It will be difficult for people in the future to understand what sulfonamides meant to the world in 1886.

Although in the 21st century, sulfonamides have gradually disappeared from the sight of many people because of various problems and the use of antibiotics and other drugs, but for people at the end of the 19th century, sulfonamides are undoubtedly super miracle drugs! Especially in this era, when the bacteria have not yet been affected by drugs, and the drug resistance is almost zero, the effect of sulfonamides is even more amazing!

So in general, John's words are not exaggerated.

However, Professor Wolfgang couldn't care about distinguishing the truth of John's words at this time, and he was now focused on the price and efficacy of these three sulfonamides, frowned and said: "In other words, the quantity of this bottle of sulfonamides is less than that of aspirin, but the price is as low as ten marks?" ”

There are only 20 capsules of sulfonamides in a bottle, but the price is more than 10 marks, which is indeed much higher than the price of 5 marks a bottle of aspirin, but there are 50 pills. You must know that the per capita income of Germans in this era is less than 1,000 marks, and this money has to support their wives and children, and the price of a bottle of 10 marks is really not cheap.

"Maybe fifteen marks, maybe twenty marks!"

Shrugging his shoulders, John added with a smile: "At present, it is only certain that it must be more than ten marks, but the exact price will not be known until the final cost is determined."

Of course, he understood Professor Wolfgang's concerns, but he certainly wouldn't set a low price because of this. Although these drugs have little to no R&D cost to speak of, John will not ignore this factor when pricing them, after all, he will not be able to "invent" all the drugs by himself in the future. On the other hand, the high price can also curb the "extravagance" of physicians and make them strictly follow the dosage recommended by Heinz Pharmaceutical. Thus reducing the harm to the patient!

It's not that John is worrying about nothing.

In true history, after aspirin was manufactured by Bayer, doctors used them as a panacea, and a patient could dose up to 25 tablets a day! In other words, they can knock out a bottle of aspirin in two days, and the doctors will even encourage them to eat more!

John had no interest in being a good man for all beings. But I also hope that my drug will not become a murderer.

Of course, Professor Wolfgang would not have thought of this, but his brow quickly relaxed after only a little confusion about the price that John had spoken. He didn't know how much it cost Heinz Pharmaceutical to develop and produce sulfonamides, but although the price of a dozen marks a bottle was very high, Wolfgang felt that it was still acceptable compared to its efficacy.

Of course, a qiē must be on the premise that they really work!

After thinking about it for a moment, Professor Wolfgang suddenly asked, "Mr. Huntelaar, what do you think about this kind of ...... Not. Are sulfonamides really confident? ”

"Of course!"

Shaking his eyebrows, John nodded as a matter of course.

"That's good!"

After taking a deep breath, Professor Wolfgang said in a deep voice: "There happened to be a thirteen-year-old girl in our ward, and the preliminary diagnosis was meningitis...... The girls are in a very bad situation, I'm afraid they won't last a few days, do you think we can try them now? ”

Just now, when John sighed about the range of adaptation of sulfadiazine, he once said that meningitis is one of them. Although Professor Wolfgang didn't know how he knew this, he now trusted John. So subconsciously found out the most critical case in the ward now!

"Now?"

The sudden request startled John's heart, but under the burning gaze of Professor Wolfgang. His expression quickly relaxed, and he nodded, "No problem, sir!" ”

If it is really meningitis, and the patient is very sick, it is indeed a great test for the first clinical application of sulfonamides. You know, even after more than a hundred years, meningitis is a very serious disease. The slightest carelessness on the part of physicians will lead to the death of patients, let alone in this day and age?

But......

Now is not the time to struggle with whether the patient's condition is too serious and whether the medicine can be effective, out of a doctor's professional responsibility, John does not allow himself to give up on treating patients in order to ensure the success of the medicine!

It's just that after a slight hesitation. John abruptly continued; "Professor Wolfgang, can I take a look at her medical records? Also, I would like to see the patient in person, and if possible, it would be better to re-examine it, is that okay?

"Check the medical records? Recheck? ”

Hearing this request, Professor Wolfgang's face sank, and his brow suddenly furrowed again.

