017, big fish
Luo Chard looked at Hua Zhenxing for a long time, and finally sighed and said: "I didn't want to say too much, I'm afraid you won't understand some things." ”
Hua Zhenxing said with a straight face: "Just because I can escort you through the wilderness on foot doesn't mean I'm just an ignorant savage." ”
Rochard: "Well, I'm going to say goodbye tomorrow, so I'll tell you today." Filso is a backward, ignorant, chaotic place, but do you know what the most advanced institutions are here? ”
Hua Zhenxing: "The answer to this kind of question raised by you is, of course, the international hospital. ”
The International Hospital in Port Fesom was developed from a 15-year-old refugee tent hospital and has received funding from many international institutions, and is now quite large. It has thousands of hospital beds and even forms a relatively separate and safe area in the city, often overcrowded.
To say that it is advanced refers to those facilities that represent the highest level, with world-class research rooms, operating rooms, laboratories, and monitoring rooms, and hundreds of high-end wards that are not much inferior to those of private hospitals in developed countries. However, these conditions are not available to ordinary people, and most of the general wards and beds in the hospital are in poor condition, and the disposal and observation hall is overcrowded.
Rogrid nodded: "Yes, it not only has state-of-the-art medical equipment and various wards, but also state-of-the-art laboratories and research departments. It's big enough, it's got enough patients, it's got a lot of patients, it's got the best conditions to do drug trials. ”
Hua Zhenxing frowned: "You guys are conducting illegal drug trials here?" ”
Rochard shook his head and said, "It's not us, it's them, and I'm not involved." As for whether it is illegal or not, foreign laws do not govern the port of Africa, and the laws of several miles of countries do not govern international hospitals, not to mention that they do not seem to have clear laws in this regard.
Those in power in this country will not interfere in the affairs of international hospitals, and in exchange for tacit agreement, international hospitals will also ensure their medical safety.
As for drug trials, you can think of almost everything. Originally, many institutions put their laboratories here because it was convenient to do animal testing, for example, the monkeys here were easy to get and there were no animal protection organizations to interfere...... But then, many people realized that there was another kind of convenience.
Do you know the process of developing a new drug? Pharmacological and biochemical analysis is done first, then animal testing, and finally clinical trials. Clinical trials are divided into phases one to four, and the cost is very, very high, and if the research and development fails, it means that all the investment is wasted.
Here, however, the cost is very low. First do a good job of pharmacological and biochemical analysis abroad, and then come here to do the simplest animal testing, and the extent of animal testing sometimes depends on conscience......"
Hearing this, Hua Zhenxing interjected: "Will anyone skip the animal testing stage and do clinical trials directly?" ”
Rohard: "Yes, although this is not a lot, but I have found that I try it in a small dose on a few people, and then continue if there is no serious reaction." But more often than not, animal trials are incomplete, and the data accumulation and observation cycle are not enough, so they go directly to the clinic.
Clinical practice is strictly regulated. For example, in the phase 1 trial, volunteers are usually healthy people. The volunteers of the second to fourth phase trials are all patients with corresponding indications, that is, people with any disease take medicine to treat what disease. The phase II trial also had a control group, that is, people who also had the same disease could not take this medicine, and either took a placebo or other marketed drugs, preferably only a placebo......"
Hua Zhenxing: "You just say the point!" I can go back and look up all of this. ”
Roshand: "Drug trials require a responsibility agreement with the volunteers to ensure that the volunteers are fully informed and that the volunteers are adequately compensated. At the International Hospital in Feso, there are only patients, no volunteers, and they are just data samples. ”
Hua Zhenxing gasped: "Those people don't actually know about it? Not only is there no compensation, but even you are spending your own money to do drug trials for others? ”
The International Hospital is charitable in nature, but it is not a public institution in the country, it was first established by an international rescue organization and receives donations from various institutions around the world. It also charges, and it's expensive, and few people can afford it, except for a few simple glitches.
People who don't have money and want to go to the doctor can apply for assistance and need to fill out several forms. There are many illiterate people here, and even more do not know foreign languages, so the forms are filled out by the hospital staff on behalf of them, corresponding to different charity assistance projects. You can spend no or less money when you get assistance from a certain project, but after all, there are people who spend their own money to see a doctor, at least part of the money.
Rochard nodded, and said, "Actually, the most important thing is not these. Clinical trials here are not standardized, and sometimes in order to get complete data in the shortest time and at the lowest cost, even clinical phases I to III are mixed. ”
Hua Zhenxing: "How to do this?" ”
Rochard: "Direct administration observation, starting with a small dose, some people give the drug and some people don't, those with corresponding diseases are given this drug, and those without corresponding diseases are also given this drug...... In some cases, more comprehensive data is available, even if it is difficult to obtain through formal methods. ”
Hua Zhenxing: "I didn't understand too much. ”
Rochard: "Let's give you an example, contraindications and new indications. Usually the drug trial volunteers can't have other underlying diseases, digestive drugs, can't give it to people with heart disease, and if they don't know what the reaction will be, then they can know now, or they can find out that this drug can treat a new condition. ”
Hua Zhenxing was speechless for a while, and was silent for a long time before asking, "Are the doctors from the International Hospital all involved?" ”
Rochard hurriedly shook his head: "No, no, no, most of the doctors are not involved, they are all here to treat the disease, and their professional ethics do not allow them to do that, and they don't even know it." ”
Hua Zhenxing: "How can you not know? Unconsciously, his tone was already interrogating.
Rochard explains: "The situation at international hospitals is also complicated. Doctors from different countries use drugs from a variety of sources around the world, and it is normal for them not to know a lot of things.
