Although medicine can cure diseases and save people, the production of drugs is a process of chemical reaction, so the production process of drugs will produce a large amount of industrial wastewater, and these industrial wastewater also contain highly toxic substances, only a little bit can kill people.

At the same time, pharmaceutical factories can produce chemical weapons for murder after simple modifications, so as early as the mid-fifties, European and American countries legislated that pharmaceutical factories need to be kept away from human settlements, and at the same time, they strictly prohibit the direct discharge of industrial wastewater from pharmaceutical factories. Therefore, to build a pharmaceutical plant in Europe and the United States, it is necessary to build a wastewater treatment plant at the same time, and the industrial wastewater can be directly discharged after it has been treated to meet the specified discharge standards.

As the concept of environmental protection has become more and more popular in recent years, people's requirements for environmental protection are getting higher and higher, so European and American countries are getting higher and higher standards for industrial wastewater discharge from factories, and the implementation is becoming more and more stringent, so far the cost of wastewater treatment has accounted for 20% of the total cost of drugs, which makes the operation of many small and medium-sized pharmaceutical companies more and more difficult.

Maple Leaf Pharmaceutical Company is a typical example, due to the lack of sufficient competitiveness of the drugs produced, they can only rely on low prices to win, but the increase in labor costs and medical wastewater treatment costs, its profits are getting smaller and smaller, several partners saw that the pharmaceutical company has nothing to do, and has no intention of continuing to operate, so it was sold to Li Li for the overall price of 30 million US dollars.

In the 70s, the price in North America was not cheap, and the drug sales licenses in Europe, the United States, Australia, Japan, South Korea and other places accounted for half of the price. Ling Shizhe didn't know if it was appropriate to spend 30 million dollars, but Allison told him that the price was too high, and he could get it at most 26 million US dollars, which was still based on the fact that Maple Leaf Pharmaceutical Company was in good financial condition and had no foreign debt.

I can only tell Li Li to pay attention next time, and I must call professionals for things I don't understand, so as not to be fooled. Fortunately, although the price is a little higher, there are no sequelae, and you can rest assured that you can toss boldly. But through this incident, Ling Shizhe no longer dares to let Li Li be involved in the acquisition of the company, and leave it to professionals, she should continue to engage in charity, this is more suitable for you.

Maple Leaf Pharmaceutical's pharmaceutical factory is located more than 200 kilometers in the suburbs of Toronto, which is a seldom wasteland, and the land is full of hard rocks, which is not suitable for growing crops, so Maple Leaf bought this land and opened a factory.

North American enterprises are all a virtue, that is, large, not only the factory is large, but also covers a very large area, the land is vast and sparsely populated, so it is a small company, but the pharmaceutical factory of Maple Leaf is actually not small at all, Ling Shizhe calculated according to the weights and measures of the Republic, the entire pharmaceutical factory, including the sewage treatment plant behind, adds up to an area of about 150,000 acres.

With a small pharmaceutical factory occupying such a large territory, how big should the factories of those international pharmaceutical giants be? Ling Shizhe didn't dare to think about it anymore, he was already immune, anyway, North America gave him only one word, big. The car is big, the house is big, the garden is big, the farm is big, whatever you see is very big.

Because the product is not particularly popular, the plant is operating at less than 60 percent, and the factory produces eight drugs, six of which are over-the-counter anti-inflammatories, and the remaining one is an antibiotic for poultry and one is a hormonal solution for cattle.

Ling Shizhe wore clean work clothes, walking with everyone on the clean and bright workshop corridor, the factory's equipment is highly automated, and the number of employees in the entire factory is less than 50 people, so except for the sound of machine operation, there are few people in the production workshop.

After coming out of the production workshop, Yang Shuxin took everyone to see the warehouse, an automated warehouse with a modern atmosphere, with three-dimensional movable shelves up to more than 7 meters, and there were at least hundreds at a glance.

Two female warehouse managers in their 20s skillfully tapped the computer keyboard a few times, and several rows of shelves in the distance made room for the automatic access arm hanging on the steel beam, and several raw material barrels were accurately removed from the fourth layer of the shelves by the mechanical arm and placed on the handling forklift, and then the driver drove the forklift backwards out of the warehouse, and then turned around outside the warehouse, and finally drove the production raw materials to the production workshop.

