"Sir, your application for the use of the equipment submitted on Wednesday was rejected, I am very sorry, please make an appointment for the next time in time. ”

Although the content of the words seemed to be an apology, the cold voice on the other end of the phone showed that the person who spoke was really insincere at all, which made Tian Lu's heart burn at the same time, and he had to sigh helplessly and sit back in the chair.

He thought about some things too simply.

There are thousands of researchers at the Scripps Research Institute, more than 200 professors, dozens of large and small research groups, and there are naturally many experiments to be carried out every day, which makes people's scalp tingle, but what he didn't expect was that in just one month, three applications for the use of equipment were rejected. Without exception, they all conflict with the plans of other researchers.

This week's appointments are full, and it will not be until next week at the earliest, so Tian Lu's experiment had to be reluctantly stopped.

The experiment he's doing now is only the initial stage of a two-year plan, but it's this initial stage, and he's been stuck here for three whole months!

The first two months of coming to Scripps Research Institute are training, training in the basic skills of experiments, how to use various instruments, etc. Although with the help of the system simulation implementation function, Tian Lu mastered these skills early, but he still had no choice but to accept the arrangement of the institute. After all, there was not a single resume on his resume that he had received similar training.

In the third month, after officially starting his own experiments, he encountered a series of unexpected situations that he had never imagined, and the rejection of the application for the use of the instrument was just one of them.

Once or twice is accidental, and if it happens a third time, then I'm afraid it's my own problem.

It was already time to get off work, and now that the results had been determined, Tian Lu had no energy, so he hastily cleaned up and walked out of the laboratory.

There are thousands of people in the institute, even if there are many people working overtime to do experiments, and there are many people who get off work on time, in the bustling flow of people, Tian Lu took out his bicycle, put on his helmet, and drove out of the gate of the institute.

In fact, there are many researchers who use bicycles to commute to work every day, not because of environmental protection, but mainly for the purpose of exercise. Researchers are busy with work, and many times they often soak in the laboratory for days for an experimental result, so many people use cycling to commute to exercise their bodies, killing two birds with one stone.

It takes about 50 minutes to ride a bicycle from the research institute to the rented house where Taro lives, and Taro is also a way to strengthen his physique.

On the slightly empty road, Tian Lu rode while carefully analyzing it in his mind.

The first step of his experiment was on pericytes.

Tian Lu's long-term goal is the mechanism of action of the blood-brain barrier, but this is a complex and huge topic, and in order to fully explain the complete system of the entire blood-brain barrier, there is too much work to be done in advance, and he can only do it step by step.

The main structure of the blood-brain barrier is the cerebral capillary endothelial cells, which are also surrounded by a continuous basement membrane. Outside the basal membrane, there are many astrocytes around the perivascular foot, which encloses about 85% of the surface of the cerebral capillaries. This forms a multi-layered membranous structure of brain capillaries, which constitutes a protective barrier to brain tissue. Pericytes are adjacent to astrocytes and have extremely complex cellular regulatory functions, such as regulating blood flow, promoting angiogenesis, migrating to endothelial cells, phagocytosis and antigen presentation, and stem cell function.

Among the cells that make up the cerebral capillaries, endothelial cells mainly form tight junctions and are responsible for mediating permeability and signal transduction, while pericytes exchange ions and small molecules with endothelial cells through gap junctions. Plasma cell protrusions contact the basement membrane in a Peg-Socker manner and interface with astrocytes and peripheral blood vessels. It can communicate with endothelial cells and other cells of the neurovascular unit (neurons, astrocytes, etc.) through direct contact and through autocrine and paracrine signaling molecules.

In reality, although there are some discoveries about the role of pericytes on the blood-brain barrier, they are not systematic and accurate, and the first step of Tianlu's research is to accurately and completely elaborate the mechanism and specific content of pericytes. The first step in the experiment is to identify the molecular markers used to screen and identify pericytes. At present, the commonly used proteins including α-**A, 3G5, NG2, etc. are cell surface proteins, but the specificity needs to be further confirmed.

