It is now September of the 6th year of Ansei (1859), the second year that Naohide took over as Hakodate.

His appointment was a major reorganization of the northern land by the shogunate under the leadership of the head of the Daijii Iza department, which is really a big gesture to say.

In August of the fifth year of Ansei, the shogunate decreed:

The Hakodate White Lord was united, with the idle Hagimoto Yoshiki Naohide Hori as the new Hakodate Officer, the former Hakodate Hakunoshi as the Executive, and the Hakohara Hakodate Honori Hee Dai Guilty Meritorious Service, and the Hakodate as the new Hakodate Item.

As for the first class of the head and the group, they were declared by the two combined commissioners and appointed by Edo at his discretion.

Even the appointment of important military posts was basically delegated, which shows that the shogunate was ruthless this time, and made up its mind to have a good fight with Rusia in the Northland.

It can't be ruthless, and the huge pressure from inside and outside forced the shogunate to do this - Rucia's heavy defeats in the two battles of the White Lord caused too much shock to Fuso:

First of all, the suppressed Qi Zhao faction showed signs of a comeback.

Because of the two "great victories" to the outside world, the voices of the daimyos, shogunates, and the people rose again, so the shogunate received requests from various channels to revive the Qi Zhao line.

"The Lu people are insatiable, and they have repeatedly provoked wars, and the old people in Mito are not out of seclusion, so what is the life of Naifusang?"

Qi Zhao and others have been committed to reorganizing armaments and resisting foreign aggression, and have accumulated decades of prestige.

Moreover, what is even worse is that the agreement on the opening of trade has just been signed, and although the quality of trade will not be known until next year, the consequences of the large-scale invasion of Westerners have begun to be revealed - Westerners have brought not only military ships and goods, but also serious foreign diseases!

The diseases brought by the Westerners brought great trauma to Fusang, and at the same time, it also triggered a general wave of rebellion, which brought hope for the comeback of Qi Zhao's family.

In May 1858, cholera broke out along the coast of Fuso, and the cause can be traced back to the Mi people who visited Nagasaki.

The Mississippi steam-sail hybrid battleship has visited Fuso many times since the first visit of the black ship in the seventh year of Jiayong (1854). And its visit in May brought another profound disaster to Fuso.

The ship's departure point was Songjiang, China, and due to the Changfa Rebellion, the local displaced people gathered, and the people's livelihood was poor, resulting in a major epidemic - speaking of which, cholera is also a foreign disease to China, in fact, it itself originated from the Tianzhu Ganges River, and spread with the invasion of Westerners here.

Originally, the Nagasaki Prefecture had a quarantine system for Westerners under the leadership of Oguri Tadashun. But Fusang is weak, and this good program can't be implemented.

But no one knows whether it was because someone had contact with the crew of the Mississippi, or because the Rice people had blatantly violated the rules and went to the market to eat and drink, and anyway, the cholera outbreak finally broke out in Nagasaki.

Nagasaki was the second largest trading port after Osaka, Edo, and Kyoto, and the movement of people was extremely frequent, so the disease began to spread, and Kyushu, Kansai, and Osaka were not spared.

To make matters worse, the Mississippi came to support the Mi envoy Harris, and despite Nagasaki's obstruction of Oguri Tadashun's many obstructions, the ship continued to sail to the port of Shimoda Izu, thus bringing cholera to Kanto in June—one of the consequences of which was that Oguri would later be unusually tough on Westerners, especially anti-Rice.

In July, the same month that the shogunate signed a treaty with England, there was a cholera outbreak in Edo, and even Westerners were not spared—this was one of the reasons why the British and Mimetry fleets did not accompany them when the Lu people went north.

Of course, this also led the Lu people to bring cholera to the white master:

They only had one brief landing at Hakodate, and had no chance to spread the disease, but after the crushing defeat of the White Master, more than 400 people were captured, and cholera finally broke out while in captivity.

In a world where there is no Naoxiu to enter, this cholera has had very serious consequences:

In Edo alone, it is recorded that from July 27 to September 23 of that year, a staggering 280,000 Edo people disappeared from temples!

"The whole family died because of cholera, and there are countless heirs and stillbirths!"

Because of the large number of deaths, the number of coffins was not enough, and the wooden barrel became the final choice, and later, even the wooden barrel was too late to be made, so it could only be wrapped in a mat and buried, and even in the end, naked cremation became the result of helplessness.

But even so, the number of deaths far exceeded the limits of Edo's ability to cope, and Edo's temples and cemeteries were piled up everywhere

with decomposing remains.

Of course, there are different theories, and there is another statistic that believes that the real death toll should be 120,000.

But by all the odds, it's a staggering number!

Edo is boasted to have a population of one million, and the former is said to have lost more than 10% of the 100 people due to illness, and the latter is a disaster that Edo has never seen before.

