Chapter 43: The Beauty of Physiology VII
The maintenance of concentration is an intrinsic feature of the network, as is muscle tension. www.biquge.info It is a dynamic process (e.g., sodium influx and potassium outflow at resting potential), but this is the nature of the whole, and local changes are not balanced
Steady-state is nonlinear, but rather a closed loop, which can be seen as curvature, and is a high-dimensional structure. You need to maintain the balance of more objects
There are exceptions to anything, but it can be explained in the case of probabilistic networks, because of relativity, we have to accept the unobservable nature of probabilistic networks like wave functions, which, once observed, can only collapse to a specific path. Only absolutely acceptable relatively. Feedforward relative to feedback, humoral modulation relative to neuromodulation, and facilitation diffusion versus simple diffusion, but this is the overall distribution, and there may be different expressions for specific situations, which reflects the absolute existence of relativity. Active transport requires energy and protein channels relative to passive diffusion
Secondary transport is a resistant change in primary transport and is the achievement of coupling-
Lung surface chemicals are substances that change resistance to Laplace's law
The exchange of intracellular fluid and extracellular fluid is a global network, and there is a potential difference at this level (inner 2/3 outer 1/5). As a result, there are potential differences at other levels, making the exchange a trend similar to the increase of entropy, such as the exchange of blood in the network of different osmotic pressures in the lungs and kidneys
Steady-state is the operation of the whole, and the important relative proportions determine the behavior of the selective expression of the network. These multi-level behaviors require a combination of different levels, referring to the formation of economic society, specific rules such as energy minimization is intrinsic, but reality is the result of expression, and we have to consider the probability of the network in the frequency of large-scale data.
Physiology is composed of multiple levels, and regulation is also multi-level, the structure is more static, and the regulation is more dynamic, but in fact they are coupled, like a spiral. Because they are essentially selective expressions of the network, we just choose different perspectives to describe them, but then there is the coupling and traversal of the levels to achieve the result of ascending, that is, to understand the high-dimensional structure of the individual's physiology. The same applies to the relationship between structure and function, the relationship between the part and the whole
Disease is the result of a series of proportional changes, and the different sensations and detection results of people (such as dry mouth, general weakness) are its essence, and it is the relative proportion of different levels: the proportion of cells, organs, systems and even the whole, specifically the activation or inhibition of different key points (the different effects of different neurotransmitters of different receptors in different parts of the body, that is, their networks), and the essence of this network is the path collapse of feedback and so on. This is a coupled form of statistics and probability
Neurohumoral regulation is also a coupling, and collapse is also the collapse of the matrix expression of the probability of the network, i.e., linear summation: transport form (active-passive, endocytocytosis)
Combination of components of the membrane: lipids, proteins, sugars. At the same time, there is a certain sequence of symbols, that is, interfaces that can be recognized, which is the premise of hierarchical coupling
The regulatory axis is the selective expression of the hypothalamic-adenohypophysis-**** axis, which is a coupling of multiple levels of feedback to form a network. Organs such as the hypothalamus, pituitary gland, etc., are intrinsic
Quantum differentiation is 1/0, and the network formed by the combination is our world. Relativity is a relation, and proportionality determines behavior, i.e., selective expression. The nature of the opposite is the feedback of the whole
Regulation of blood pressure: output per wave, elasticity of the aortic wall, peripheral resistance, heart rate, ratio of circulating blood volume and vascular volume, these are the behaviors of the network, which are the opposing forces of two opposing forces, power and resistance, which can be converted into each other, which is also reflected in the regulation: transmitters, receptors and distribution, effects
The proportions of the different levels are coupled structures, like the different partial derivatives of differential equations, which are the basis of frequency and probability operations, the law of large numbers, the relationships revealed by Bayesian formulas, which can be reasonably inferred, correlations and regressions, the distribution of networks, and the degree of confidence as a weighting
Environment: Fluidity of liquids
The steady state of the environment is a dynamic equilibrium that enables the network to reorganize those circuits, logical circuits that are connected in series and parallel
The basic mode of activity of nerves is reflex, and the flow of body fluids is the flow of a wide range of transmitters, and it is a sublayer regulation with smaller granularity
The reflex arc consists of five basic links, namely receptors, afferent nerve fibers, nerve centers, efferent nerve fibers, and effectors, which are the basis of structuring
The feedback control system is a closed-loop system, which is loop control, which is the high dimension of the reflection arc.
Negative feedback keeps the body stable, positive feedback breaks the equilibrium and changes the direction of occurrence, but excessive is a pathological condition
The solute molecules in the high concentration area will have a net movement, diffusion, and potential difference to the low concentration area
Permeability, a measure of similarity between a substance and fat-solubility
Cell membranes are not pure lipid membranes, and their mosaic protein channels enable the transport, mixing, or coupling of ions
Selectivity, using its own energy, competition and saturation
The sodium pump is composed of a transmembrane A subunit (catalytic subunit) and a glycoprotein molecule (β subunit), the catalytic subunit has a binding point of Na+ and ATP, and has the activity, catalysis and regulation of ATPase
Ionic potential energy storage
In intestinal and renal tubular epithelial cells, the energy required for active transport of sugar still comes indirectly from the breakdown and combined transport of ATP
Characteristics of membrane receptor binding: (1) Specificity. (2) Saturation. (3) Reversibility.
It only takes a small amount of stimulation to exhibit some form of response, excitability
The spatial sum of excitation, additive
The different stages in the splice transfer process
;