In the medical literature support system, the research four years later has elaborated on the experimental process and results, and all Tian Lu has to do is to reproduce it.

But this simple reproduction has been interrupted several times!

"There must be something wrong with your own arrangement!"

Tian Lu thought secretly.

It is true that there are times when the appointment of an instrument may be cancelled, because it is necessary to prioritize the experiments of certain experts, but in most cases, fairness can still be guaranteed. Especially Tian Lu's current experiment, all that is needed is some conventional instruments, which are not very high-end, so it has been rejected three times, and I am afraid that it is really a problem with the time arrangement.

Generally speaking, Tianlu makes an appointment three days in advance, but as it stands, I'm afraid it will take at least a week or so in advance!

For the entire research content of the blood-brain barrier, the scientific research support system has given a complete plan and a very detailed process, but the specific test schedule and other contents still need to be handled by the researchers themselves.

In a sense, the two years in the institute have been a hurdle for the field.

Just like the application of system functions in clinical practice, the application of scientific research support systems in reality also needs to be familiar and mastered by Tian Lu through practice.

In the early days of the research, Tian Lu was still just a person, and the most important thing was the process of experimentation. But in the meantime, he had to encounter many problems that were impossible in systematic experiments. For example, the application of experimental raw materials, the application of experimental equipment, the arrangement of experimental progress, and the report to the chief officer。。。。。。

If Tian Lu has made certain achievements and sees a bright future, the institute will inevitably increase investment, and if there are technical personnel or even researchers involved, then as the leader, he will have to do more! For example, arrange the work of the personnel, coordinate the work of various groups, and control the progress of all the work。。。。。。

The scientific research plan given by the system is undoubted, systematic and organized, but it is precisely because it is too systematic that it is destined to be impossible to carry out on its own.

In fact, any important research result in the medical field is the accumulation of many years of achievements of countless scientific researchers!

Just like the mechanism of the blood-brain barrier, although it has been fully elaborated in the future, it relies on hundreds of years of accumulation and precipitation!

From the discovery at the beginning of the twentieth century to the complete elucidate of its mechanism twenty years later, it took more than 100 years, countless scientific researchers, countless research institutions, and even countless funds to invest in it, and finally formed a complete set of theories!

Although Tian Lu had the foresight and could use the simplest and most direct method to reach the end, this straight-line process was still not something that could be completed by one person or even a small team.

"There's so much to learn!"

Tian Lu sighed secretly. Whether as a physician or as a scientific researcher, with the help of the system, he can stand on the top of the world in the shortest time, but in order to transform the knowledge of the system into results in the real world, he must get more in reality!

It requires huge resources, effective management, and adequate support。。。。。。

These are all things that you can't get in the system!

"Come up with the results as quickly as possible, and then apply to form a small team! Then, learn how to manage a research group, or even further, learn how to manage a research project。。。。。。 ”

Tian Lu shook his head with a wry smile, thinking secretly.

If possible, Tian Lu really only wants to be a pure technician, and even in the future, he hopes to position himself in the position of academic leadership, just to control the content of research. Only in this way can you avoid too much distraction, so as to maximize the role of the system and make the results you want as quickly as possible.

But, of course, in reality, this is not possible.

To put it bluntly, it's still not strong enough!

If he has enough weighty results to publish, and if his research can make people see a bright future, then there are naturally countless enterprises or research institutions that will take the initiative to rush forward and provide sufficient resource support. When the time comes, he will be able to assemble his own research team, hire experienced project managers, and even get a large number of scientific research equipment at his disposal。。。。。。

All of this must have a premise: Tian Lu must come up with exciting research results!

"Speed up!"

Tian Lu saw the apartment building he rented from afar, lowered his head sharply, leaned down, and the pedals of the bicycle spun rapidly like Hot Wheels。。。。。。