Charlotte Hospital, University of Berlin, Professor's Office of Internal Medicine.

When John walked into Mr. Wolfgang's office, the professor of internal medicine was scribbling down something. When he saw John, he immediately stood up and said excitedly, "Mr. Huntelaar, come and see this paper I have written!" ”

"Papers?"

John's brow furrowed, slightly surprised in his heart.

As a professor of internal medicine at the University of Berlin, it is normal for Mr. Wolfgang to write papers, in fact, he has published more than 100 papers so far, which can be regarded as a prolific researcher. But what makes John a little strange is why the other party wrote a paper that he wants to take a look at?

"Is it ......?"

There was a sudden movement in his heart, and John immediately leaned in.

Professor Wolfgang smiled as he handed the paper on the table to John, "This is a paper on the use of aspirin...... Well, I actually wrote two papers, one about its antipyretic and analgesic effects, which I have already written and am about to send out, and this one is about its treatment of rheumatoid arthritis, which is almost finished. Mr. Huntelaar, you are the creator of aspirin, and your knowledge of it should be above mine, see if there is any problem with the paper? ”

Really!

Professor Wolfgang had been experimenting with aspirin for almost two months, and the drug's efficacy was so clear that John would be surprised if he couldn't think of writing a paper.

Without hesitation, he took the paper, and John read it seriously.

Let's take a look at the finished one, that is, the antipyretic and analgesic effect of aspirin, which is also the paper that John values the most. The incidence of fever and pain is much higher than that of rheumatism, and the main sales target of aspirin in the later period is those people. Professor Wolfgang's dissertation contains a full hundred cases of fever and pain of various types. Roughly speaking, it was clearly about 70 percent, a figure that John was quite satisfied with.

Wolfgang's paper was written in a very regular manner, and John read it quietly, and then turned to the second paper.

The content of the second paper is also very simple, which is a summary of the results of aspirin use in 40 patients with rheumatoid arthritis. Although the conclusion is not yet written, the results of aspirin in the treatment of this disease are quite satisfactory based on the case reports alone. You must know that even after more than 100 years, this disease is difficult to cure, and countless patients have to endure the disease for many years.

The appearance of aspirin can at least link pain and inflammation.

"You wrote very well, I don't have any opinions!"

After a cursory look at the paper, John smiled and nodded.

As a professor of internal medicine, Wolfgang's ability to write papers is not necessarily above that of a traverser. But in this day and age, John is an absolute powerhouse, and John really can't find anything wrong.

"But ......"

After a simple agreement, John suddenly groaned.

Professor Wolfgang's brow furrowed, and he couldn't help but ask urgently, "But what?" ”

John's expression hesitated for a moment, and then he smiled and said, "Professor, I wonder if it would be more convincing if you used the control group?" ”

"Control group?"

Hearing John say this, Wolfgang was stunned.

"Yes. Professor. ”

Nodding, John continued, "Forty patients is certainly convincing enough. But I personally think that there is still a lack of patients who do not use drugs or other drugs as a reference, of course, the number of patients in the control group should be 40 to be comparable! We can even use mathematical methods to compare the two groups of patients without telling them about the effect of the drug in advance, and we can clearly see the advantages of aspirin......"

"Hmm......"

Wait until John's words are finished. Professor Wolfgang pondered for a moment and then nodded, "Yes, John, your idea is quite good, and it is indeed worth trying. ”

Randomized controlled trials are familiar to any physician in the 21st century. Even in Europe in 1886, the rudiments of this method of experimentation had been around for more than eighty years. But there are still very few physicians who use it. The reason is simple, most people don't care too much about the so-called results at all. But as far as John is concerned, he knows very well how much role randomized double-blind control real yàn will play in future drug development and clinical practice, so he can't help but remind Wolfgang at this time.

In every case, he wanted the efficacy of aspirin to be the most convincing.

Seeing Professor Wolfgang's thoughtful look, obviously interested in his own construction, John breathed a sigh of relief and opened the leather bag he was carrying.

Seeing John take out a bottle of pills, Professor Wolfgang's eyes lit up and he asked in surprise, "What ......is this?" Is this aspirin? Didn't Mr. Huntelaar, that Mr. Nicklaus say that aspirin will no longer be supplied to us free of charge? ”

"Uh......"

After hearing this, John's expression suddenly became a little embarrassed.

More than 300 bottles of aspirin were used in two months, which was not a lot for Charlotte Hospital, but don't forget, Heinz provided Wolfgang with all the medicines for free. But after two months of trial, Mr. Nicklaus also made it clear to Professor Wolfgang that it was no longer feasible to continue to give away, and that Heinz Pharmaceutical would supply Charlotte Hospital at a price of three marks per bottle, and at the same time build a hospital to resell to patients at a price of five marks per bottle!

God, Five Marks!

This price is not too expensive in the opinion of Professor Wolfgang, but too cheap!

A full fifty tablets of aspirin can meet a patient's ten-day supply, which is equivalent to only half a mark per day, Professor Wolfgang felt that Heinz Pharmaceutical was quite benevolent, and did not set the price arbitrarily because of its amazing efficacy, but gave a price that most people could accept.

John is also quite satisfied with this pricing.

Now is not the era when aspirin was worthless, as the latest "special drug", it is completely qualified to set a super high price. So when considering the price at the beginning, John did not hesitate to reject the retail price of two marks that Nicklaus finally offered, but directly increased to five marks!

Nicklaus didn't know the power of aspirin, could John not know?

In this era, a village woman's herbs in the United States dare to sell for a bottle for one dollar, and five marks is just a little more than a dollar, can aspirin be worth the price?

Are you kidding!

The reason why he dared to set such a high price was because John had strong confidence in the effect of aspirin, and understood that it would soon dominate the world of antipyretic analgesics and rheumatism drugs; Second, John firmly believes that even if other companies can find another way to synthesize it and eventually make acetylsalicylic acid, the cost will never be reduced to the level of half a mark a bottle. Because from the very beginning, what he "found" was the lowest cost production process that could be achieved with the technology of this era.

Developing a new drug, even just finding the production process for it, is an extremely difficult task for pharmaceutical companies in this era. Aspirin didn't appear until ten years later in history, and now that John asked him to "invent" it so much earlier, do other companies have the strength to do it? Or how long will it take, if they can do it? So in a short period of time, John was not afraid of a company that could imitate it.

And don't forget, Heinz Pharmaceutical's aspirin doesn't have a R&D cost.

John soaked in the real room for a few days, just to verify the preparation steps in his memory, and he didn't even need professional technicians to study it, and the ready-made production process was available......

But John came to Wolfgang today, not to change Nicklaus's decision to continue to provide free aspirin to the hospital. He smiled a little awkwardly, shook his head, and said, "Professor, these things are not aspirin!" ”

"What's not aspirin?"

With a frown, Wolfgang looked at the few bottles on the table, and his heart was really disappointed.

"Good stuff!"

With a mysterious smile, John put a bottle in front of Professor Wolfgang and said with a smile: "Professor Wolfgang, I dare to assure you that the things brought today will definitely not be worse than aspirin, in a sense, they are probably better medicines......" (To be continued......