Splitx Institute, Office of the Head of the Department of Neurobiology.

Professor Bruce looked at the materials in his hand, his expression was extremely focused, his eyes slowly moved line by line on the paper, and it took him a long time to turn a page.

"Jingle bell。。。。。。 ”

After the phone on the table rang several times, he grabbed the microphone extremely impatiently, listened to a few words, and then said in a deep voice: "Let him wait for half an hour。。。。。。 Come back in an hour!"

After speaking, he put down the phone with a "snap", and immediately turned his gaze back to the information in his hand.

After another ten minutes, Professor Bruce put down the materials in his hand with a solemn face, and looked at the young man sitting on the chair in front of him in amazement: "This is your research results in the past six months?"

"Yes, sir!"

Tian Lu moved his body slightly and replied solemnly.

"Do you have a detailed record of the experiment?" Professor Bruce asked urgently.

"Of course, sir!"

Tian Lu hurriedly took out a thick stack of printer paper from his leather bag, got up and handed it to Professor Bruce. As soon as he grabbed the experimental records of Tian Lu, Professor Bruce almost couldn't wait to look through them.

The sound of turning pages immediately became the only sound in the quiet office!

"God!"

After flipping through the last page of paper, Professor Bruce looked up after a moment of distraction and exclaimed, almost in a low voice, "Do you know what this paper of yours means?"

"Yes, sir. ”

Tian Lu nodded.

"No! you don't know!"

Tian Lu raised his head a little stunned, watched Professor Bruce push away the leather chair behind him, and stood up excitedly and exclaimed: "If you knew the significance of this paper, your performance would definitely not be so calm!"

Waving the experimental record data in his hand, Professor Bruce's heart swelled with irrepressible excitement and impulse!

If Tian Lu's article "A Comparative Study on the Role of Several Molecular Markers in the Screening and Identification of Pericytes" three months ago only made him realize the potential of this young man and deserved more financial support, then the article "The Effect of Pericellular Autocrine Signaling Molecules on Endothelial Cells in the Pericyte/Endothelial Cell Co-culture System" in his hand is even worthy of him to set up a research team for Tian Lu!

After a moment's hesitation, Professor Bruce asked aloud, "How sure are you that you are based on the final predictions of the paper, how many people will be needed, and how long will it take?"

"Six laboratory technicians, sufficient financial support and the right to use the equipment, then I am sure that the results will be available within two months!"

"Good!"

Professor Bruce waved his right arm fiercely, and said decisively: "In two days, no! The technicians you asked for will be in place tomorrow! In addition, I will inform you that the supply of your laboratory animals and the use of equipment have priority!"

"Thank you very much, sir!"

The excitement that had been suppressed in my heart could no longer be hidden, Tian Lu stood up in ecstasy, and said solemnly: "I promise you that I will give you a perfect answer within two months!"

"Hmm!"

Professor Bruce nodded heavily, shook the materials in his hand and said, "You go back and prepare first, these materials will be placed here for me, and when the experiment is successful, they will be sent for publication together!"

Hearing this, he nodded gratefully at the other party, and Tian Lu immediately got up and walked out. Having received the perfect reply, he can't wait to prepare for the next two months of research projects.

Looking at Tian Lu who disappeared in the doorway, Professor Bruce walked quickly back and forth in the office for a moment before returning to his place and slowly sitting down.

He couldn't help but look at the stack of printer paper in his hand again, and his eyes sparkled: this is a new discovery that is no worse than the new vascular growth factor and the small molecule synthesis that controls the fate of embryonic stem cells!

It is really hard to believe that in less than ten months, that young man has made such tremendous achievements! There is not much innovation in the research method, nor does it use very sophisticated instruments and equipment, but from an angle that ordinary people can hardly imagine, Tian Lu actually found an inconspicuous road from the fog!

At least from Professor Bruce's years of experience and sophisticated vision, the chances of this road reaching the end of the road are extremely high!

On the first day I met Tian Lu, when I saw his research plan, Professor Bruce never imagined that he would get to where he is today. It's just that for a neurosurgery resident, the work in the laboratory is more about cultivating independent scientific research qualities, and the proposal does have a certain feasibility, so out of the idea of encouraging young people, Professor Bruce agreed to Tian Lu's research plan.

