Chapter 897: Human Pharmacological Experiments
Yang Yuanzhao, who got the news, had already gone to bed, and after getting the news, he got up as soon as possible, the importance of penicillin, he knew very well that although sulfonamide was the first broad-spectrum antibacterial drug, he had too many side effects, the scope of treatment was relatively small, and the effect was not good. There was no choice before, but in the meager historical knowledge, a suitable antibiotic was found, and if there was another choice, penicillin would definitely replace sulfonamides.
As the opener of this topic, in four years, he almost single-handedly promoted the research of penicillin, and even invested more than 20 million US dollars per year in this project, accumulating 100 million US dollars in 4 years, and received a lot of criticism, but when the development of penicillin broke through the original predicament, and initially purified and crystallized to the extent of human use, he still couldn't suppress his excitement and came directly to the First Institute of Biology in Northwest China.
As the most important biological laboratory in the northwest, the research of antibiotics and even sulfonamide preparations, the security level of the first laboratory is quite high, and there is at least triple protection around the entire research institute, and even in the interior of the research institute, there is also the protection of 1 battalion of regular internal security troops all year round, and it is in the core of the northwest, and the protection is the most tight, so it can be said that the protection is extremely tight.
Yang Yuanzhao's arrival alarmed many people. The current northwest is no longer the original, only Baotou is a small place that has not yet radiated out of Inner Mongolia. Now the northwest is already the center of the whole of China, one of the great powers recognized as a powerful country, the existence of Yang Yuanzhao, as for the northwest, it is a giant and the existence of the Dinghai god.
Any movement of him has been followed by people, and there are even many big names. Because of Yang Yuanzhao's sudden visit, he became interested in the First Institute of Biology. But after carefully understanding everything about the First Institute of Biology, especially after the investment of hundreds of millions of dollars in 4 years. And another important project of this First Institute of Biology is the in-depth study of drugs such as sulfonamides, and after knowing this, all the big people who are qualified to pay attention to Yang Yuanzhao are qualified. Almost all of them retracted in unison. Sulfonamides and polymers, these two major fields, in the past three years, or even more time, can be called the pillars of the entire Northwest, it is the emergence of these two commodities, like the leader, split the pace of Northwest sales in the world.
Sulfanilamide. For many incurable diseases, it is a life-saving medicine. For women in the West, stockings are an indescribable temptation, and in the case that others cannot produce them, these two commodities have become irreplaceable and inevitable choices, even if their producer is a country that has never heard of it, it must be sought after.
Because of this, the Northwest through bundle sales and some other means, with these two products as the guide, easily tore open the market of other countries, into or not into this is an initial level, after successfully passing this initial pass, everything is logical, China's huge population resources, Yang Yuanzhao brought, based on the concept of later generations of assembly lines and advanced production machines, all make the products of the Northwest cheap, very competitive, in this case, to create the Northwest products popular all over the world.
The same research institute as sulfonamide research, with a cumulative investment of 100 million US dollars, these two points are like two huge weights, hanging high, everyone knows that Yang Yuanzhao's attention to him is absolutely unprecedented, as long as this drug has half the power of sulfonamides before, whether it is investment, or Yang Yuanzhao's attention, these are not something that any of them can peep into.
The news of Yang Yuanzhao's arrival soon spread in the First Institute of Biology, Song Wan, the head of the First Institute of Biology, and Zheng Yu, the person in charge of penicillin research, both came to the door to greet them, even if it was a good opportunity, Yang Yuanzhao was also very concerned about penicillin, not only ordered the secretaries to observe the progress of penicillin at any time, but he himself, in the past 4 years, also came to the institute 6 times to inspect, whether it was Song Wan or Zheng Yu, they all knew him.
In the past 6 years, the northwest has developed too fast, in just 6 years, from a poor country with no industrial base, to a country with multiple categories and different types of industries, and the researchers who have emerged with the development of the northwest have gradually become domestic researchers from the very beginning of foreign researchers, and a small number of Chinese themselves have a sufficient foundation, and in the high-intensity research, they have gradually mastered scientific research methods, and the two are combined. The result was a group of China's most outstanding young scientists.