Yang Shuxing happily introduced how advanced this warehouse management system is, but in the eyes of Ling Shizhe and Alison, this warehouse management system can only be regarded as general, not to mention anything else, the degree of automation of Ambrella's warehouse is much more advanced than the warehouse here, after the mechanical arm removes the goods, an unmanned guided vehicle will slide over below, and the unmanned guided vehicle will transport the goods or production raw materials to the designated location by itself, instead of driving a forklift to transport it as just now.

However, Ling Shizhe found something else in the warehouse: the goods were pasted with the special barcode of the warehouse, and the warehouse management scanned it, and the specifications and models, production dates, relevant parameters, storage time, purchasing department, price and inventory quantity of these drugs appeared on the computer monitor. If it is commonly used, the procurement specialist should be notified to stock up after taking it away; If they are not used frequently, the empty boxes and shelves will be reserved for other components that will be stocked.

This is the striped code warehouse intelligent management system being developed by Ambrera Systems Engineering Laboratory, which is a subsystem of the smart factory project, PLC, human-machine interface, inverter and servo motor, can be widely used in this warehouse.

This technology is not mature enough, and the expert team of the system engineering laboratory is still improving and perfecting it, so it is not for sale, but I didn't expect to see it here, it seems that after Li Li bought this pharmaceutical company, she took a lot of effort, otherwise she would not use the system that is still in the experimental stage here.

But that's fine, just treat this warehouse as a model project, advertise your company's products, and ask people to upgrade the warehouse of this factory and turn it into a fully automated intelligent warehouse. One more place to do data sampling can also bring the system to the market earlier.

After coming to the sewage treatment plant, Ling Shizhe smiled, because at a glance of this sewage treatment system, he knew that this was a product from Ambrera Company, judging from the cyan stain on the solar collector, this sewage treatment system was some years old, and the discarded sewage filter stacked there was also a product of Ambrera Company.

At this time, Alison walked up to Ling Shizhe and said: "Boss, this sewage treatment system is the first generation system produced by our company, and now Canada's requirements for environmental protection are becoming more and more stringent, this system can no longer meet the needs of the future, we need to upgrade it comprehensively." ”

"How much will it cost?"

Alison swept her eyes and said, "You don't have to replace everything, a lot of the basic hardware is off-the-shelf, you just need to replace some old-fashioned filtration systems, 2 million Canadian dollars is enough." ”

"Okay, by the way, I'll also do it in the warehouse, and I want to do it as a model." Ling Shizhe commanded.

"Okay, I see." Allison nodded, but looking at him as if he wanted to speak and stopped, Ling Shizhe asked, "What's the matter, if you have something to say, just say it." ”

"Boss, it can be seen that Madame cares about this pharmaceutical company very much, but to change the current predicament of this company, there must be new drugs. Boss, IMHO, developing a new drug is not an easy task. ”

Ling Shizhe pointed with his hand and said, "I can see that white-bearded old man, he is a Chinese medicine practitioner, and he has a lot of prescriptions for treating various diseases in his hands. ”

"You want to produce Chinese medicine? Oh! Buying cakes, boss, it's not a good idea," Alison was anxious, "You have to know that Western countries don't recognize your traditional Chinese medicine, thinking it's just witchcraft, sorry I didn't mean to insult your country, I just want to say that if you produce traditional Chinese medicine, you can't sell it, the Canadian government will not allow us to sell traditional Chinese medicine, and no one will buy those bitter, astringent and unpleasant black liquids." ”

"That was before, not anymore, and we have a new technology that can change that. Well, take a look. Ling Shizhe handed the list of Chinese medicine monomers to Alison, and then explained to him the idea of Chinese medicine monomer technology.

Alison took a look, and it read: Product NumberProduct NameEnglish NameTesting Purity

TCM-001 Bilobalidehplc≥99%

TCM-002 Ginkgolide AGINKGOLIDEAHPLC ≥98%

TCM-003 Ginkgolide BginkgolideBHPLC≥98%

TCM-004 Ginkgolide CGINKGOLIDECHPLC ≥98%

TCM-005 andrographolide andrographolidehplc≥99%

TCM-006 Dehydroandrographolide Dehydroandrographolidehplc ≥98%

TCM-007 Deoxyandrographolide Deoxyandrographolidehplc ≥98%

TCM-008 Neoandrographolide NeoandrographolideHPLC ≥98%

TCM-009 ChrysophanolHPLC≥99%

……………………………………

"This?" Allison looked at him quizzically.

