At this moment, Liu Kui felt that in the process of returning, he suddenly felt weak, his legs and feet were sore, and he was accompanied by symptoms such as coughing.

"What's wrong with me, all of a sudden? I don't have any strength left! Sore legs and feet! Why don't you help me use your special function to help me search for popular science? Liu Kui looked very tired and said to the Zerg Mother's Hive.

The Zerg Brood agreed to Liu Kui, and immediately began to search and scan.

The search found the following: "Toxoplasma gondii, also known as the three-corpse worm, is an intracellular parasite. It is parasitic in cells, flows with blood, reaches all parts of the body, destroys the brain, heart, and fundus, and causes people's immunity to decline and suffer from various diseases. It is an obligate intracellular parasite, a subclass of coccidia, a order of eucoccidia, an isosporidae of the family Coccidioidae, and a genus of Toxoplasma.

Toxoplasmosis is a human and animal infection caused by a species of Toxoplasma gondii. Toxoplasma gondii is one of the smallest, simplest parasites called protozoa.

Cats and other felines are the definitive hosts of Toxoplasma gondii, which live in the small intestinal epithelial cells of these animals, forming cystic zygotes (called "cyst zygotes" in many articles, which are not accurate) excreted in the feces, which are eaten by other mammals and birds to become infected and develop into cysts in their body tissues. Cyst zygotes and cysts are different stages of development of Toxoplasma gondii.

Although Toxoplasma gondii is not "picky", it can only reproduce asexually in animals other than its final host, and cannot spread its offspring to the outside world. Toxoplasma gondii is a subphylum apical complex, spore powder, eucoccidia, intracellular parasitic protozoa, and its life history appears in 5 morphologies, namely trophozoite tachyzoites; Hemocytes (can survive in tissues for a long time), round or oval, 10~200μm in diameter, can release bradyzoites and schizonts after rupture; Gametophyte and cyst zygote, the first 3 stages are asexual reproduction.

The latter two stages require two hosts for the completion of the life history of sexual Toxoplasma gondii: in the definitive host (cat and feline), the above five types are formed; In the intermediate host (including birds, mammals and humans) there is only asexual reproduction without sexual reproduction, asexual reproduction can often cause systemic infection, sexual reproduction only develops in the intestinal mucosal epithelial cells of the final host to cause local infection, the cyst zygote is excreted by cat feces, and contains two spores after maturity, each containing 4 sporozoites, the structure of the sporozoites is similar to that of trophozoites under the electron microscope, after the cyst zygote is licked by the cat, in its intestine, the sporozoites in the sac escape, invade the mucosal epithelial cells at the end of the ileum for split proliferation, After the cell ruptures, merozoites escape, invade nearby cells, continue to split and proliferate, and some develop into male and female gametophytes, carry out gamete proliferation, form cysts, the latter falls into the intestinal lumen, in a suitable temperature (24 °C) and humidity environment, about 2~4 days to mature, strong resistance.

It can survive for more than 1 year, if it is swallowed by the intermediate host, the sporozoites pass through the intestinal wall after entering the small intestine, and spread with the blood or lymphatic circulation in the cells of various tissues of the whole body to proliferate by longitudinal dichotomy, and a collection of multiple worms can be formed in the cell, called pseudocysts, and the individuals in the cyst are nourishing bodies or tachyzoites, which are common forms of acute cases, after the host cells are ruptured, the trophozoites disperse and then invade other tissue cells, so repeated proliferation, which can cause the death of the host, but more often is that the host produces immunity, which slows down the reproduction of protozoaCysts are formed on the outside of the cyst, called cysts, and the protozoa in the cysts are called bradyzoites, and the cysts can exist in the intermediate host for months, years, or even lifetimes (in a state of overt infection).

There are two types of congenital and acquired toxoplasmosis. Congenital toxoplasmosis occurs only in newborn women and is transmitted through the placental bloodstream. Most infected fetuses or infants are insidiously infected, and some do not develop symptoms until months or even years after birth; It can also cause miscarriage, premature birth, malformation or stillbirth in pregnant women, especially infection in early pregnancy, and the incidence of malformation is high. Studies have shown that the mortality rate for babies born with symptoms or malformations is 12%.

Eighty per cent of those who survive have mental and developmental disorders and 50 per cent have visual impairments. Hydrocephalus, cerebral calcifications, retinal choroiditis, and mental and motor disorders are typical symptoms of congenital toxoplasmosis. In addition, it may be accompanied by systemic manifestations, such as fever, rash, vomiting, diarrhea, jaundice, hepatosplenomegaly, anemia, myocarditis, and epilepsy in the neonatal period. Confluent pneumonia is a common cause of death.

It is usually caused by acute toxoplasmosis infection (often asymptomatic) in pregnant women during pregnancy. There is an innate correlation between the asymptomatic presence of pregnant women and the risk of fetal infection. Prospective studies have shown that the incidence and severity of congenital infections are related to the early and late infection time of pregnant women: pregnant women infected with toxoplasmosis in the first trimester of pregnancy, if they do not receive treatment, can cause 10%~25% of congenital infections, resulting in spontaneous abortion, stillbirth, preterm birth and severe infection of newborns; Pregnant women infected in the second and third trimesters of pregnancy can cause 30%~50% (of which 72~79% can be asymptomatic) and 60~65% (89%~100% can be asymptomatic) fetal infections, respectively. Treatment of infected pregnant women can reduce the incidence of congenital infections by about 60%.

The clinical manifestations of congenital toxoplasmosis are varied. Most babies are born asymptomatic, and some develop retinochoroiditis, strabismus, blindness, epilepsy, psychomotor or mental retardation months or years after birth. Symptomatic patients at birth have a combination of the following: retinal choroiditis; hydrocephalus or small without malformation or anencephaly, intracranial calcification, with spina bifida, meningocele, cleft lip and palate; adrenal gland absence, double polycystic kidneys; conjoined teratogenesis, etc.; convulsions, psychomotor disorders; Lymphadenopathy, hepatosplenomegaly, fever, jaundice, rash, etc. ”

Liu Kui was a little surprised at this moment, and asked the insect target: "I'll go to his brother's!" You mean I have these diseases on the paper? Or do you have the disease? Liu Kui asked the Zerg Nest.

The Zerg Hive just said lightly: "Don't listen to their nonsense, you haven't completely read the information I gave you!" Wait until you're done abusing your belly! ”

After saying that, the Zerg Mother's Hive once again showed the information it had searched for in Liu Kui's mind.

Acquired toxoplasmosis can present differently depending on the site of invasion and the responsiveness of the body. Therefore, there are no specific symptoms and must be differentiated from related diseases.

Most of the patients have some relationship with occupation, lifestyle, and eating habits. Lymphadenopathy is the most common clinical form of acquired toxoplasmosis and is more common in submandibular and posterior cervical lymph nodes. Secondly, Toxoplasma gondii often affects the brain and eyes, causing abnormal manifestations of the central nervous system, and in immunocompromised people, it often manifests as encephalitis, meningoencephalitis, epilepsy and mental abnormalities. The main characteristics of toxoplasmosis ophthalmopathy are retinal choroiditis, which is manifested by sudden loss of vision in adults, hand grasping and eye grasping in infants and young children, slow response to external things, strabismus, iridocyclitis, pigmentitis, etc., bilateral lesions are common, and visual impairment is often accompanied by systemic reactions or multi-organ diseases"