drugs; 2. New formulations (except those belonging to 9); 3. Drugs with new routes of administration; 4. Add drugs for new indications; 5. Drugs with new mechanisms of action or new indications emerging through a substantial increase in dosage; 6. By changing to sustained-release agents, the usage and dosage of new dosage forms have been greatly changed; 7 new potencies (except those belonging to 4); 8. Change the dosage (except for those belonging to 5); 9. 9 categories such as similar formulas

basic drug research and development; Can target selection (intrinsic nature of the network), drug candidates, blockade of blockers have a positive effect?

The role of receptors is an intrinsic feature of many biological behaviors, such as G proteins, G protein-coupled receptors; The sequence of action is intrinsic, such as proteins, polypeptides; Sequence intrinsic emergences of large-scale data based on omics; Large-scale molecular screening

monoclonal antibodies, certain sequence matching; From technology to therapy

The manufacture of drugs is essentially a chemical process, and the action of drugs is reflected in multiple levels, such as chemical concentration, elevation degree, osmotic pressure, (the first order of physics); Second-order chemistry is a network set of interactions. The combination of drugs is of the third order, and the expression of the wave function is a coupling of specific eigens through various constraints

Pharmacology is the basic role, the intrinsic effect of the network, its overall effect on the body. For example, atropine has different effects on different receptors of smooth muscle in various parts of the body, so as to show different effects, such as dry mouth and gastrointestinal disorders.

Various primato-effects, and anti-drugs, and even anti-drugs, is an act of the network

Reference neural network activation and inhibition of 1/0 of the formation of the overall network, collapse of different functions

Everything is dose-dependent, probability-related

The target is the intrinsic nature of a network, which is the embodiment of the fixed point principle. The combination of targets may be a new essence, and the combination of formulas is a model

Site of action, metabolic process, dose, solubility

The role of receptors and ligands is intrinsic: structural, sequence matching

Ion channel proteins and so on

β blockers, reducing the probability of heart disease and stroke, which corresponds to the intrinsic level

Finding targets through drugs

Mutual restraint is the effect of nature, and the dose can cause a change in the function

Large-scale data at the genome level enables the emergence of specific intrinsic features, the high-dimensional structure of a specific sequence can be ligands, etc., and a specific drug is a sequence match

The immune system is an intrinsic feature of a body's network, and according to the similarities between levels, it has evolved from a basic antibody and antigen matching to a complex system

Co-expression of multiple genes

Symptoms of the nervous system, respiratory system, cardiovascular diseases, etc. are intrinsic, heart rate, blood pressure, hormone secretion, and other vital activities

The diversity of antigens in molecular structure is an intrinsic feature of a particular network

For example, proton pump inhibitors are used to treat heartburn, which is acid reflux

We can use not only ligands but also receptors

The role of the network formed by biochemical pathways is the eigenpath formed by the probability change of the whole, and the eigenity of the latter is the change of topology, and the overall effect can only be played by applying a combined effect: the distribution of the central node and the general node according to the distribution of connectivity; sequence matching at the quantum level of the network; The intrinsic nature of the drug is the fixed point of matching

Large-scale accumulation of interactions from the bottom

It only makes sense if you are above the threshold of the distribution function

Science is the ideal state, and technology is the result of selective expression, which will have a certain distance between theory and application

The results of scientific research are probabilistic behaviors,

Use the market as a measure

It is necessary to formulate a hypothesis to explain a natural phenomenon, design and conduct scientific experiments, prove the hypothesis, write a thesis, write a project application, and get government money to make another round of discoveries

;