Since Anton Aiki expressed his subordination to the Asada, the Asada had no choice but to order Mori Keihiro to destroy the Barnyard family as soon as possible and assist the Takasuji Spo family in garrisoning Iwate County, and only after the arrival of reinforcements from the Chu-Tsu side could the attack continue.

At the same time, Tao Qingxian, Tamura Yoshiken, Soma Yoshiyin and other generals have led an army of 10,000 people to the eastern branch of Sangzuri Castle, Nakame Castle, Furukawa Castle, Miyazawa Castle and other famous castles to kill the important ministers of the Osaki family, Furukawa Tadataka (Furukawa Castle Lord), Yamori Dingnao (Shibuya Dingnao, Kuwaori Castle Lord, one of the four elders of the Osaki family), Nakame Tanba Mamoru (Osaki family deacon, Nakame Castle Lord, Shibuya Shuryu), Ishikawa Takachi (Iwasaki Takachi, Miyazawa Castle Lord) and others.

Osaki Yoshitaka caused the dissatisfaction of some important ministers because he favored beautiful retainers, small surnames, and side relatives such as Arai Takakei and Iwano Sohachiro, and gave them some power. After the death of the clan Yoshitsugu, Takaizumi Naoken (one of the Osaki family, the lord of Takaizumi Castle) had no choice but to let Araida Takakei, Iwano Sohachiro and others do the power and blessing, but he finally waited for the invasion of the Uesugi army. Before Tao Qingxian, Tamura Yoshiken, Soma Yoshiyin and others led their troops into Kami County, Takaizumi Naojian had already raised troops to defend the castle, and sent a messenger to inform Tao Qingxian that he had fallen to the Uesugi family, hoping that he could come to the rescue quickly.

Osaki Yoshitaka originally planned to order the retainers Nanjo Takanobu (a famous general among the Osaki family generals and the lord of Nakaxinta Castle), Satomi Takanari (one of the four elders of the Osaki family, the father of Araida Takakei, and the lord of Kamiwolf Tsuka Castle), Shigama Takahide (a relative of the Osaki family, the lord of Shigama Castle, and a military general with both wisdom and courage in the Osaki family) and others to lead an army of 3,000 to defeat the rebellious Takaizumi Naoken. However, when Yoshitaka Osaki learned that the Uesugi army had entered Kami County, he hurriedly withdrew his 3,000 troops and prepared to defend Meisheng Castle and Nakashinda Castle.

Not only that, but the lord of Masaka Castle, Takashi Ichisako, had long been dissatisfied with what Osaki Yoshitaka had done, so he took the opportunity of the attack of the Uesugi army to leave the broken ship of the Osaki family, and also raised troops to rebel in the castle in response to Takaizumi Naoken.

In the third year of Yonglu, on the seventh day of the first month. Due to the cage castle of Naoki Takaizumi and Takashi Ichisaki stubbornly defending and containing the retainers of the Osaki family in Kurihara County and Tamazo County, the reinforcements of the Osaki family were unable to go to Meisheng Castle for rescue, and Osaki Yoshitaka was completely isolated. As a result, Tao Qingxian first surrounded the famous castle of the Osaki family.

And Nanjo Takanshin would not be able to save Yoshitaka Osaki when he saw death, and immediately led an army of 1,000 out of the city with the intention of rescuing Mingsheng Castle. However, what Nanjo Takanobu did not expect was that Tao Qingxian had already prepared, and ordered Tao Longxin (Tao Qingxian's brother) and Tao Changfang to lead an army of 2,000 and carry 500 iron cannons to set up an ambush in the area of Miquan.

When Takanobu Nanjo was about to leave the Yonesen area with his army, he was hit by the fire of the Uesugi army, and Nanjo Takanobu was killed on the spot, and his 1,000 troops were defeated after a little resistance, and the Uesugi army killed more than 500 Osaki troops. Tao Longxin and Tao Changfang immediately took advantage of the situation to capture the important town of Zhongxintian City.

Because what Yoshitaka Osaki did on weekdays really made the retainers lose confidence in him, so when the Osaki family was in danger, the important ministers basically either fell to the Uesugi family or did not save them when they saw death, and watched from the wall. This also gave Tao Qingxian a lot of help and reduced a lot of his burden.

On January 9, after learning of the death of the heavy minister Nanjo Takanobu in battle and the reluctance of powerful retainers such as Yuyama Shushu (lord of Yuyama Castle), Takanbu Katsuoka (lord of Katsuoka Castle), Takashi Nagasaki (lord of Nagasaki Castle), and Maru Onoda (lord of Asahayama Castle) to lead an army to the rescue, Osaki Yoshitaka had no determination to continue to resist stubbornly, and soon sent his retainer Kurosawa Yoshitake (a member of the Osaki family, whose sister was the concubine of Osaki Yoshitaka) to negotiate with Tao Qingxian whether the Osaki family could continue to hold part of the territory and preserve the family name.