I didn't expect him to do it so quickly!

If successful, it will add to the honor roll of the Department of Neurobiology at the Sprex Institute!

。。。。。。

Back in his laboratory, Tian Lu couldn't wait to enter the system in his mind, and while referring to the research plan that had been prepared, he crackled on the computer in reality.

He didn't expect that this matter would go so smoothly today, and he had planned to successfully persuade Professor Bruce to give more financial support through this paper, after all, for a resident in training, his research funding is limited, and whether it is experimental materials or experimental animals to be used in the future, its value is very high. But what he didn't expect was that as soon as he saw the paper he had written, Professor Bruce immediately gave such great support!

Ten months, no, seven months to be precise, without distractions, Tian Lu successfully completed the most preliminary research.

For more than 100 years, many scientists and pharmaceutical companies have been researching how to break through the blood-brain barrier, so that they can attach to receptors and other molecules, so as to break through. But what Tian Lu has to do is to directly control the blood-brain barrier and let it relax the shielding effect on certain substances, so as to achieve the same result!

It's easy to say, but it's certainly not so simple to do.

In fact, people have thought of this for a long time in reality, including the study of pericytes. For example, it has been found that the smooth muscle contraction protein expressed by pericytes, as well as **F-β, etc., can play a certain role in the permeability of the blood-brain barrier, but they either have strong side effects or are uncontrollable, and do not have much practical significance.

With the help of the system, Tian Lu directly ruled out countless possibilities, skipped thousands of experiments, and directly found the final result: a newly synthesized compound that can stimulate pericytes to express autocrine signaling molecules, so as to successfully open the blood-brain barrier!

Tian Lu excitedly tapped on the keyboard, page by page to type out the follow-up test plan: to establish an endothelial cell-pericyte-astrocyte co-culture model to simulate the anatomical structure of the blood-brain barrier, to establish an experimental mouse animal model, to carry out an experiment on the opening time of the blood-brain barrier by compound concentration, and to test the list of substances that can pass through the blood-brain barrier。。。。。。

Tianlu must speed up the progress of follow-up tests as much as possible!

At the prompting of the medical literature support system, Tian Lu learned that just a few months later, "Nature. In an article published in the journal Neuroscience, researchers at Cornell University have found that adenine nucleoside receptors, a molecule produced in mice, can control the entry of large molecules into the brain, and when adenine nucleoside receptors are activated on the cells that make up the blood-brain barrier, a channel into the blood-brain barrier will be established. They also found that Lexiscan, an adenine nucleoside-based drug approved by the U.S. Food and Drug Administration, can easily open pathways through the blood-brain barrier. Next, they plan to explore ways to deliver drugs for brain cancer and better understand the physiological mechanisms behind adenine nucleoside receptors controlling the blood-brain barrier.

Although the ideas of the two studies are not the same, the results are not consistent, and future research has shown that this way of Tian Lu is a more effective and safe way, he still does not dare to be careless.

This is a series of studies, to be able to open the blood-brain barrier through the control of pericytes is only the first step, if you want to make this theory more systematic, or even directly applied to the clinic, then the follow-up research content is extremely huge: after obtaining the results and data of this compound affecting the opening and closing of the blood-brain barrier, it is necessary to further study its mechanism of action and study the mechanism of action of pericytes on the blood-brain barrier.

Of course, there is also the mechanism of action of astrocytes on the blood-brain barrier, the mechanism of action of endothelial cells on the blood-brain barrier, etc。。。。。。

As the research itself, it is difficult to have any economic benefit for Tian Lu, after all, he uses existing substances and does not create a new substance independently.

But the sooner you publish it, the sooner you can get stronger support!

After all, basic research has always been supported by the state, or rather, by donations. For example, if Tian Lu's research results are successfully published, then you can definitely apply for more support from the institute, and even many pharmaceutical companies will take the initiative to give a large amount of research funding!

Successfully open the blood-brain barrier, those pharmaceutical companies are the biggest beneficiaries in the end.

And even if you don't get profit, you can definitely get a name for it!

For a researcher, reputation is more important than anything else, as long as there is enough weight, then the future research facilities, equipment, and personnel support, naturally do not have to worry.

What's more, these are only a small part of what Tian Lu can do, as long as there is enough support, there are too many follow-up big killing weapons。。。。。。