During the Age of Discovery, Western colonists brought terrible foreign diseases to Rice Island, which caused the deaths of millions of people in just a few years, and after the English began to formally immigrate to Australia in 1788, the aboriginal people also suffered from foreign diseases.

There is also an example of this in Fuso, where in the fifth year of Bunsei (1822), a typhoid epidemic broke out in Fuso, which was caused by sick sailors from outside Nagasaki.

Therefore, it is absolutely necessary to plan ahead for this.

With the support of Naohide, Oguri, Tanan, and others, and with the efforts of Ranyi Ito Genpu, Ogata Hongan, and Takano Nagahide, the first version of the epidemic prevention regulations in the fifth year of Kaei (1853) was completed, and it was continuously supplemented.

In a world where there was no Naohide, it was not until 1874 when Fuso and Zhuanzhai led the medical bureau that Fuso officially recognized Western medicine as the mainstream, and the following year it widely proclaimed the concept of modern "hygiene" to the public, and in 1874 began to develop modern medicine, and it was not until 1877 that the construction of modern drinking water channels began to be promoted, so that in the 20s of the 20th century, when the waterway system was basically complete, the cholera epidemic was basically eliminated.

However, although the epidemic prevention regulations came out, the dispute between Han Yi and Lan Yi made it not widely accepted, and in a few years, it was only implemented in a few places.

In June of the 5th year of Ansei (1858), cholera began to appear in Edo again due to the visit of Mi sailors.

Drinking water in Edo relies on two artificial waterways, Kanda Kamisui built in the 6th year of Kanei (1629 AD) and Tamagawa Kamisui that was added later.

Due to the conditions at the time, the waterways were not very safe and could be easily polluted. At this time, most of the poor townspeople lived in crowded places such as longhouses, and they did not have much concept of disease prevention.

To add insult to injury, the Chinese doctors, who accounted for a large share, did not fully approve of the treatment plan for cholera, and the number of doctors at this time was already insufficient, so Mr. Xuan Pu and others could only watch the large-scale spread of typhoid fever.

Fortunately, at the beginning of July, Mr. Genpo was cured of the emergency of the Gongfang family, and taking the opportunity of the family's desire to reward him, Mr. Genpo proposed to ask the shogunate to come forward to rectify the epidemic.

In fact, the shogunate took action after the outbreak of the epidemic, but it did not achieve good results for two reasons:

First of all, the method submitted by the Chinese medicine is unreliable, although it also requires the isolation of patients, but the overall efficacy is not good.

Second, it was not only a critical moment for the signing of trade agreements with Western countries, but also a critical juncture in political disputes, so it was natural that the top brass of the shogunate did not focus entirely on it.

However, this time, even Gong Fang contracted typhoid fever and almost died because of it, so the shogunate naturally became vigilant - if he didn't manage it vigorously, I am afraid that he and his family would not be spared.

Therefore, after being instructed by the public and personally interrogated by the head of the Daiji Isa, Mr. Genpo got his wish, and the anti-epidemic regulations he participated in were adopted by the shogunate, and many temples in Edo were requisitioned as special places to isolate the sick.

The main channels of transmission of cholera are water and food, and drinking hot water and hygiene alone can effectively prevent transmission.

Moreover, antidiarrheal powder, that is, berberine, is also a symptomatic medicine at this time.

After the shogunate allowed the future franchise and a few Miao characters with knives, the wealthy merchants and medical centers that originally made this medicine were also very interested, and immediately made the detailed preparation method public.

In mid-August of the fifth year of Ansei (1858), when Naohide left Edo to take up his post, cholera was already under control in Edo.

However, it is not known which shogunate leaked the news, and the fact that "the cholera epidemic came from the Mi sailors" became known to everyone at the end of July, and the government and the opposition formed a wave of condemnation of the culprit, so that the Mi sailors were attacked at the port of Shimoda in August of the Japanese calendar, and although no one was killed, many were injured.

Because the evidence about the sick sailors of the USS Mississippi was conclusive, the Mi envoy Harris could only protest verbally against the attack.

You know, this is not only the business of the Fuso people, but also the rice and British people in Uraga Port at that time, and many of them were affected.

