Gao Fei, who was sampling the environment in the living room, opened one of the cabinet drawers, was suddenly stunned, and only reacted two seconds later, and shouted at Zhou Jie in the kitchen, "Old Zhou, come and see!" What is it? ”

Zhou Jie came out of the kitchen when he heard the sound and walked to Gao Fei, and Wang Peng's wife also followed.

Gao Fei pointed to the drawer that had just been opened, and saw that the cabinet drawer was full of dazzling medicines, neatly arranged.

There are many types of medicines, but most of them are antibiotics, which is more complete than some pharmacies.

Gao Fei exclaimed: "Your family used to open a pharmacy? So much medicine! ”

Wang Peng's wife explained: "No, these are all bought by my husband from the pharmacy, and he has saved so much one after another, and the box is empty." ”

Zhou Jie frowned slightly, and asked, "These medicines are all taken by you yourself?" ”

"Yes, it's basically my husband's food."

"What's wrong with your husband? Why take so many antibiotics? And there are so many types, it shouldn't be prescribed by a doctor, right? ”

"My husband has a habit of cleanliness, and every time he comes back from eating out, he will take a tablet of antibiotics, and sometimes he feels that his own food is a little raw, and he will also eat a tablet, and he has accumulated so many boxes over the years."

After listening to Wang Peng's wife's explanation, Zhou Jie and Gao Fei looked at each other.

I've seen people who are clean, but I've never seen such an exaggerated and ignorant cleanliness.

Zhou Jie picked up his mobile phone and took a picture of the cupboard, and asked Wang Peng's wife on the side: "Except for your husband, do other people in your family often take these antibiotics?" ”

"My husband sometimes gives food to his son and her mother, but I rarely eat it."

Zhou Jie felt speechless, but finally instructed Wang Peng's wife: "Antibiotics must be taken according to the doctor's instructions, and you can't eat them casually, otherwise you will die." ”

——

Lianhai Center for Disease Control and Prevention, Emergency Office.

Just as Gu Yanan was frowning, thinking about which pathogen should be tested next, the hospital sent samples of Wang Peng's son Wang Fei and Wang Peng's mother.

Wang Peng's mother and son were suspected of being infected by Wang Peng because they had fever, so they were also admitted to the hospital by Gu Jiashu.

Lu Li and Wang Xiaoxiao also brought back, Wang Peng's colleagues and specimens from the restaurant where they had dinner last night.

At the same time, Zhou Jie and Gao Fei returned from Wang Peng's house, and after sending the food samples and environmental samples in Wang Peng's refrigerator to the laboratory, the two returned to the emergency office and talked about their experience at Wang Peng's house.

Gao Fei shook his head and sighed: "I have never seen Wang Peng's level of cleanliness, taking antibiotics every day, the microflora in his body has long been messed up by him, and it is a miracle that he is only sick now." ”

Zhou Jie echoed: "The illness of Wang Peng's son and mother may also be related to taking antibiotics. ”

"What antibiotic?" Gu Yanan was attracted by the conversation between Zhou Jie and Gao Fei and asked.

Gao Fei hurriedly answered, and explained the experience of Wang Peng's family in detail, and finally did not forget to add, "Sister Yanan, didn't you see it, when I opened the drawer, I saw the cabinet of antibiotic medicines, which really shocked me, the quantity and variety of some small pharmacies are not comparable, how long does it take for Wang Peng to accumulate so many medicine boxes?" ”

Wang Xiaoxiao also felt incredible, "The state has already clearly stipulated that the abuse of antibiotics is prohibited, and the purchase of antibiotics in pharmacies must be prescribed by a doctor, how did Wang Peng get so many medicines?" ”

Zhou Lao's tone was sad, "There are policies and countermeasures, pharmacies in order to make a profit, even without a doctor's prescription will sell antibiotics to customers, this kind of thing is no secret, it has been reported on the news before, because of the abuse of antibiotics to produce superbugs, Wang Peng did not detect the pathogen of cholera this time, maybe the real situation is worse than cholera......

Before Zhou Jie's words were finished, Gu Yanan had already picked up the phone on his desk and called the laboratory, "Detect whether Clostridium difficile is in the patient's specimens, and isolate and culture to detect toxins." ”

Gu Yanan communicated well with his colleagues in the laboratory on the phone, and when he put down the phone, everyone's eyes in the emergency office were fixed on Gu Yanan.

Wang Xiaoxiao asked in surprise: "Sister Yanan, do you suspect that Wang Peng is infected with the superbug Clostridium difficile?" ”

"It is very likely that Clostridium difficile is a very common type of superbug and is often seen in cases of antibiotic misuse."

Lu Li asked: "Clostridium difficile is generally a nosocomial infection, and Wang Peng has not been to the hospital recently, but just takes antibiotics." ”

Zhou Jie: "Non-toxin-producing Clostridium difficile is found all over the natural environment, and sometimes it is also part of the normal flora of the human body, hypothetizing that there was originally a non-toxin-producing Clostridium difficile in Wang Peng's body, but because he has been taking antibiotics for a long time, the non-toxin-producing Clostridium difficile mutated under the pressure of antibiotic selection, from non-toxin-producing to toxin-producing, which can explain Wang Peng's current symptoms." ”

Gao Fei: "Before the laboratory results came out, we speculated that a variety of anti-superbugs could be formed under the pressure of antibiotic selection, such as multidrug-resistant staphylococcus, vancomycin-resistant enterococci, vancomycin-resistant staphylococcus, carbapenem-resistant Enterobacteriaceae, multidrug-resistant Pseudomonas aeruginosa, Pandrug-resistant Acinetobacter, ESBL-producing Enterobacteriaceae, and multidrug-resistant Mycobacterium tuberculosis...... Wang Peng could be any of them in his body. ”

Just as the members of the emergency team were arguing, the office phone on Gu Yanan's desk rang again, and this time was always Gu Yanan's busiest time.

It was Gu Jiashu who called this time, "Little sister, Wang Peng's mother's condition has progressed too fast, she has been admitted to the ICU, we have used various antibiotics, but we can't control the progression of the disease, what progress is there in your CDC laboratory?" ”

Gu Yanan's heart sank, Wang Peng's mother's situation was completely in line with the symptoms of superbugs, various antibiotics were ineffective and the course of the disease progressed rapidly.

"Brother, I suspect it's Clostridium difficile infection."

"I also suspect that it is, but it will take at least two days to confirm the diagnosis, and it will take at least two or three days to determine which antibiotic works from the isolation of the strain and then to do antibiotic susceptibility tests, which is too late."

"There is literature on case reports of nosocomial infections with Clostridium difficile, and it is possible to treat them according to the treatment protocol in other people's literature, and if there is no other way."

"That's the only way to do it first, I called you, I originally hoped that your disease control laboratory might have identified the pathogen."

"I'll urge the lab to work overtime as soon as possible, and I'll call you as soon as I get the results."

Two days later, the CDC laboratory isolated a strain of toxin-producing Clostridium difficile from Wang Peng's feces, and subsequent antimicrobial susceptibility experiments proved that this strain of Clostridium toxigenes was resistant to all antibiotics on the market.

This also shows that there is no cure for patients infected with this Clostridium difficile.

Under the pressure of Wang Peng's choice to take antibiotics for a long time, a superbug finally formed in his body.