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"Shocking, Bayer Pharma of Germany has developed a new drug that can cure the stubborn disease of sepsis."

"The hand of God appears, and sulfonamides save lives."

"The ultimate magic weapon for human beings to defeat germs, the miraculous performance of Bayer sulfadine tablets."

In addition to professional magazines such as The Lancet, even mass media such as The Times and Paris Express began to report on the birth of a new drug, which is the second major human development of the fight against germs after the introduction of erythromycin and other macrolide drugs. Although it is not a product developed by Bayer, the sales authorization in Europe is enough to make Bayer the second largest pharmaceutical manufacturer in Europe. Of course, Birmingham Robin Pharmaceuticals was unhappy with such a competitor, even after Earl Shawn granted them the British right to sell the miraculous sulfonamide drug. Positive is their usual style at sea, and sharing with others is not the style of English gentlemen, unless they have no advantage.

The clinical application of sulfonamides has been rapidly developed, it has a wide antibacterial spectrum, and the efficacy is certain, the nature is stable, the use is simple, the price is cheap, and it is convenient for long-term storage, so it has become a large class of drugs second only to erythromycin in the shortest possible time, of course, after the synthesis of high-efficiency, long-term and broad-spectrum new sulfonamides and antibacterial synergists produced by standard pharmaceuticals, it will make the clinical application of sulfonamides have a new broad future.

"Sulfonamides inhibit gram-positive bacteria and some negative bacteria. Bacteria that are highly susceptible to it are: streptococcus, pneumococcus, Salmonella, Corynebacterium pyogenes, Escherichia coli. It has inhibitory effect on staphylococcus, pneumobacterium, pasteurella, anthrax, Shigella, Arizona bacteria, etc., and also has an effect on some protozoa that harm poultry. "In the medical society of the French Academy of Sciences, there is a scientific newspaper on sulfonamides, and the most famous doctors and chemists in France are listening to the newspaper gào from Germany.

"The main effect of sulfonamides is to inhibit the reproduction of bacteria, because some bacteria need to use p-aminobenzoic acid when they grow. Aminobenzoic acid and dihydroterenophene synthesize dihydrofolate under the action of dihydrofolate synthase; Dihydrofolate is reproduced by dihydrofolate reductase, and tetrahydrofolate is generated; Tetrahydrofolate is further formed into activated tetrahydrofolate, that is, coenzyme F, which can transfer a carbon group to participate in the synthesis of purines and pyrimidine nucleotides. Because the chemical structure of sulfonamides is very similar to aminobenzoic acid, it can compete with aminobenzoic acid for dihydrofolate synthase, hinder the formation of dihydrofolate, and ultimately affect the synthesis of bacterial nucleoprotein, thereby inhibiting the growth and reproduction of bacteria. ”

The report also mentions the limitations of sulfonamides, that is, bacteria that are sensitive to sulfonamides can acquire resistance in vitro and in vivo, and after developing resistance to one sulfonamide, they often develop cross-resistance to other sulfonamides, but sulfonamide-resistant bacteria are still sensitive to other antimicrobial drugs. Translated into human terms, if you take sulfonamide and it doesn't work, even if you try other medicines, sulfonamides will not cause side effects on other medications.

It is conceivable that in the small medicine box brought by the family, sulfonamides can be regarded as an important member of the permanent army. When people have inflammation, such as urethritis, enteritis, and respiratory diseases, they often think of "eat some sulfonamides" first. It is true that sulfonamides have the advantages of quick effect, definite efficacy and low price in the treatment of inflammation, but compared with other drugs, sulfonamides are more "exquisite" drugs, and once these "exquisite" are ignored, they will make you have more pain and trouble.

When taking ordinary medicines on a daily basis, it is generally known that dào should drink a large glass of water in order to take the medicine smoothly, but when taking sulfonamides, it is not a large glass of water that can be used. Wu Daguan also said that since the solubility of sulfonamides in urine is very small, in order to increase its solubility, the best way is to drink as much water as possible, so as to reduce the concentration of the drug in the urine by increasing the amount of urine. Otherwise, the drug is easy to form crystals in the renal tubules, renal pelvis, ureters, bladder, etc., and can eventually cause side effects such as low back pain, hematuria, urinary tract obstruction, and urinary closure due to its mechanical stimulation. Therefore, if you want to achieve better and faster results, you should drink as much water and urinate as much as possible while taking the drug.

In order to prevent stones that may be caused by long-term use of sulfonamides, it is also a good idea to take sodium bicarbonate (baking soda tablets) at the same time. The addition of sodium bicarbonate can not only alkalize the urine and enhance the efficacy of sulfonamides, but also prevent the crystallization of sulfonamides in the urine that may occur with long-term use of sulfonamides.

Taking sulfonamides, in addition to the possibility of growing small stones in the body, can also poison you if you are not careful in the dosage. Because some patients feel that sulfonamides have a good effect, they often take two more tablets or two more days on their own, thinking that this can consolidate the effect of the drug, but the consequences of this may lead to drug accumulation poisoning. Therefore, patients should not increase the dosage, increase the number of doses or prolong the course of medication during the medication period. It is best not to take the drug for more than 5 days to prevent aggravating the toxic side effects of the drug.

