"Quinine, uh, was invented in 1820."

"Aspirin,, came out in Germany a few years ago."

Wu Chenxuan got up in the morning and began to calculate, the current Shandong Chamber of Commerce and his own business has entered a bottleneck period, and the possibility of another outbreak in the short term is zero, but it may be possible to overthrow the Qing court with only 100,000 elite soldiers, and it can be tried to get rid of Yuan Datou with some means, but in the face of the upcoming World War I and the Japanese who are eyeing him, Wu Chenxuan also feels that his strength is stretched. Aircraft, tanks, aircraft carriers, of course, are loved by everyone, but the purse is not strong. Shandong, which does not have much accumulation, now looks thriving, but it can't withstand overdraft, and Wu Chenxuan, who is looking for a way to make money, remembered a famous saying: "Except for those who rob the road, they sell medicine." Of course, Wu Chenxuan knows the profits from selling drugs, and the partners are also easy to do, whether it is Pfizer or AstraZeneca, they can get on the line through the relationship between Britain and the United States, but the Allies of World War I are much worse, and Shandong will definitely not accompany Germany to hell at that time, so as a member of the Entente, Wu Chenxuan's only face feels that it is really not good to directly export materials to the Germans (in fact, he is afraid that Britain and France will know about the chicken and eggs).

It's easy to make money selling drugs in Germany, the head snake is ready-made, this is not after yesterday's cocktail party, Wu Chenxuan in addition to gaining countless eyeballs, and Wang Damei's favor, but also got some invitations from German companies, including a future German drug boss - Bayer, although it is still a second-rate local pharmaceutical company.

Bayer AG was founded in Germany in 1863 by Friedrich Bayer, and the company's headquarters are located in Leverkusen, Germany. On March 6, 1899, Bayer acquired the registered trademark of aspirin, which later became the most widely used and well-known pharmaceutical brand in the world and brought Bayer unimaginable profits. In 1925, the company merged with several other chemical companies to form Farben Chemical Industries, which was dismantled after the war. In 1951, it became an independent successor company called Bayer Pigment AG, and in 1972 it was named "Bayer AG".

Bayer's main products today are aspirin and heroin (yes, it's the drug, but it was a legal drug at the time, and it was even a universal drug, so if you had a cough or a fever, the doctor would usually prescribe you a dose). Heroin can be bought and sold in pharmacies like Contec, and I wonder if the drug dealers who will be in danger in the future will die of shame) and so on. They don't yet know how big the business they will be in the future.

The current Bayer boss is called Alber. Bayer, a middle-aged German man with a red face, but he wore a tuxedo today, with a stiff collar standing high and a top hat on his head, making him look more than two meters tall, like a bear stepping on a wooden ball in a circus. Bayer's employees have learned to stick to the walls to enter the factory, and anyone can tell that the boss is waiting for an important guest, and it may be safer not to make a mess out of his sight.

Alber was waiting for Wu Chenxuan, but Alber, as a German businessman, was not interested in Wu Chenxuan's red top. The reason why he solemnly greeted him at the gate in advance was because of Wu Chenxuan's title of foreign academician of the French Academy of Sciences and the father of erythromycin, Albert, who is also a chemist and pharmacist, still admires this oriental counterpart very much, at least his own factory bought the authorization from the harsh British, and the erythromycin produced is always in short supply, if it is not for the aspirin and heroin in his hands, I am afraid that his main product now is erythromycin.

"Dear Mr. Sean, welcome to the Factory." Finally, an English carriage slowly stopped in front of Albert, and the eagle emblem on the body was the symbol of the Wuyi New Army, needless to say, this sassy Wu Daguan unloaded his carriage from the ship again, compared to the car that is still relatively naïve now, Wu Chenxuan's choice also attached to his identity, after all, he was still an earl of the Qing Dynasty.

After a while of greetings, Wu Chenxuan and Alber went to the living room of the factory, where a female secretary dressed in complicated medieval costumes brought coffee to Wu Chenxuan, and the female guard who followed brought the coffee and put it on the table. Wu Chenxuan smiled bitterly, classmate Du Niang is a 100% good guard, but he is not an excellent secretary, the German female secretary was originally going to hand it to Wu Chenxuan herself, but she intercepted it and did not hand it over, fortunately, the Germans thought that this was the rule of the Qing Dynasty and did not care.

The reason why he is so verbose is not because of Wu Daguan's score. He was secretly assassinated when he was about to leave the United States, but it didn't cause any shock, because someone poisoned his food, but he didn't escape the molecular structure scan, and the dish was replaced at the same time as the food was served to Lord Wu. It seems that there is no shortage of smart people in the world, and apparently some people guess that it is because of the positive performance in the anti-Chinese incident that a series of important figures against white supremacy organizations have been targeted and eliminated, which is exactly the revenge for Wu Chenxuan, but unfortunately they don't know how this is an unfair battle, like Don Quixote rushing at a full-powered Abrams tank with a spear. Wu Chenxuan did not rush to retaliate, but quietly left the United States, making the other party wonder if he had made a mistake in judgment, and when they ignored these Qing people with big pigtails, they would understand that the hidden arrow that was ready to attack was the most deadly danger.