This was related to the low level of medical care and the poor living environment at that time.

But now that Naoxiu has messed in, this situation has been greatly alleviated:

Cholera is known as "fever", "disease", "impersonation", "sunstroke", "arhat disease", etc., and is rumored to be related to foxes, wolves, and raccoon dogs.

Because of the rapid onset and rapid spread, this disease was a serious epidemic that everyone avoided at that time.

However, because Nagasaki followed Oguri Tadashun's letter, the root cause of the disease became widely known, and because it was brought by Westerners, cholera was later called "Oni no Cholera" in Fuso, which here refers to the contempt for Westerners as "Nanban Oni".

Cholera appeared in Edo in June, broke out in July, and was greatly alleviated by the time Naohide left Edo in August, and although more than a thousand people died, the situation was much lesser than the great crisis that could have occurred.

The epidemic in Edo was brought under control, and one of them contributed a great deal to the fact that although the shogunate attributed it to the Kokata Shogunate, "it is a blessing that the Kokata is wise and wise, and the elders, elders and middle shoguns are able to do so", but those who know know that this is actually the credit of the imperial physician Ito Genpo.

Mr. Hyun Pu was in the sixth year of Jiayong (1853).

At that time, Tokugawa Iekei, the 12th general of the Shogun, died suddenly due to illness, and then the chief Abe attendant of the old middle punished the Oku medical officer severely, and by the way, appointed the shogunate's first Lan doctor imperial doctor, that is, Ito Genpo.

This appointment not only saved the life of Abe's attendant himself, but also the life of the new public office, and now the entire city of Edo.

The rise of Lan medicine was after the introduction of Lan Xue by the eighth general Ji Zong (1684-1751). After that, the Han Yi and the Lan Yi began to fight endlessly, and in general, the Han Yi always had the upper hand - although, because the Lan Yi had a good way of curing the disease, the Han Yi side could not eradicate the opponent, but the suppression was not a problem.

Therefore, although he was appointed as an imperial doctor, there were many imperial doctors in Edo Castle, so Mr. Genpo was still the target of suppression.

However, Mr. Genpo was originally known as the "Three Great Orchid Doctors of Edo", and in recent years, he has become known for promoting pox in Edo.

Smallpox, measles, and chickenpox, known as the "Three Diseases of Life" during the Edo period, have always been considered the three terminal diseases.

But now, smallpox has also been basically cured, and Ito Genpo and Ogata Hongan have contributed a lot.

Ten years earlier, Ogata had been in Osaka and Bichu, and Ito had been in Edo and Hizen, and the two of them had worked together to promote the practice of inoculating pox, and finally it was publicly recognized by the shogunate in the third year of Ansei (1856), a point in time that would have been postponed to 1858 in a world without Naohide.

With good medical skills and a great reputation, coupled with the fact that the old middle Abe is taking care of him from time to time, Mr. Xuan Pu gradually gained a foothold in the imperial doctor.

Especially after the pox planting technique was officially recognized, the public sample family must have been very curious, and he also wanted to try it, and finally Mr. Xuan Pu's skillful hands succeeded in planting pox, which increased Mr. Xuan Pu's prestige in Edo Castle, but also made him cold again.

This is because there is still a certain risk in the pox method at this time.

The Chinese medicine among the imperial physicians used this to attack Ito, and no matter how Mr. Hyun Pu defended himself, he was "confident in his medical skills", but the reason of "ignoring the risks and flattering himself" was too strong, so in the end he was strictly forbidden to enter the inner castle of Edo.

If it hadn't been for the protection of Mr. Hyun Pu at that time, Mr. Xuan Pu might have been imprisoned.

It can be regarded as a good reward, and soon after, Abe Lai's wonderful hand was able to survive - in June of the fourth year of Ansei (1857), the victor Fang Lao Zhong Abe suddenly fell ill, and the group of doctors at that time was restrained, and it was Mr. Xuan Pu who rushed to hear the news to rejuvenate.

As a result, Abe's attendants escaped the fate of "being disheartened and refusing to heal themselves".

It's not a complete escape, at least the "discouragement" is true—the illness is cured, but in the name of "being too weak to serve as a director", Abe resigned from his position and quickly relinquished the position of the lord of the Fukuyama domain to his adopted son, the Orthodogus, and thus broke away from the shogunate that had exhausted him.

However, before Abe left, he asked the chief elder Hotta Masamu

book, washed away the grievances for Ito Xuanpu.

At this point, Mr. Genpo returned to Edo Castle and became the imperial physician of the public family.

It is difficult for powerful people to keep a low profile.

The famous Zhou Xingxing once said, "An outstanding man like you is like a firefly in the dark, spicy and distinct, spicy and outstanding."