In addition, sulfonamides also have the characteristics of the same qi branch, that is, there is cross-allergy between brothers and sisters, such as sulfathiazole, sulfadiazine, cotrimoxazole, etc., if the patient will be allergic to this sulfonamide, then the other will be allergic. Bacteria also have cross-resistance to sulfonamides, that is, diseases that cannot be cured by sulfonamides, and other sulfonamides are also incompatible with this bacteria. In addition, it is important to note that sulfonamide allergy is prone to fixed drug eruptions in some parts, such as redness and blistering of the genitals.

Because sulfonamides can inhibit the growth of E. coli and hinder the synthesis of B vitamins in the intestine, if you need to take sulfonamides for more than a week, you should take B vitamins at the same time to avoid nutritional deficiencies.

This explanation makes it easy for physicians to use sulfonamides correctly, and it also gives Standard Pharmaceuticals and Bayer a good reputation in their respective regions, after all, sulfonamides are their advantages in terms of efficacy and price. If side effects are avoided, sulfonamides can still be widely accepted by doctors and patients. Of course, Birmingham Robin Pharmaceutical did not let go of any British colonies, and soon from the southwest coast of Australia to the ice and snow of Greenland, sulfonamides became the first choice of doctors, unless there was no cure for five days, they would change to other products, and even patients knew that Dào first bought a little sulfadidine or neoxinazole to eat, of course, if it was combined with another product from Bayer, the effect would be more obvious, that is, diacetylmorphine, or heroin in human terms.

A few years ago Bayer chemist Felix ?? Hoffman synthesized a substance called diacetylmorphine in the lab. The analgesic effect is much higher than that of morphine (11 days ago, he had just succeeded in making aspirin into a drug). The name Heroin is registered by Bayer Pharmaceuticals, which may be derived from the German word heroisch, which means hero. His bosses were overjoyed, believing it could be an alternative to morphine, an addictive painkiller. When it was confirmed that some of the fish, seahorses and cats used for the experiment were still alive after swallowing these drugs, the company's family members, including the children, also began to try to take them, and no one was poisoned or addicted. Less than a year after its synthesis, the company launched it without conducting thorough clinical trials.

Both Alber and the shareholders of Bayer AG considered the invention of the substance to be a "heroic" deed, hence the name ("heroin" means "hero" in German). The story then comes the most ridiculous page in the history of medicine. Even until the thirties of the twentieth century, Bayer sold high-purity heroin. The world has hailed the potency and versatility of this powerful and versatile drug, and thousands of patients have rushed to take it. It was much later that it began to be seen as a diabolical drug.

When the drug was launched, it was advertised as non-addictive morphine, and Bayer had been used as the main ingredient in children's cough medicine, so when it was later discovered that the drug would be converted into morphine in the liver, it would be a great embarrassment for Bayer Pharmaceuticals. Of course, Wu Chenxuan's classmates will not solve this mystery for Mr. Alber, after all, the road to wealth is like killing his parents, and Wu Chenxuan still expects him to earn more marks for Shandong.

"Are you going to pay us the mark? US dollars or British pounds. At a newspaper in Frankfurt, a balding editor sipped Cuban Amber coffee with double cream. Opposite him was a middle-aged white man in a trench coat, who looked like a Hungarian or bohemian, and from his weathered face, he did not look like a wealthy man who could afford a fortune.

"Mr. Editor-in-Chief, I think you have misunderstood. I think you, as a media hero with a sense of justice, will be interested in some of the materials I have provided, because this involves a huge conspiracy, and someone is obtaining scientific and technological achievements that should belong to our country through improper means such as plagiarism and theft. This middle-aged man opened his mouth with a big bucket of truth, and what he said was a big bucket of righteousness, but our editor-in-chief was already a little impatient, could it be that the other party was a fledgling chick, and he wanted to make waves in the newspaper without a little truth?

"As a token of our respect, we give you a little souvenir." Probably already seeing that the editor-in-chief's attitude was beginning to get bored, the man took out a box, a delicate wooden box two and a half inches long and an inch wide, which looked like the packaging of a gold pen.

If it is a gold pen made by the Swiss, it may be worth a few hundred marks, and the editor-in-chief opened the box and could see that it was indeed a gold pen, but there was no brand. Looking at the golden impostor, the editor-in-chief's mind is about to boil, who dares to entertain the family. Just before turning his face, the experienced editor-in-chief saw that the middle-aged man's face seemed to have a flash.

No, no one takes business as a child's play, isn't this glittering? Pretending to be playing, I feel that the weight is not right, let alone the pen, even the steel pipe is not this weight. Twisting the cap of the pen, but not moving, looking at the so-called golden pen that was poured as a whole, I had a trace of realization in my heart, it is really a veritable golden pen.

The other party seemed to unconsciously click on the wooden box, and the editor-in-chief picked up the wooden box with his hand, and almost didn't flash to his wrist for the first time, and the weight of this box is not right, isn't it?

Seeing that the editor-in-chief was already clear, the middle-aged man politely put down the manuscript and left. Only the editor-in-chief was left very expert in identifying the varieties of metal with his teeth, looking at the metal box that was torn open and the gold pen that looked like a model, the editor-in-chief was ecstatic, no less than 800 grams of gold, and there was no 10,000 marks of purity that could not be taken. It was a long time before the enthusiastic editor-in-chief remembered the manuscript.

"Is the poisoning of sulfonamides a cure or a poison?"

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