Two months later.

Chen Chen stood quietly in the laboratory, his face a little pale.

In front of him, a guinea pig swam in a maze of morris water.

The mouse is an extremely nimble swimmer, and although it looks a little lost, it always finds the right way quickly after the wrong attempt, and finally finds the platform hidden underwater.

No one could tell that the mice had shown signs of severe nerve damage two weeks earlier.

Watching the No. 5 experimental mouse come to the platform, Chen Chen gently pressed the timer and said expressionlessly, "28 seconds, 2 seconds faster than yesterday." ”

Subsequently, Chen Chen began to fill in the experimental records:

"Six-month-old genetically modified model mice were treated with surgically transplanted clonal neural stem cells, treated with the myeloid trigger receptor 2 (trem2) agonist interleukin 4 (IL-4) and induced microglia activation."

"Immunohistochemistry, immunowestern blotting, and fluorescence quantitative PCR were used to detect the expression of trem2 at the protein and gene levels."

"The water maze experiment showed that the model mice showed cognitive recovery in the water maze experiment."

"In this model, IL-4 treatment increased the expression of trem2, and the memory and cognitive impairment of the model mice was greatly improved."

"Results: Activation of trem2 may promote decreased autophagy in microglia through an inflammatory response."

Then Chen Chen bent down, caught the mouse that was resting on the platform, dried it and fixed it on the CT machine, and fixed the brain to a state where it could not be rotated.

Then, Chen Chen started the machine, and the CT machine began to scan the brain structure of No. 5.

Comparing the new CT with the previous image, I saw that the brain structure of the mouse was much fuller than last week, and it was a huge change from two weeks ago.

If two weeks ago the brain of a mouse was like a shriveled walnut, now it is much fuller, like a swollen dough.

Casually sorting these data into the corresponding categories, Chen Chen looked at the few mice with the same performance left in the experimental cage, and casually covered the experimental cage.

Then, Chen Chen turned around and held the head of the No. 5 mouse, while pinching the tail root of the mouse with his right hand and pulling it gently.

Click!

There was a crisp click, and No. 5 in his hand died in a rapid and effective cervical dislocation.

Chen Chen placed the mouse on the dissecting table and began to dissect its brain.

Ten minutes later, No. 5's brain was completely separated, but it was not until this time that Chen Chen found that the brain of this mouse had not recovered well.

Because of the death of a large number of neurons produced by Alzheimer's, the areas where these nerve cells die produce many connective tissue blocks, which occupy the original space of the brain, making it impossible for the brain to return to its previous state.

"It's a pity."

Chen Chen shook his head and soaked these brains into a solution filled with formalin.

In the past three months, Chen Chen has used cloning to clone the mice, and at the same time, in these mouse models that also have Alzheimer's disease, a compound treatment method has been adopted.

1. Use the gene overexpression of TOM1 protein to improve the brain's resistance to inflammation and gradually eliminate inflammation.

2. Use the solanezumab antibody developed by Eli Lilly to remove Aβ protein and amyloid deposition in the brain.

Although the drug has failed several clinical trials and has been shown to be unable to treat Alzheimer's disease, its ability to clear the Aβ protein is still worth affirming.

3. By injecting neural stem cells extracted from cloned embryos, and using cytokines to activate the original G2 quiescent stem cells in the brain, stimulate brain self-healing.

Finally, in the early stages of Alzheimer's disease, microglia are activated to actively engulf abnormal deposited proteins.

However, if Alzheimer's disease has reached the middle or even late stages, microglial activation is inhibited in the opposite way until most of the Aβ deposits are removed with a solanezumab antibody.

This is the method taken by Chen Chen, through the treatment of inflammation, as well as neural stem cell transplantation, coupled with the intervention of the immune system of the brain itself, this composite approach can completely suppress Alzheimer's disease in the early and middle stages, so that it cannot worsen, and even produce improvement.

In fact, the real medical community is not unable to achieve Chen Chen's effect, the only limitation is still cloning, in addition to this limitation, cost is also a factor restricting this treatment.

After all, the cost of this treatment plan alone is sky-high, and if it is applied to the commercial, a course of treatment will cost millions of dollars.

As for the steric hindrance effect caused by the death of a large number of neurons, and the occupancy of connective tissue in the brain, Chen Chen is helpless, and perhaps it is a good way to remove these connective tissues through craniotomy.

As for the NZT-48, due to lack of time and no actual progress, Chen Chen stopped the experiment.

Since the NZT-48 experiment was stopped, Chen Chen also began to beckon his assistant to assign some less important work, which was why he got the results of these experiments so quickly.

Now that the experiment has achieved results, Chen Chen no longer hesitated, and directly asked his assistant to send in the elderly chimpanzees that had been prepared before.

The scientific community has long discovered that chimpanzees can get the same Alzheimer's disease as humans, so before the mouse experiment was completed, they asked their assistants to make models of Alzheimer's disease of chimpanzees and clone them.

This also saves a lot of time.

Not only that, Chen Chen also asked the team to protect his parents in Zhongzhou District to secretly extract Professor Wang Xi's somatic cells and bring them back to clone Professor Wang Xi, and when Professor Wang Xi really came to the research center a few months later, he could immediately use the cloned neural stem cells.

Such hard work can be regarded as a kind of reward for Professor Wang Xi.

Thinking of this, Chen Chen was just about to carry out the next experiment, when suddenly the phone rang.

Chen Chen frowned, picked up his phone and looked at it, only to find that it was a call from the screenwriter in charge of the new movie.

Leaving the laboratory to his assistant, Chen Chen walked out of the laboratory and connected the phone.

"Modified? I see, I'll check it out later. ”

It turned out that the screenwriter had revised the script again according to Chen Chen's requirements and brought it to Chen Chen for review.

This is the task entrusted by Chen Chen to the Edwards family.

When he came to his office, he didn't need to be instructed, Xiao X had already opened his mailbox and projected the script sent by the other party on the wall.

Chen Chen took a few minutes to read the entire script, and then nodded reluctantly.

The story background of the script is set 3 years after reality, this is what Chen Chen requested, after all, the USB flash drive only accepts movies that are close to the real structure, and it is safer to set it directly to the realistic background.

The main line of the story is that a researcher named Alexander, a little-known pharmaceutical company in North America, suddenly discovered a small chemical molecule that can completely inhibit Alzheimer's disease.

This small molecule can not only stop tau nerve tangles and stop Aβ deposition, but also eliminate inflammation and completely end all symptoms of Alzheimer's disease.

This drug is the heart of the story.

And the plot is an unknown underworld force who got the news out of nowhere, and in order to get a drug sample, he began to kidnap his colleagues around the protagonist, and the protagonist quickly escaped with the drug after discovering the situation, and was chased and killed all the time.

This script has been passed by Chen Chen several times before, and in desperation, the screenwriter removed some parts of the movie that are not logical in technology and logic, although these parts are very dramatic and very selling.

But this time, it was almost in line with Chen Chen's expectations.

It's a pity that Chen Chen didn't expect Hollywood to be so slow, it took two months from script writing to revision, and no matter how fast the movie was left in one month, it was impossible to rush the movie out.

Fortunately, Chen Chen has found a treatment to inhibit Alzheimer's disease, and as long as it can be successful in chimpanzees, Chen Chen can enter clinical trials.

Thinking of this, Chen Chen, as an investor, replied to the other party with a "pass".

In this way, the movies on the Hollywood side can be officially launched.