In the following years, at the beginning of July of the fifth year of Anzheng (1858), Mr. Hyun Pu was outstanding again.

At that time, the official family was suddenly critically ill, which caused serious anxiety among the new "elders" of the shogunate, Ii Sao.

After personally inquiring into it, he found that there was a royal doctor's treatment plan that had not been taken seriously—Mr. Xuan Pu was usually ostracized by everyone, and the public who trusted him was often in a coma due to serious illness, so no one supported Mr. Xuan Pu's opinion.

Jing Yi still has the courage to sweep the head, and immediately promoted Mr. Xuan Pu to be the main director.

The prince was dying, and the imperial physicians, who were afraid of being convicted, no longer dared to reject dissidents, so the appointment was successfully approved.

In fact, the level of imperial doctors in Edo Castle is just like that:

Speaking of which, most of the imperial doctors are actually hereditary!

If this ancestor is a good doctor, will the descendants be good doctors? Even if you have a good background and good conditions, you can raise a hundred people with the same rice, even if you don't care about the difference in personal talent and hobbies, but hard work is always acquired, and the medical officer is hereditary, and it was taken for granted in the Edo period, and it is a big joke to put it on in the future generations.

Therefore, as soon as Mr. Xuan Pu, the real good doctor, made a move, Jiading's condition was stabilized!

Gongfang Xiangjiading's health has always been not very good, but this time his condition has worsened, and Mr. Hyun Pu believes that it is because of a new disease, and the interweaving of new and old diseases has caused it to be so serious.

This new disease was the cholera epidemic in Edo at this time.

After isolation, attention to diet and hydration, after taking the aspirin provided by Xianheng Foreign Company, Jiading's condition improved greatly.

This time, it was the "big elder" Jing Yi who was able to escape his fate - in Naoxiu's original world, there is a saying that the Gongfang family was scheduled to be in a coma at the beginning of July and died violently on the 6th, but the funeral was not until August 8. During this period, Jing Yi blocked the news, pretending that the family was not dead, and attacked political opponents.

After sobering up, Jia must be very happy, and is ready to reward the hero Ito Xuanpu.

Unexpectedly, Mr. Genpo didn't care about the reward, and directly explained the current cholera epidemic in Edo to the public office.

"But the quantity of this foreign medicine is limited, I'm afraid it can't save as many people, right?"

The idea of recovering from a serious illness is quite clear, but Mr. Xuan Pu really did not ask him to come up with medicine, but asked the public to solve the promotion of another medicine.

It turned out that after the outbreak of cholera in Nagasaki in the fifth month of the Japanese calendar, Oguri Tadashun, as a commissioner, wrote to Edo on a fast boat and asked for precautions.

At the same time, a large businessman Kinokuniya Toshihachi, who is a confidant of Oguri Tadashun, also finds Mr. Genpo and asks him for assistance.

Aspirin can treat cholera, but no one has ever said that other medicines can't do it, in fact, the antidiarrheal powder in Mr. Xuanpu's hand is also effective against cholera.

It was originally made by Naohide in his early days, but it was later transferred to major medical centers and several wealthy merchants in Edo, among whom Kinokuniya Toshihachi and Ito Genpo were the recipients.

This time, Riguri was entrusted by Oguri to unite with Mr. Hyun Pu to persuade the families to continue to vigorously produce antidiarrheal powder, and Oguri Tadashun also hinted at Chesturi that he hoped that these merchants and medical centers would disclose the manufacturing method of antidiarrheal powder.

However, cutting off people's wealth is like killing their parents, so despite being Nagasaki, Oguri, who has always been tough, still doesn't dare to be so domineering, but the situation is urgent, he still asks Feishu Lihachi, let Liba and Mr. Xuanpu think of a way together.

Although Rihachi was born as a servant of the Oguri family, and now he has to rely on his old master to shelter himself from the wind and rain, Rihachi's Kii Kuniya is now also an inseparable arm of the Oguri family - as a large grain merchant in Edo and even the eight countries of Kanto, a two-substitute merchant with branches all over the country, and an important member of the Edo Ten Groups of Tsuriya, Kii Kuniya also has the treatment of an important minister of the Oguri family.

Therefore, it was easy to make Kinokuniya public, but the subsequent rebound of the major wealthy merchants and merchants, Oguri Tadashun, who had been an official for many years, also had to consider for Rihachi, and he couldn't use the loyal dog to death at one time.

This is the disadvantage of not having a patent law, and now it is all about the exchange of interests, but how can there be so many benefits that can be exchanged!

To be honest, Liba feels that it is a great benevolence to supply antidiarrheal powder in large quantities at a low price!

Of course, he didn't know that Naohide had mentioned Oguri Tadashun many years ago, and the epidemic brought by Westerners was really terrible, and no matter how cautious he was, he couldn't treat it too much.