Ling Shizhe explained: "Do you understand? These are all active ingredients extracted from herbs through biological extraction technology and can be used to treat diseases. With these ingredients, combined with those TCM formulas for drug synthesis, we can produce a variety of pharmaceutical products that meet Western pharmaceutical standards. ”

Since following Ling Shizhe, Alison has learned some of China's culture and history, and knows a little bit about traditional Chinese medicine, knowing that traditional Chinese medicine is sometimes very magical, but he always thinks that it is something that only primitive tribes have, a backward thing, and should be eliminated.

But now that he saw the table in his hand, and listened to Ling Shizhe's explanation, he completely understood what was going on, extracting the various active ingredients in the plant, and then synthesizing the active ingredients in these herbs according to the proportion of various herbs in the medical formula of traditional Chinese medicine, and then producing Western medicine tablets that Westerners can accept, which is the whole process of Westernization of traditional Chinese medicine.

Alison put down the list of Chinese medicine monomers in his hand, looked at Qin Junren in the distance, his eyes shone brightly, he already understood how important the Chinese medicine prescription in this old man's hand was, what was the most rare thing in the process of new drug research and development? It is the proportional synthesis of various compounds.

In many cases, pharmacists do not know which drug ingredients are needed to treat a disease, so they can only make a general deduction according to the basic characteristics of various chemical ingredients, and then do experiments on animals to collect data, adjust the drug formula little by little according to the animal's drug reaction, and then experiment and adjust. Generally, it takes about 15 years for a new drug to be developed to be clinically applied, and the annual cost is as high as 100 million US dollars.

When it comes to the clinical trial stage, it is not yet over, and it is necessary to continue to optimize the formula plan, and all kinds of side effects must be strictly recorded before they can be put on sale. The whole process is complex and lengthy.

Now with these traditional Chinese medicine formulas, you can skip all the previous processes, and directly make drugs for animal experiments, and only need to simply optimize and collect enough animal experimental data to apply for clinical trials with the health and pharmaceutical departments. In this way, the entire research and development process of new drugs is greatly shortened.

It's a huge preservation! Alison clenched her fists.

Understanding Ling Shizhe's intentions, Alison quickly took action, and after several rounds of negotiations, Qin Junren used the traditional Chinese medicine prescription in his hand as a technology share, accounting for 15% of the shares of Maple Leaf Pharmaceutical Company.

The company hired Qin Junren as the chief pharmacist of Maple Leaf Pharmaceutical Company to guide the company to westernize various traditional Chinese medicine prescriptions in his hands.

At the same time, Maple Leaf Pharmaceuticals changed its name to Ambrera Biopharmaceuticals Ltd., with an administrative status equal to that of other subsidiaries.

In addition, the Ambrera Pharmaceutical R&D Center was established in Raccoon Town to conduct research on drugs (mainly research on the Westernization of traditional Chinese medicine, and the factory with a lot of chaos was only responsible for the production of drugs. No database has been established by the medical research center.

Fourth......

Fifth......

After all these procedures were completed, Ling Shizhe also took out the viagra prescription in his hand as the first new drug after the establishment of the new company.

The main ingredient of Viagra is sildenafil, which is sold on the market, and has been listed on Viagra for more than ten years, bringing more than $2 billion in operating income to Pfizer every year.

Ling Shizhe remembers that in his previous life, the price of a viagra in China was 128 yuan, each box of 5 capsules was 495 yuan, and the price of 10 capsules was 965 yuan; The international price of 30 capsules per bottle is $240, which makes Pfizer profitable.

The emergence of Viagra brought a huge shock to the Republic at that time, they never knew that a drug that was just for the treatment of impotence/impotence could be sold so expensive, so domestic pharmaceutical companies began a crazy copycat, launching various copycat versions of Viagra, in order to grab the market of Pfizer, but unfortunately no matter how domestic companies copycat, people seem to only recognize Pfizer, for more than ten years, even if the patent protection period comes, Viagra is still the leader of the Chinese market, This cannot but admire Pfizer for doing a very good job in marketing.

Viagra is available at a dosage of 100 mg per capsule, and with the formula, Ambrera Biopharma quickly produced Viagra, a diamond-shaped, dark blue pill with the word "Viagra" on one side and the Ambrera "Umbrella" logo on the other.

The drug is made, but it cannot be directly marketed, and it must be tested on animals and collect enough data before it can apply for clinical application experiments, and finally it can really enter the market.

Ling Shizhe asked Yang Shuxin, even if there is a correct formula, it will take more than 3 years at the earliest, because the collection of various data is not missing at all, otherwise the government will not allow Viagra to be listed.

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