Tao Qingxian saw that Osaki Yoshitaka was no longer ready to resist, and told Kurosawa Yoshitake to let Osaki Yoshitaka open the castle and surrender to Kawagoe Castle to apologize. Tao Qingxian didn't want to spend too much time in Mingsheng Castle, because Kurihara County and Tamazo County had not yet been pacified, and only Takakumi Naoken and Takashi Ichisaki were still delaying the southward movement of the Osaki army.

Yoshitaka Osaki, believing that he was likely to be exiled to a remote area, ordered his retainers to defend him to the death, and he prepared to fight the Uesugi army to the death.

Tao Qingxian saw that Osaki Yoshitaka began to defend the castle again, so he ordered to place more than 500 heads outside Mingsheng Castle first, trying to deter the enemy from the momentum. As a result, when the defenders of Mingsheng City saw this, they were immediately frightened. Later, Tao Qingxian also took the opportunity to send troops to cut off the water source in Mingsheng City, and drinking water in the city became a big problem, and the Osaki army instantly fell into distress.

On January 10, Tao Qingxian ordered a general attack on Mingsheng City. Soon, Meisheng Castle did not resist for long before it was captured by the Uesugi army. After that, Tao Qingxian ordered the indomitable Osaki Yoshitaka and his retainers Satomi Takanari, Shigama Takahide, Kurosawa Yoshitake, Araida Takakei, Iniwa Nogami Aki, Iwano Sohachiro, Kitago Mitsukiyo, Yoneizumi Nagayuki (Yonesen Pavilion Owner) and other more than 1,000 people to be slaughtered.

With the capture of Meisheng Castle by the Uesugi army and the killing of the Osaki family's governor Osaki Yoshitaka, the lords of the Osaki family who had not yet fallen to Kurihara County, Toda County, Shida County, Tamazuku County, Kami County and other places did not fall to the Uesugi family, and they were also defeated by Osaki Yoshitaka and were successively destroyed by Tao Qingxian's army. After defeating the powerful retainers of the former Osaki family, such as the Ichuri family, the Yagisawa family, the Miyazaki family, the Tani Mori family, the Kasawara family, and the Ishikawa family, the Uesugi family completely controlled the five Osaki counties (Kurihara-gun, Toda-gun, Shida-gun, Tamazo-gun, and Kami-gun). Because of the heavy snowfall, Tao Qingxian was unable to rescue Maori Jingguang after defeating the Osaki family, so he could only send people to transport grain and grass by sea to Waga County.

At the same time, Maori Jingguang, who was still worried about Nanbu Qingzheng leading his army south, instantly relaxed. Because at this moment, Anton Aiji led his army to launch an invasion of Antlers, intending to attack Hokurichi.

At the beginning of the first month of the third year of Yongroku, Anton Aiji led an army to attack the Tsutsu Shenjing Castle in Antler County, but the southern family did not anticipate the surprise attack of the Hiyama Andong family, and the southern army declared the city broken after holding on for two or three days. Perhaps because the initial battle was too smooth, Anton Aiji attacked in two ways without making preparations, and successively attacked the two places of Jiancheng Changniu Castle and Ishitori Valley Castle occupied by the Zhibu family in Rutsu Zecheng, Suehiro Castle, Kurosawa Castle and other places.

However, after all, Anton Aiji is facing the southern family, which is famous for its quick action and good fighting. After learning of the battle situation on the front line of Antler-gun, Harumasa Nanbo, who was in Kita-Iwate Prefecture, sent troops to support him quickly, and on the other hand, he gave a death order to the retainers and countrymen lords stationed in various parts of Kashima County to hold the castle. The morale of the Southern Army, which had been cornered, was unprecedentedly high, and the Anton Army's plan to take Antler County with a surprise attack was put on hold. Anton Aiji, who was sitting in Tushenjing City, saw that the two sides were stuck in the quagmire of an imminent war of attrition, and began to get anxious, after all, the Hiyama Anton family could not withstand such a consumption of the southern family. After weighing the pros and cons, Anton Aiji made the decision to retreat to Doshenjing Castle to secure the bridgehead in Antler County. Since then, the war between the Hiyama Andong family and the southern family has formed a tug-of-war, and everyone has their own winners and losers.

Later, heavy snow fell again in the north, and Harimasa in the south also rushed to Antler County with 5,000 troops, and the Andong army, which could not even save the castle in the valley, reluctantly withdrew from Antler County after a fierce battle. The southern side did not make it appear that they wanted to pursue Anton Aiji, and after consolidating the border defense, they retreated. At this point, the first antler invasion battle ended with the Hiyama Andong family winning first and then losing.

And Nanbu Harumasa had to lead his army south to Iwate Prefecture again, because he didn't want the Uesugi family to completely occupy Iwate County. Once Iwate Prefecture is completely controlled by the Uesugi family, then the southern family will lose the buffer area, and the Uesugi domain will completely border the Kunohe County of the southern territory, and once the Uesugi army goes north to invade the southern family, then the southern family will have to be forced to fight in the territory, which is what Nanbu Harumasa does not want to see.