If there are enough researchers in the northwest, Yang Yuanzhao can develop most of the projects in the northwest in the future, but unfortunately, up to now, there are still about half of the research institutes under the leadership of foreign countries, and some projects of far-reaching significance to the country and the system, as well as some forward-looking projects, cannot be continued at all.
A brief greeting to the two people, by the way, asked about the process of penicillin purification, at any time, money and people are ready-made, these two things, for projects with definite goals, always have a huge effect. The initial research was carried out very slowly on the purification and isolation of strains, and then the speed was accelerated after some understanding of penicillin. After a series of failures, the Northwest was divided into hundreds of research groups, starting from the import of melons from all over the world, and made a breakthrough, in a kind of melon, found the possibility of large-scale extraction of penicillin, and the production of penicillin began to increase tremendously, from the original laboratory production, into small batch production. And this time, it has progressed from melon to corn solution, and in the specific corn solution, not only the concentration has reached the standard, but the yield has also increased significantly.
Now, the unit of penicillin has progressed from ten to thousand, and gradually moved closer to 10,000, the pharmacology and animal experiments on penicillin have been carried out almost, and it is fundamentally affirmed that penicillin has a broad-spectrum antibacterial ability for a large number of bacteria, and has no effect on the human body, because the role of penicillin refers to the molecule containing penicillane, which can destroy the cell wall of bacteria and play a bactericidal role in the reproduction period of bacterial cells, while there is no cell wall in human and animal cells. So it doesn't matter.
Looking at the excited Song Wan and Zheng Yu, Yang Yuanzhao was as happy as them, and the wings of a butterfly were born at least 30 years in advance, and the birth was enough to have an effect on the human body and kill most of the germs of this era.
"What is the yield and purity?"
"Now all the laboratories of the First Biological Laboratory can produce about 120,000 copies of 1,000 units of penicillin per day according to the existing method!"
Yang Yuanzhao nodded, he knew that the first biological laboratory was huge, with more than 200 different laboratories, penicillin in a certain sense, as long as the preliminary research was completed, it was not a special thing to produce him, otherwise there would not be so many million units in the future, or even tens of millions of units, and the price was so cheap, nodded and said: "Complete the conversion from laboratory to factory production as soon as possible, and put it into production as soon as possible!" ”
"But!" Zheng Yu looked at Yang Yuanzhao with some hesitation, I don't know whether to say it or not, penicillin has completed all the preparations, and the effect of thousands of units of penicillin on the human body is definitely strong enough, but they have only done animal experiments before, not physical tests, with Baotou's attention to human rights issues, they rashly entered the medical system, which was a disaster.
After hesitating again and again, Zheng Yu still mentioned his opinion, Yang Yuanzhao listened to it for a while, stunned for a moment, he knew very well what the side effects of penicillin were, and also mentioned it, for penicillin, you need to do a skin test, there will be certain adverse reactions, and there will be no others, but the following researchers don't know, with the Northwest paying more and more attention to the rights of ordinary people, it is impossible to target the people on a large scale.
From the beginning of the production of sulfonamides in the northwest, the research on sulfonamides has not stopped, from the very beginning, most of the sulfonamides are synthesized by Yang Yuanzhao, and later, the northwest produces and purifies by itself, with the role of various advanced machines, the cost of sulfonamides is quite low, in this case, it is not difficult to provide the prisoners of war, it was not possible to reach the height of Yang Yuanzhao, but after the biological research institute knew, I felt that this was an opportunity, and the prisoners of war were introduced from Germany. The original purpose was not to solve the problem of labor in the more dangerous areas of the northwest, but now that they are sick and need medicine, in the spirit of humanitarianism, then give them the latest special medicine.
This statement is a little shameless, but Yang Yuanzhao, who came from later generations, knows very well that there are also foreign drug giants in later generations, and large-scale drug experiments in China and some other underdeveloped regions using money as an inducement are just not reported. In the dark jungle era of the early twentieth century, the target was prisoners of war who did not have many rights, and it was natural that penicillin entered the drug system of prisoners of war in the name of new special drugs. (To be continued......)