Harris wanted to deny it, but the British envoy Ergin didn't do it - cholera is an imported epidemic, not the rice people, it is the pot of England and Lucia, who is this kind of rotten thing

Willing to contaminate.

Although justice was maintained in the matter of the epidemic, the rising cries of the people of Fusang still caused Erjin to be uneasy.

You must know that in the past two years, the most important event of England in the Far East, except for the Yarrow War, the anti-British activities of the people in Tianzhu have been a headache for a few days—as for the negotiations with Fuso, compared with the first two, they are not ranked at all in the Thames center.

At this time, the armed resistance of Tianzhu was in full swing, and at first it was only the upsurge of local public opinion against England.

Therefore, Ergin, who had learned from the past, attached great importance to public opinion, and he united with the special envoy of the Mi people, Harris, to put pressure on the shogunate, "The rights and wrongs of cholera, the Western countries will definitely maintain justice, but the resulting wave of unfavorable Westerners and trade, you must solve it!" ”

However, before the two sides could negotiate a solution, on July 22, 1858, the report of the Second Battle of the White Lord was transferred back to Edo.

The Lu people's fiasco again inspired the confidence of many people in Fusang, so the call for rebellion became even higher.

It just so happened that at this time, the Francis envoy Gloss also arrived at the port of Uraga - he came to Fuso nearly two months later than the British Ergin.

Although Britain and Buddhism joined forces in the Battle of Yarrow, the two fleets parted ways after the agreement between the Tsumen and the Tsumen was confirmed.

It turned out that similar to England's desire to go to Tianzhu to extinguish the fire, France also had its own pain - Annan was its only foundation in the Far East, and it was also unstable at this time.

England had been colonizing Tianzhu for many years and could be said to be deeply entrenched, but in contrast, Francis had limited power in Annam, and had previously been limited to trade and some privileges.

In 1856, the French Far East Fleet bombarded the port of Toulon on the grounds that "the Annam government illegally executed missionaries". But at that time, Francie had only one large, three and four warships in the Far East, so he could only vent his anger. This time, taking advantage of the Yarrow War, 13 warships reinforced the Far East, and naturally they wanted to intensify their efforts to seek "justice" from Annan.

Later, however, he heard that the four kingdoms of Mi, Lu, Britain, and Lan were negotiating trade with Fuso, and of course Gross refused to suffer, so he also went to Edo to take advantage.

In the previous battle of the Yarrow, Gross and the British envoy Erkifu sang with him, no, they cooperated very tacitly, so his opinion was very valued by Ergin.

After learning about Ergin's worries, Gloss came up with a solution, which is to lead to disaster!

"Aren't you worried that public opinion in Fusang is not conducive to trade, this is easy to do, and you can find an unlucky ghost to endure it. Suppression is better than channeling, and the two kingdoms of you and me have not made a big move in Fusang, and they can't suffer for others. ”

In fact, Gloss's original intention was to trap Rucia.

When it comes to foreign intrigue, Francis is a specialist. Compared with France, England, which is now known as the Europa-stirring stick, is actually just a rising star.

From the 15th century to the 17th century, during the Age of Discovery, the Habs ruled Spania as the leading nation of the time.

By colluding with the Ottomans, Francis desperately attacked the other two territories of the Habbs in Europa at that time, the Netherlands and Osmaga, and finally succeeded in pulling Spania from the throne of supreme power and taking its place.

To this day, the Francis are still very skilled in this regard, as evidenced by the Crimean War of 1853-1856.

The initiator of this war, which involved almost all the powerful countries of Europa, was none other than France!

Lucia certainly had reasons for moving westward, but it was the work of Francis that exacerbated the contradictions.

In September 1815, after defeating Napoleon, the Holy Alliance was concluded between Lucia, Osmaga and Prussia, and the spearhead was France. Therefore, the dispute over the Holy Land provoked by France in 1850 was an attempt to lure Lucia westward and provoke the contradictions between the foreign powers, and Francis was able to overcome the diplomatic dilemma.

As Francis had expected, the Holy Alliance broke down after the war, and the Anglo-Buddhist relationship reached its most intimate stage in history.