In this world's most backward place, hospitals often see the latest drugs developed from the most developed regions of the world. Some doctors also know that many drugs are not properly sourced, but they have no evidence to question them.
In this place, it would be nice to have medicine to cure diseases, basically using whatever medicine there is. Most doctors are still doing the normal treatment and taking the medication normally according to the instructions. After all, the number of people with problems is in the minority, and even if they use those drugs that have problems, most of them can still cure the disease......"
Speaking of this, he sighed again and said, "There are still many doctors who are not even qualified to question, or are not capable of questioning. For example, doctors from many backward countries are only told that there are the latest advanced drugs in the world, which are donated by non-profit organizations through special channels. ”
Hua Zhenxing: "There is also a chain of contempt within the hospital, or a chain of discrimination. For example, foreign doctors look down on local doctors in a few miles of country, and Dr. Luo, you should be at the top of this chain of discrimination, right? ”
Luo Chard didn't answer this stubble, Hua Zhenxing asked again: "You found these inside information in the hospital and collected evidence and information, so you were hunted down?" ”
Rogrid nodded: "Yes, I have collected a lot of first-hand original materials, and I have also kept some samples, and I have mastered the secrets of certain people. I didn't know that this matter had been exposed, but when you called and said that Jin Datou was going to kill me, I understood at the time. ”
Hua Zhenxing: "What does this have to do with Jin Datou?" ”
Rogrid: "There are strict norms for drug trials, some of which are for the protection of volunteers, and failure to follow those norms may result in a faster and less costly completion of the trial.
But on the other hand, it also has professional requirements, such as how to organize uninformed people to act as volunteers, how to make sure that they are trying one new drug and not another, how to follow up and observe...... All of this requires the help of the locals.
Jin Datou did this, and the Datou Gang organized people to have physical examinations and medical treatments on their own territory, and even regularly let them take drugs that claimed to have a preventive effect, and there were special people to do statistical observations. ”
Hua Zhenxing suddenly remembered something: "Does Charles know, the big man who shot at his accomplices yesterday to cover our escape." His aunt and two younger sisters got sick last year, and I asked you for help. The Big Head Gang organized people to go to the hospital to be guinea pigs, why didn't they help send them to the hospital at that time? ”
Rogrid smiled bitterly: "That's because she's really sick, and it's a deadly infectious disease!" The gang members of the Datou Gang don't know the inside story, only Jin Datou himself knows that he has the money to get it. ”
Hua Zhenxing: "No wonder Jin Datou wants to kill you, and the people who hire him have to kill you." ”
The corners of Rogrid's mouth showed a hint of ridicule: "A mere 30,000-meter gold bounty will be offered, and the golden head will be used as a gunman." The interests involved in this are so great that it is difficult to make several countries go bankrupt. ”
Hua Zhenxing: "You can explain it again." ”
Rohard: "Actually, it's useless for Jin Datou to know, this is not something he can get at all, I'll give you a few small examples." Which group has developed what latest drugs, how much is the cost, what stage of the trial has become, these information in the hands of professional people, can basically judge whether the new drug can be marketed, and the efficacy and profit after marketing.
Knowing this, you know how the stock price will change, and know how the stock will change, so you can operate in advance and use leverage to amplify. And that's just one aspect, if the data falls to a competitor, the value will be even greater. If some information is made public, it will cause scandals and bring huge losses to those pharmaceutical groups. ”
Hua Zhenxing interjected: "Scandal? A scandal of illegal clinical trials? ”
Luo Chard sighed again, shook his head lightly and said: "In Mijian Country, there are not too many people who really care about the life and death of the people of Jili, and the vast majority of people don't even know where the country of Jili is, and they don't even know that there is a country of Jili in the world.
However, it involves the interests of capital, and if it can find operational flaws and attack, it will be a scandal in the capital market. For some large groups, as long as their stock prices fall or rise by a few percentage points, do you know how much the market value will change? ”
Hua Zhenxing: "In this way, how many pharmaceutical groups and how many illegal drug test data have you obtained?" ”
Rochard: "Information is not equal to evidence, and even if you find out that someone is doing this kind of thing, it is often useless, and it is difficult to prove in law that it has anything to do with the people behind it." What I want to grasp is the complete chain of evidence, who is leading what project, what their name is, what identity they have, and what trial data they have.
Then look at which companies are using this data in the documents required by law, have submitted or are in the process of being marketed. I have evidence of more than a dozen pharmaceutical groups and dozens of drugs, all of which are the largest pharmaceutical groups in the world, some in Mikenguo and some in Lobazhou.
I have electronic backups, but electronic data is not enough, and in some cases the original documents are required, and I have some samples that can be stored at room temperature. Samples and materials are usually locked in the office, but yesterday the situation was urgent, and I packed the most important things in my backpack. ”
Hua Zhenxing: "I can escort you to Miri Airport, but in this situation, it will be safe for you to return to Mijianguo?" ”
Rohard: "I'm not unprepared, I won't go back to Mi Jianguo directly." ”
Hua Zhenxing: "What are you going to do?" ”
Rochard avoided answering, raised his head and said, "You want to ask Jin Datou why he killed me, I have already told you." Now it's time for you to tell me, your training is called Nourishing Yuanjutsu, can you teach me? ”
Hua Zhenxing summoned the "system" concentratingly, and found that the completion progress of "task one" had reached more than 90 percent, and it seemed that what Dr. Luo said was basically the truth, but there were still some last situations that had not yet been clarified.