A surgeon who has already been diagnosed with a patient wants to be re-examined? This is undoubtedly a kind of doubt for the professor of internal medicine, and it is also a provocation of Yan zhòng! Even if Professor Wolfgang is very optimistic about John, and the two have a pretty good relationship in private, this request is still difficult to accept......

"Don't get me wrong, Professor Wolfgang!"

Seeing the gloomy face of the professor of internal medicine, John also understood that he might have said the wrong thing, so he hurriedly waved his hand and said with a smile: "I don't mean to question your diagnosis, but ......"

"But what?"

Narrowing his eyes slightly, Professor Wolfgang asked in a cold voice.

Sighing secretly in his heart, John explained helplessly: "Professor, you should know that I published a paper a year ago about neuraxial puncture techniques, right?" “

"Huh? Well, I read that paper, and it's very interesting. ”

Slightly stunned at first, Wolfgang nodded immediately. Ever since he referred the first patient with acute appendicitis to surgery, Professor Wolfgang has been following all of John's research, and he must have read all the papers, but because he didn't know much about it, he had always used neuraxial puncture techniques on patients. Now that he suddenly heard John mention this technique, Wolfgang recalled the paper, in which John clearly explained the important role of cerebrospinal fluid extraction for meningitis!

Thinking of this, Professor Wolfgang's face suddenly softened a lot.

Taking advantage of the other party's improved face, John immediately continued: "Professor, I think you should also know that I have a real room in the surgical building, which is specially used for blood and bacteriological examinations, right?" “

"Of course I do!"

This time, Professor Wolfgang did not hesitate and immediately nodded.

The small yàn room, which John named as the laboratory department, can be said to be quite famous in Charlotte Hospital, because it is the first time that someone has set up a real yàn room in the hospital. And Professor Wolfgang also knows that whenever a patient who has undergone an appendectomy shows signs of infection, the laboratory will give them a bacterial culture, which sounds quite reasonable......

Smiling slightly, John went on to explain: "Personally, I think that a blood test and a bacterial culture for a patient with meningitis would be very good evidence for the diagnosis. If you don't mind, I guess this case can be tried......"

"Yes!"

After a moment of silence, Professor Wolfgang finally stood up and agreed to John's request.

If John was merely questioning his diagnosis, Professor Wolfgang would not be able to accept such an insult, no matter how good-tempered and close the two men were. But if the other party proposes a new examination method, using methods such as neuraxial puncture and hemogram examination that he has not yet understood, then his reaction will not be so intense.

Curiosity and thirst for knowledge are never lacking in professors of internal medicine.

However, as he was about to take John to the ward, Professor Wolfgang asked with some curiosity: "Mr. Huntelaar, it sounds like you have studied meningitis as well?" ”

"Uh...... Studied it for a while before, haha. ”

Yang Tian snorted a haha, and John replied vaguely.

As a surgeon, John did not have much contact with the disease meningitis in his previous life, but he had the relevant knowledge in his head, and he probably knew not much less than the internal medicine doctors of this era. Of course, he may not have as much experience in diagnosis as Professor Wolfgang, but don't forget, John's staff has the first laboratory in Europe, and he is also the inventor of neuraxial puncture, whether it is to do blood and cerebrospinal fluid examinations, or to do bacteriological practice, I am afraid that he is the only one in this world!

So no matter how you look at it, John has a lot of faith.

Wolfgang's eyes flickered for a few moments at John's answer, and then he nodded, "All right, Mr. Huntelaar, we can go to the ward now to see the young patient, but I hope you can understand that this sulfonamide is probably her last hope......"

"I understand, Professor!"

Taking a deep breath, John said in a deep voice with a stern expression.

Of course, he knew very well what Professor Wolfgang's so-called situation was strict, which meant that if he didn't intervene, the girl's fate would be almost doomed!

It's just that for him, on the one hand, out of a sense of responsibility as a doctor, he can't back down when he encounters this situation, and on the other hand, he also has a lot of confidence in sulfonamide drugs! Sulfadiazine is relatively easy to pass through the blood-brain barrier, and it is one of the preferred drugs for meningitis, and if the diagnosis is confirmed, the chance of saving people back is not low...... (To be continued......)