In Berlin in 1886, spring arrived at the end of February.

In the past February, in addition to remitting 200,000 marks in cash to Benz, John and Baron Cole also injected 300,000 marks into Heinz Medical Devices, planning to double the production capacity of all medical devices by May!

Although it was only two or three months into production, Heinz Medical Devices was a great success.

The whole set of surgical instruments has become a well-deserved money-making weapon, especially after the publicity and use of those doctors who have seen Charlotte Hospital, a large number of orders from European countries have come, and even North American businessmen have reacted, placing orders for 100 sets in February. Therefore, it is optimistically estimated that in the first half of this year, the surgical instruments designed by John are likely to sell thousands of sets!

That's a pretty impressive number for its price!

In addition, there is also a blood pressure monitor that also makes money, for this kind of thing that every physician should have, there is no pressure to sell tens of thousands of pieces a year, but the new thermometer and stethoscope designed by John, although the shape is small and exquisite, easy to use and fast, but because there is no revolutionary change, so the sales add up to the same as the blood pressure monitor, but the profit is much lower.

The sales of the products are booming, which brings about the lack of production capacity of the factory.

Baron Cole didn't care about the factory at first, and John didn't have any special requirements because he couldn't estimate the early sales, so the factory was small. The yield is not high. But in less than three months, everyone saw the huge potential of medical devices, and it was inevitable to expand the size of the factory. No qualified businessman will miss this opportunity. So as soon as the two families combined, they immediately injected 300,000 marks.

When negotiating the proportion of capital injection, the elder Huntelaar of course asked for the original proportion of shares, but Baron Cole wanted to contribute independently and increase his shareholding. After seeing the company's sales figures and future prospects, Baron Cole already regretted that he didn't overestimate it in the first place, but unfortunately the shrewd old Huntelaar was not a fool. What's more, John is not short of money at all now, and most of the money from the sale of shares in the bicycle company is still lying in his bank account......

The matter of the device company has been solved. Four new drugs from Heinz Pharmaceuticals have also been officially launched.

Aspirin, the drug of the century, along with three sulfonamides with their own characteristics, was officially put on the shelves of Heinz Pharmaceutical on March 1, becoming the first products of the pharmaceutical giant, which is expected to invest four million marks. The state-of-the-art and huge R&D building is still under intense construction. The expansion and renovation of the plant is still proceeding in an orderly manner. But under John's frequent urging and strict demands, Mr. Nicklaus still put great effort into ensuring the production of these four drugs.

Thousands of boxes of "samples" were sent to 300 physicians across Europe.

In the end, Mr. Nicklaus was not able to fulfill John's request, and only found the contact addresses of more than two hundred and twenty physicians, the vast majority of whom were Germans. If we take into account the movement of people and the change of address, it is expected that the number of physicians who can receive drug samples will not exceed 200. So on the day the new drug was launched, Nicklaus called John with some trepidation. It was a bit of a guilt, but the boss, Mr. Huntelaar, laughed. Didn't really care.

Demands are demands, and reality is reality, John knows very well in his heart.

And after reassuring Nicklaus, John immediately sent him a list of seventy physicians and their corresponding contact addresses. During this time he was not idle, writing to Bergmann and to Bilrot and Liszt, and even to the surgeons who attended the Berlin conference, and John was not much less efficient at finding people than Nicklaus.

Each of the nearly 300 physicians will receive five vials of aspirin and fifteen vials of sulfonamides.

Twenty vials of new medicine cost just over ten marks, and even three hundred physicians would only cost six thousand, and even with the shipping costs and all the expenses in the early stages, the cost would only be twenty thousand marks, a figure that once made the traveler grin for a night.

Compared with the cost of new drug research and development more than 100 years later, 20,000 marks is almost negligible.

In the 21st century, the names of pharmaceutical giants can be seen on the global R&D investment list all year round, and the top pharmaceutical companies have tens of billions of dollars in R&D investment a year, and the final R&D cost of a single drug is often as high as hundreds of millions, or even billions of dollars, but in 1886, John put four drugs on the market at the same time, even if you add the investment in factories and research institutes, it is only four million!

How could John not be happy with such a strong contrast?

In addition to the scary low cost of money, the time cost savings that made John even more happy.

From the time the four drugs were "invented" by John to the time they were put on the market, it was only three or four months, which is absolutely incredible if you put it in the 21st century.

In the future, after a new drug is born from the real room, it will still be a long time before it is on the market. It has to go through pharmacological research in the real room, animal real yàn, a small range of volunteer clinical trials, then a larger clinical trial, and finally a clinical trial of thousands of people......

Phase I clinical trial, Phase II clinical ......

Cumbersome processes often take years, but it's not uncommon if it takes more than a decade. Therefore, after a new drug is launched, it is often expensive for patients to afford, because in addition to the pursuit of high profits, pharmaceutical companies also have to spread the huge cost of R&D investment in the price of drugs. Only after the patent protection period has expired, and a large number of generic drugs have been put on the market, the price may slowly fall. And at that point, the brand name of the drug will play a key role......

But in this day and age, it's so simple.

If there is no concern that the effect of the drug will not be good after the market, which will affect the company's reputation, any pharmaceutical company can even launch a new product without any real thing. In fact, even decades later, there was still no requirement that they had to go through cumbersome practical requirements before they could be marketed, until an American company finally put the FDA, like a gassed daughter-in-law, into the hands of pharmaceutical companies in order to prepare sulfonamides with a toxic solvent......

"Gentlemen!"

In the conference room of the Heinz pharmaceutical company, the high-spirited John? Mr. Huntelaar exclaimed: "Although both Heinz Pharmaceuticals itself and our products have remained in obscurity so far, please believe that it will not be long before we will become the most famous pharmaceutical company in Europe and the world......

……

After struggling for a long time, I am ready to end the plot of Europe and return to New York. (To be continued......)