When Liu Kui was hesitating and confused, the Zerg Mother's Hive sent him a lot of information one after another, asking him to figure it out carefully.

Liu Kui is not ready, and the Zerg Mother's Hive has a lot of messy things.

"Acquired toxoplasmosis can present differently depending on the site of invasion and the responsiveness of the body. Therefore, there are no specific symptoms and must be differentiated from related diseases. Most of the patients have some relationship with occupation, lifestyle, and eating habits.

Lymphadenopathy is the most common clinical form of acquired toxoplasmosis and is more common in submandibular and posterior cervical lymph nodes. Secondly, Toxoplasma gondii often affects the brain and eyes, causing abnormal manifestations of the central nervous system, and in immunocompromised people, it often manifests as encephalitis, meningoencephalitis, epilepsy and mental abnormalities. The main characteristics of toxoplasmosis ophthalmopathy are retinal choroiditis, adults present with a sudden decline in vision, infants and young children can see hand eye grasping syndrome, slow response to external things, there are also strabismus, iris cyclitis, pigmentitis, etc., bilateral lesions are common, and visual impairment is often accompanied by systemic reactions or multi-organ lesions.

Most patients with latent infection, when suffering from malignant tumors, undergoing organ transplantation, long-term immunosuppressants, radiotherapy, cytotoxic agents and other iatrogenic immunoimpaired conditions, or congenital and acquired immunodeficiency, such as AIDS patients, pregnant women, etc., can make the invasion site of latent acquired toxoplasmosis and the body's reactivity appear different, resulting in different severity of the disease, ranging from subclinical to fulminant infection. It can be localized or systemic: (1) Lymphadenitis is the most common localized infection, accounting for about 90%. It usually extends to the neck or armpits.

Tough, different in size (generally no more than cm), no tenderness in fractions, no suppuration. It can be accompanied by low-grade fever, headache, sore throat, myalgia, fatigue, etc. Abdominal pain may occur when retroperitoneal or mesenteric lymph nodes are involved. Clinical manifestations may mimic infectious mononucleosis or cytomegalovirus infection, but toxoplasmosis is likely to cause mononucleosis in less than 1% of cases.

Less common cases include myocarditis, pericarditis, hepatitis, polymyositis, myositis, pleurisy, peritonitis, etc. Retinal choroiditis is extremely rare. (2) Systemic infections are more common in immunocompromised patients (such as AIDS, organ transplantation, malignant tumors, mainly Hoggin's disease, lymphoma, etc.) and laboratory workers, etc., and often have significant systemic symptoms, such as high fever, maculopapular rash, myalgia, arthralgia, headache, vomiting, delirium, and encephalitis, myocarditis, pneumonia, hepatitis, gastroenteritis, etc.

Ophthalmoplasmosis is mostly congenital, and acquired may be caused by congenital underlying lesion activity. Clinically, there are blurred vision, blind spots, photophobia, pain, tearing, central vision loss, etc., and there are few systemic symptoms. Visual acuity improves after inflammation resolves, but recovery is often incomplete. Vitreous opacity may be present.

Acquired toxoplasmosis has more complex manifestations than congenital toxoplasmosis. The severity of the disease is related to whether the body's immune function is sound.

1. Most patients with acquired toxoplasmosis in immunocompetent people are asymptomatic, and about 10%-20% of patients have symptoms, and the main clinical manifestations are fever, general malaise, night sweating, muscle pain, sore throat, rash, liver and spleen enlargement, generalized lymphadenopathy, etc.

Lymphadenopathy is more prominent, in addition to superficial lymphadenopathy, mediastinum, mesentery, retroperitoneal and other deep lymph nodes can also be enlarged, and intra-abdominal lymphadenopathy can be accompanied by abdominal pain. Enlarged lymph nodes are hard and may be tender but not suppurating. Signs and symptoms usually last 1 to 3 weeks to disappear. A few cases can last up to 1 year. Individual patients may present with persistent high fever, single cases of retinal choroiditis, transient pneumonia, pleural effusion, hepatitis, pericarditis, myocarditis, Guillain-Barre syndrome, intracranial mass lesions, and meningoencephalitis.

