Chapter 240: Offering Your Modest Strength (Part 2)
Because "I Am Not the God of Medicine" came into the public eye, targeted drugs for the treatment of cancer also use gene editing technology.
In vitro editing of CAR-T cells from healthy donors allows them to target cancer and engineer them so that the donor CAR-T cells are not destroyed by the patient's immune system.
In addition to targeted drugs, gene editing technology is increasingly being used for hereditary gene repair in human embryos.
The third generation of test tubes uses gene editing technology to repair the chromosomal balance translocation of human embryos.
This gives many families with chromosomal abnormalities hope of getting pregnant and leaving a healthy offspring.
In medical school, Tan has "played" with many departments, and has learned about gene editing technology in the field of cancer drugs and human embryos, but he has not dabbled too much in parts other than these two fields.
Vinegar Tan has been studying medicine day and night, but with the development of human medicine to the present, there are so many things that can be learned, and I don't want to have that person who can put all the content related to diseases into his own brain.
If the IFT88 mutation gene is not related to dentistry, vinegar Tan may not have heard of it.
Arbor's paper, published in an authoritative journal in the medical field under the leadership of Professor Martens, presents a new approach to the treatment of sensory deficits.
But the paper is experimental, and all the results are based on studies done on laboratory mice.
It is a long process from animal experiments, to human experiments, to the maturity of a treatment modality.
Success in animal experiments does not mean that clinical trials can be conducted.
After all, for the study of various side effects, it takes a long time to determine.
Vinegar Tan understood what Arbor meant by letting her read the paper, but he didn't have much hope.
First, until the time of writing his graduation thesis, he had not heard of the publication of clinical research results on IFT88 gene mutations.
Second, Vinegar Tan did not suffer from congenital anosmia.
Third, just as gene editing technology has passed thirty or forty years from its birth to becoming a reliable medical treatment, gene therapy for anosmia also needs a process from birth to maturity.
Just when Vinegar Tan felt that today's "constructive" medical visit was about to come to an end, Vinegar Tan's nasal tissue section report came out.
Vinegar Tan is suitable for the slice report that Professor Arbor reads together.
From the protein analysis of the sliced tissue, it is true that the olfactory nerve cell cilia contained in the IFT88 protein were not detected.
Vinegar Tan was a little surprised, originally just thinking about breaking the jar, so he came to take a look casually, and actually found the cause directly.
To Vinegar Tan's surprise, Professor Arbor said that this gene editing technology for anosmia has been approved for clinical application.
It's just that it's still in clinical trials.
Due to the peculiarity of the problem of anosmia itself, not many people are willing to do such an experiment.
Originally, it was a problem of not being painful and not itching, and it would not kill people, so naturally fewer people were willing to be the first to eat crabs on the problem of lack of smell.
The base number of patients with anosmia is not very good, and the problems related to IFT88 gene expression should be congenital and often overlooked.
Many congenital anosmia disorders may not seek help from a doctor for the sake of olfactory problems for the rest of their lives.
This has led to Professor Arbor's gene therapy for anosmia that has been running for a year and has not found enough volunteers.
Prof. Arbor asked if he would be interested in participating in the gene therapy clinical trial.
Because in vitro editing technology is used, it is only necessary to inject adenovirus into it like a vaccine.
Vinegar Tan didn't even think about it, so he felt that there was no problem.
Compared to the volunteers who were willing to do clinical trials for Ms. Tan's HIV vaccine,
The clinical trial in front of Vinegar Tan is simply a trivial matter and a piece of cake.
As soon as Vinegar Tan wanted to discuss the specific matters of clinical trials with Professor Arbor, You Mengxiang, who had been accompanying Vinegar Tan to see a doctor, and You Mengxiang, who was in the same mood as riding a roller coaster, directly refused.
There's nothing wrong with gene editing being an effective treatment for anosmia, but a gene therapy that's still in clinical trials isn't what Youmeng wants to see.
This gene-editing technology has been successful in previous experiments on mice, but this does not mean that the same situation is the same in humans.
The gap between laboratory mice and humans is not a little bit bigger, and who knows if there are serious sequelae?
You Mengxiang didn't study medicine, but from the biological knowledge he had studied, he already knew very clearly that the expression of genes was very random.
Genetic mutations can occur if you don't dare to do anything, let alone use external interventions such as gene editing.
Vinegar Tan didn't want to treat his hyposmia, it was You Meng who wanted to strongly ask to bring Vinegar Tan to see a doctor, and he also got Vinegar Tan from St. Moritz to London in various coquettish ways.
Vinegar Tan said that she was originally studying medicine, and her mother was still engaged in biomedical research, and she was willing to contribute her modest efforts to the development of human medicine.
Forgive You Meng for wanting to study law, and the contact with medicine is basically a case of medical malpractice lawsuits.
If Vinegar Tan accepts this trial plan and ends up with adverse reactions or irreversible sequelae, how does You Meng want to deal with himself?
You Mengxiang's attitude was very resolute, so that Vinegar Tan did not sign the volunteer agreement immediately.
Today's "illness", vinegar Tan went from full of disappointment to full of hope, You Meng wanted to go from full of hope to remorse, the same thing, in two people, had completely different reactions.
You Meng thought that it was because he was worried that Vinegar Tan would "hide from the doctor", so he said very firmly that he would accompany Vinegar Tan over.
Normally, hospitals in London are very concerned about the privacy of their patients.
In general, "unrelated" people other than the patient are not allowed to appear in the office.
You Meng thought that it was because Vinegar Tan himself agreed to "let in" that he had the opportunity to accompany Vinegar Tan to see a doctor.
You Meng wanted to be glad that he had come in, and he had followed him from beginning to end, otherwise he really didn't know what the consequences would have to face.
Looking at the unhesitating posture of Vinegar Tan just now, if You Meng was not there, his girlfriend was definitely already an experimental subject of experimental gene therapy for anosmia.
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