But during the Battle of Yarrow, Glos found a hint of bad luck - the two countries of Mi and Lu, who appeared as mediators, gained the English side

Admiration. The Mi people aside, but the cooperation between the Lu and the English in the Far East undoubtedly posed a danger to the present position of France.

The Kingdom of Prussia and the Osmaga were seeking a reunification of the Holy Roman Empire, which Francis could not tolerate - there were too many chess players in Europa, and it was not a good thing that there was an overly powerful country around them!

After Gorchakov became Minister of Foreign Affairs in 1856, Rusya worked to ease relations with his allies in the former Holy Alliance.

If the Holy League were to be revived, the only thing that France could count on was England, otherwise it would have to revert to the isolation it had before the Crimean War.

Whenever I thought about this, the Flemon Emperor Napoleon III shuddered.

Gloss agrees with the Emperor's insight, so he is prepared to spare no effort to wreak havoc between Yinglu and Yinglu.

In fact, the English envoy Ergin had awakened to his friend's thoughts, but the current situation made him inclined to Gloss's opinion.

After arriving in the Far East in 1857, the British envoy Ergin gradually developed several important views:

First, due to its geographical advantages, the Far East was the end of the empire's tentacles, so it was necessary to support local powers;

Second, for cultural reasons, the natives were very resistant to Europa indoctrination, and the empire itself was likely to lose more than it gained. Therefore, it is very advantageous to continue to support the original government - of course, first through whips and shackles to make these rotten bureaucrats "understand";

Thirdly, Lucia still cherishes the dream of a seafaring empire and refuses to honestly become an offshore nation. At this point, the Empire must dispel its delusions.

Thirdly, and finally, Elgin was heavily influenced by the bureaucracy in the English Far East.

These people reported to him in detail about the successive adventures of the Lu people in the Amur and alerted him to the collusion between Miru in the Far East.

In this regard, Ergin deeply agreed:

"After the fall of Alaska in 1856, the empire geographically divided Miru's territory. Therefore, restricting the ocean as an ultimatum would truly lead to a blockade of Lucia, and then it would naturally make it an ideal partner for the Empire - to be able to wave the flag in peacetime and shed blood for the Empire if necessary. ”

To tell the truth, the "reckless action" of the Lu envoy Ignatiev in Fusang deeply aroused Ergin's disgust.

Compared with the bowing down in China, Ignatiev's behavior now seems particularly annoying:

Not to mention the close relationship with the Mi people, the demand for the cession of the big island to Fusang highlights the burning ambition of the Lu people for navigation rights in the North Pacific!

However, Ergin also had scruples, so it was inconvenient to stop his military operations in the Northland.

You must know that Lucia borders China on land, and before the end of the Yarrow War, as an envoy to England, Ergin has always been worried about the Lu people directly supporting their opponents by land.

In the Crimean War, each side sent hundreds of thousands of people. In case the Lu people directly intervened in the Yarrow War, no matter how proud Elgin was of England, he would not dare to imagine that the empire was capable of sending so many people to the Far East!

Now, however, the Buddha's advice from Gloss has strengthened his faith:

"In any case, we should not let the immediate worries lead to the difficulties in the future.

If Rusia defeats Fuso, it will certainly make claims to the northern territories.

And this will inevitably lead to a resurgence of its ambitions for the Amur estuary. ”

Thinking of this, Erjin couldn't help but be a little afraid, fortunately the Lu people were defeated in the north, otherwise his suppression plan would probably not be realized after his victory.

In this way, under the influence of the Francis envoy Gloss, the attitude of the British envoy Ergin changed significantly, so at the end of August of the fifth year of Ansei (1858), the shogunate donated money to Britain and France in the name of purchasing ships, and then the envoys of the two countries agreed to mediate the war between Fuso and Lucia.

In fact, this is the intention of the British and the Buddha to let the tide of Fuso be directed towards Lucia, so this matter has opened a crack between the British and the Fosan Miru.

In the future, under the operation of people with hearts, this crack is getting bigger and bigger, and the future finally won a glimmer of life for Fusang.