2. Acquired toxoplasmosis in immunodeficient patients, congenital and acquired immunodeficiency patients are at great risk of infection with Toxoplasma gondii, especially the recurrence of underlying infection. In this setting, the lymph node lesions of acquired toxoplasmosis may be subtle, and widespread and rapidly occurring fatal infections may occur, manifesting as high fever, pneumonia, rash, hepatosplenomegaly, myocarditis, myositis, and pelutitis. It can even cause toxoplasmosis. Typical cerebral toxoplasmosis presents subacutely, with headache, hemiplegia, seizures, visual disturbances, confusion, and even coma, and fever and meningeal irritation are less common. Cerebrospinal fluid examination may show a small number of red blood cells, a mild increase in monocytes, a slight increase in protein, and a completely normal or occasionally low glucose. CT scan shows changes in encephalitis, and may also present single or multiple contrast-enhanced mass lesions, less than 2 cm in diameter, and mostly in the basal ganglia. After enhancement, it is ring-shaped or nodular enhancement.

In addition to the above-mentioned diseases: 1. If congenital infection occurs in the first 3 months of pregnancy, about 40% of the fetus may have severe damage, miscarriage, stillbirth or neonatal disease, or lesions or malformations of the eye, brain or liver after birth, such as retinal choroiditis, cataracts, intracerebral calcifications, hydrocephalus, microcephaly, intellectual disability, jaundice and hepatosplenomegaly. Infections that occur in the last 3 months of pregnancy are severe in less than 3% of cases

2. Pregnant women and children with weakened immunity will be most likely to be affected by this parasite compared to others. Therefore, for this kind of people, it is not advisable to have cats at home. And for other cat owners, cat feces should also be disposed of in a timely and hygienic manner. However, it should be noted that it is better for pregnant women not to clean up the cat's garbage tray

3. Lafferty is a parasite ecologist at the University of California, Santa Barbara, specializing in the effects of parasites on the ecology of other animals. Over the years, he has carefully studied areas where the "Toxoplasma gondii" infection is very high and small. In Brazil, two-thirds of women of childbearing age are infected. In the United States, the figure is only one in eight. This parasite is called "Toxoplasma gondii", and when it is transmitted to people, it can cause dramatic changes in a person's personality. Studies have shown that women become more enthusiastic, outgoing, and caring when informed, while men become clumsy and even dull when infected. Both men and women are more likely to feel guilty and insecure when infected.

4. In pets, it is often manifested as: most cats have no symptoms of infection, and a few cats show diarrhea or malaise, which can occasionally cause pneumonia or eye inflammation. Although a few countries in Europe mandate that serum toxoplasma antibody tests are performed early in pregnancy.

Because pregnant women have less chance of infection during pregnancy and fetal infection, the British and American studies concluded that toxoplasma antibody screening is only suitable for specific patients and is not worth routinely doing. Many hospitals are already testing pregnant women for toxoplasma gondii antibodies. However, the quality of the examination is not high, the quality of reagents and screening methods need to be standardized, and many clinicians are not familiar with the significance and correct judgment of serological test results. False positive results and doctors' wrong explanations caused by poor test quality not only waste patients' money, but also cause unnecessary anxiety and anxiety of patients and their families, bring great mental burden, and even do induced abortions that should not be done, causing irreparable losses. appear

In many hospitals, there is no standard for examination and treatment, and the examination is an examination, and the results do not matter, and the treatment of the pregnancy is not considered. In the past two years, I have been approached by a number of people with positive test slips or phone calls asking me what the test results mean: For example, what if I am positive? Should the pregnancy be treated or terminated? Some reports only have "antibody positives" and do not distinguish between antibodies. Sometimes a positive test result turns negative when you go to another hospital. These can be caused by poor quality of inspection reagents and procedures

1. Direct microscopic examination of the patient's blood, bone marrow or cerebrospinal fluid, thoracoascites, sputum, bronchoalveolar lavage fluid, aqueous humor, amniotic fluid, etc. for smear, or lymph nodes, muscle, liver, placenta and other biopsies, Wright's or Ji's staining microscopy can find trophozoites or cysts, but the positive rate is not high. Direct immunofluorescence can also be used to detect Toxoplasma gondii in tissues.

2. Animal inoculation or tissue culture to take the body fluid or tissue suspension to be tested, inoculating the mouse in the abdominal cavity, can produce infection and find the pathogen, the first generation of inoculation is negative, should be blindly passed 3 times. or tissue (monkey kidney or porcine kidney cells) culture to isolate and identify Toxoplasma gondii.

3. DNA hybridization technology: For the first time, domestic scholars used 32P to label a probe containing a specific DNA sequence of Toxoplasma gondii to carry out molecular hybridization with the DNA of cells or tissues in the peripheral blood of patients, and the specific hybridization bands or spots were positive. Specificity and sensitivity are high. In addition, polyase chain reaction (PCR) has been established in China for the diagnosis of this disease, and compared with probe hybridization, animal inoculation and immunological examination methods, it has shown that spring has the advantages of high specificity, sensitivity and rapidity.

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Liu Kui casually read part of it and gave up after not reading it completely.