Without further ado, at the kind invitation of Alber, Wu Chenxuan visited Bayer's factory and laboratory, although compared with the scale of his own standard pharmaceutical in Shandong, which has thousands of employees, the Bayer pharmaceutical factory with more than 400 employees still seems a little cramped, but the rigor and regularity of the German people are still reflected in various details. Looking at the near-complete medicines in the collection basket filled with scrap, just a little bubble when the mold was poured was judged to be scrap. Looking at the dusty floor in the production workshop, the white tablecloth without the slightest stain, and the workers who quickly packed the tablets with gloves, Wu Chenxuan was still very touched. It's not that the efficiency here is high or how the hygienic conditions meet the requirements of later generations of pharmaceutical production, in fact, these tablecloths and gloves are obviously cotton products, not disposable, probably not sterilized, and the excess of the microflora is almost inevitable, compared to the ultraviolet disinfection lamps and wormwood fumigation disinfection clothes and gloves in their own pharmaceutical factory, although they don't look very clean, but they are definitely better than the Germans in terms of flora standards. The disinfection in place was implemented under the compulsion of Wu Chenxuan, although there were iron-faced and selfless pharmaceutical factory pharmaceutical inspections from time to time, but the casualness of the Qing peasants and the cunning of the peasants made people very helpless. Fortunately, the Han nation's worship of knowledge is unparalleled, the workers who enter the factory are after a month of intensive knowledge learning and skill training, and in the content of the night school, interspersed with a lot of positive and negative teaching materials for abiding by the rules, of course, the authenticity is guaranteed, after all, from the well-paid factory, back to the poor countryside of the hired farmers are not one or two, every day at the factory gate standing waiting for the recruitment of the crowd so that these former self-cultivated farmers or hired farmers have a sense of crisis is always so strong, Although nothing can be fundamentally changed, those bad habits have finally converged.

Looking at this 19th-century factory with almost modern management, Wu Chenxuan feels that the difference between his Shandong industrial empire and the Germans lies in the difference between the craftsmanship and the habits of small farmers from ancient times to the present, and perhaps he needs to make more efforts in the basic education stage and social customs.

"Mr. Sean, what do you think of our factory's products? I think in the East we need a reliable trading partner to sell these drugs on our behalf. ”

"Uh, what?" Wu Chenxuan had to admit that he was distracted, but looking at the beautifully packaged products in Alber's hand, Wu Chenxuan immediately understood what the other party meant, "Of course, there are many pharmaceutical business companies in our Shandong Chamber of Commerce, and my own company also has sales channels in this area. ”

"Very good, and that's actually where our business wants to work with your standard company." Alber didn't know how to speak, and since Lord Wu brought it up himself, of course it was the best. "We're interested in your erythromycin and other macrolide products, such as roxithromycin, spiramycin, madisomycin, etc."

"I'm afraid I'm going to disappoint you, the authorization of macrolides in Europe and the United States has been given to the Birmingham Robin Pharmaceutical Factory in the United Kingdom." Looking at Alber, who couldn't hide the disappointed look on his face, Wu Chenxuan felt that there seemed to be nothing wrong with making the German businessman anxious. "But maybe we can collaborate in other areas, you know I'm a pharmacy professional, and we have a lot of researchers like me in our country, and we actually have new discoveries about antibiotics that are effective in treating streptococcal infections, maybe you'll be interested."

"Strep infection, are you sure it's a streptococcal infection? God, you say that your medicine is effective for sepsis. "Albert should not be left untouched, because sepsis is almost the mortal enemy of many old and infirm women and children, especially the alarming rate of maternal deaths from sepsis, if sepsis can be cured, then it is simply a gift from God.

"No, of course not all sepsis can be treated, but it is effective for some of them." Wu Chenxuan would never give him the impression that he could cure all diseases, in fact, the medicine he provided was just a very common antibacterial drug in later generations, who had ever seen that cotrimoxazole could cure all diseases?

More than 20 years later, German chemists would have synthesized a red dye called "Bailangduoxi", which was used sporadically to treat erysipelas and other diseases because it contained some antiseptic ingredients. However, in the experiment, it has no obvious bactericidal effect in the test tube, so it has not attracted the attention of the medical community.

But a German biochemist Gerhardt?? In the course of the experiment, Dumac found that "Bailang Duoxi" has a high efficacy on mice infected with hemolytic streptococcus. Later, he experimented with rabbits and dogs, both of which were successful. At this time, his daughter was dying of streptococcal septicaemia, and in his anxiety, he decided to use "Hundred Waves of Rest", and as a result, his daughter was saved.

Oddly enough, "Hundred Waves of Multi-Breath" kills streptococcus only in the body, not inside the test tube. Trefoier and his colleagues at the Institut Pasteur in Paris concluded that the "multi-wave" must have become something else in the body that was effective against bacteria. So they set out to analyze the active ingredients of "Bailang Duoxi" and decompose "amamsulfonamide". In fact, this compound was synthesized as early as 1908, but unfortunately its medical value was not discovered at that time. The name sulfonamide quickly spread widely in the medical community.

But none of this will happen, and of course the little girl's life will be saved, not as a clinical trial for her father, but on sulfadiadine tablets, a well-established antimicrobial drug from Bayer Medicine. Wu Chenxuan once again shamelessly plagiarized the achievements of others, although they did not know about it, and this time they intensified the sale of the invention that should have belonged to the Germans to a German company to produce, and a large amount of marks were exchanged for the materials and equipment that Wu Chenxuan needed, loaded onto the steamer, and shipped all the way east to Qingdao.

When Albert opened the drug experiment data and couldn't care about Wu Chenxuan, who was drinking coffee in front of the window, Wu Chenxuan smiled at the German sunshine and gently raised the coffee cup to celebrate his shamelessness and breakthrough