Li Hao also listened to Director Du Xianyu's explanation, and he corroborated each other with the real technology and alien technology he had learned.

I know that now the organ manufacturing technology has gone through most of the front-end technologies. The final tackling is about to be carried out. This was much earlier than he expected the technology to be completed.

In the past, it was expected that the problem of organ manufacturing could be solved in two years, which was very fast.

After breaking through the first core technology in the laboratory, he expects the technology to be completed within a year. Now it seems that the whole organ will have to wait a long time. However, some functional cells have met the needs of clinical validation.

A smile appeared on Li Hao's face, and he hurriedly asked Du Xianyu: "Director Du, you have successfully completed hematopoietic stem cells, so can you treat leukemia, hemophilia, lymphoma and other diseases now?" ”

If the developed hematopoietic stem cells can solve the terminal disease that has plagued mankind for many years. The impact was just too great.

Director Du Xianyu shook his head and said: "This is our goal in the future, and there are still many technologies that have not yet matured, but the technology for making blood and its blood products has matured." ”

Li Hao immediately extracted the key points in Director Du Xianyu's words. He then asked: "Director Du, are you saying that our company's technology is not yet mature, not that this technology has not been developed." Does that mean that the technology has been developed? ”

Du Xianyu said helplessly: "We have induced the differentiation of hematopoietic stem cells, and various technologies have been successful.

We've done experiments on mice that have been knocked out to give them hemophilia. Hematopoietic stem cell therapy has been validated.

But it has a high mortality rate of 60%. With such a high mortality rate, it is impossible to use it in clinical trials.

Without addressing the specific cause of death, we will continue to conduct animal testing. ”

Zhou Yunsheng listened to them from the sidelines, and she reminded: "Director Du, the cure rate of 40% is already very high for this disease, and the fatality rate of some diseases without this technology is 100%.

And your experimental animals, whether the death caused by the injection of hematopoietic stem cells, or the death caused by this disease. These two points need to be clarified, and the meanings they represent are different. ”

"Mr. Zhou is assured that the medical expert team of our project analyzes the pathological changes of experimental animals at all times. If there is a real discovery, we will not fail to notice. Du Xianyu replied with a smile.

Li Hao sensed that the mortality rate of this technology should not be so high. He asked directly: "Director Du, what is the main cause of the death of the guinea pig?" Even if human hematopoietic stem cells are transfused into mice, its mortality rate is not so high. ”

"Immune rejection, this really can't be helped, we have knocked out the surface antigen of hematopoietic stem cells. But for some unknown reasons, it also causes an attack on the organism's immune system. Du Xianyu said very helplessly.

When Li Hao heard this result, his eyes widened, and he asked puzzledly: "You actually knocked out the surface antibodies of hematopoietic stem cells, why don't you use the cells of mice to culture hematopoietic stem cells, and then conduct experiments." ”

"Our project is organ manufacturing, that is, the industrial production of organs. Our goal is to address immune rejection. Just like the production of industrial goods, identical organs are produced for human transplantation.

Mr. Li, isn't this also your requirement for our biological laboratory. We have been working in this direction. Director Du Xianyu said very firmly.

Under Zhou Yunsheng's foolish gaze, Li Hao covered his face and smiled bitterly. He should have inspected Director Du's technical route a long time ago. I didn't expect such a big mistake.

You must know that Du Xianyu is a typical stubborn character. That's to study human cloning technology, and at the risk of breaking the law, it's exploring technology.

He could only explain with a wry smile: "Director Du, you have misunderstood what I mean, I am talking about the ultimate goal of the project. However, now our understanding of life science is very shallow, and the human immune function has only been explored in its infancy.

We also can't knock out all the proteins on the surface of the cell, and then the cell can't perform its functional tasks. In particular, we lack a holistic understanding of the immune system, and we are not yet able to completely eliminate immune rejection.

The best technical route now is to select the general of the receptor itself and cultivate it into a complete organ. So that we don't need to think about immune rejection. ”

Du Xianyu thought carefully for a while, and he said: "This method requires cultivating his cells from scratch for each different receptor and inducing differentiation.

This process is easy to complete in our lab, but it will definitely involve the application of technology later.

The scientific and technological workers of our project team also have to carry out their own project research and development. It is impossible for me to treat professionals as workers and carry out such low-quality work.

We can't hand this over to anyone else, and each step requires experienced people, someone who can really run the project. Then he is an excellent scientific research assistant, and it is a waste of talent to do this kind of repetitive work. ”

Li Hao directly raised the most critical question: "Director Du, the kind of use of specific human cells to culture organs and some functional cells I am talking about, whether the current technical standards can meet the requirements." What happens when they are implanted into a patient?

It's just using ordinary people to surpass it, and what is the worst outcome? ”

Du Xianyu almost didn't think about it, and immediately answered this question: "We only complete the induced differentiation of hematopoietic stem cells now, such as the induction and differentiation of cells using receptors into hematopoietic stem cells.

I'm sure he's definitely not going to have rejection. That is, there is no impact on human safety. But whether it can divide and differentiate normally in the body. Since I haven't done any experiments, I'm not sure how effective it will be.

However, the experiments we did on mice, as long as the metabolism was normal, there was no interference from other related diseases. Cells implanted into the body will work normally. ”

After answering this question, he continued: "Only ordinary people operate the whole process, then it is better to follow the intelligent program and let the machine operate the process."

Without the intervention of professionals, its success rate is low. We were tested to only get up to 5%.

Hematopoietic stem cells have been tested to differentiate into malformed cells, or seemingly normal but useless organs. That is, there is no biological activity.

We reject this technical route because the detection program is too cumbersome. Until a good detection method is found, this technique has many drawbacks.

Some even have no problems after testing. But when transplanted into living organisms, they are not biologically active.

If you transplant an organ that looks bright and has no effect on the patient. Like hematopoietic stem cells, it's okay, but if it's a large organ, it's not a medical malpractice. ”

Li Hao heard Director Du Xianyu's story, and he finally knew where the technical difficulties in their work were.

But he still felt that his technical route was more correct. The general-purpose organs recorded in the library are implemented in a way that is very difficult for the current scientific and technological base.

Li Hao put forward his own suggestion: "Director Du, I think that the cells of specific people should be used to synthesize the target organs using instruments. This technical route is much easier to implement.

With your abilities, it is easier to find a test with biological activity than to make a universal organ. ”

Du Xianyu also felt that what Li Hao said made sense. He pondered for a while and responded, "Then I'll redistribute the scientific research strength of various project teams." Our main focus is to continue to explore the culture differentiation of totipotent stem cells.

It is just for the medical team and the organ testing project team to explore a better way to detect biological organs.

As for the study of general-purpose organs, only a few scientific research groups are reserved to explore the technical feasibility. ”

Li Hao gave a thumbs up and sighed: "Director Du's way is very good, and he arranges all the work very well. I'm just making a suggestion, you're an expert in this field, just arrange it according to the specifics of the project. ”