It's not that Fang Hanmin is too modest, if it weren't for the support of the old factory director, not only would he not be able to turn his idea into reality, but it would even be difficult for him to gain a foothold in the Red Star Pharmaceutical Factory.

Even later, at the insistence of the old factory director, Fang Hanmin sat in the position of the director of the Red Star Pharmaceutical Factory, and in the face of the collective resistance of the old qualified scientific and technological personnel, it was a group of young scientific and technological personnel who gave Fang Hanmin great support, so that the plan he formulated could be gradually implemented.

Although what Fang Hanmin said was true, Director Lin pointed out the crux of the problem, "Director Fang, I admit that the support of old leaders and young scientific and technological personnel is indispensable, but I think all this is based on your early contributions, I don't know if you have ever thought that if you have not made achievements that impress the leaders, will the old factory director support you unreservedly?" ”

Fang Hanmin said frankly: "At the beginning, I was in the second workshop of the problem pile, if not solved, may have to close the door, in the workshop and the factory-level technical department can not come up with a solution, someone suggested to the workshop leaders, let me give it a try, through some efforts, I have solved several technical problems in the workshop one by one." That incident caught the attention of the factory leaders, and later, I was transferred to the technical department of the factory. ”

Although Fang Hanmin said it very easily, Director Lin has been engaged in pharmaceutical technology research and development for half his life, even if he doesn't understand the specific situation, he also feels that things are not so simple, and the technical problems that cannot be solved by the workshop and factory-level technical departments have suddenly been solved by Fang Hanmin, which is simply incredible! He couldn't help muttering in his heart, this factory director in front of him, which way did the immortal descend to earth?

Director Lin believes that even if Fang Hanmin graduated from a famous university in China with a doctorate, he also studied and researched basic theories during his doctoral studies, and to solve technical problems in actual production, in addition to the need for solid theoretical knowledge, it is also inseparable from rich practical experience.

Thinking of this, Director Lin couldn't help asking, "Director Fang, let me take the liberty of guessing, which prestigious university are you graduated from with a doctor of pharmaceutical science, right?" ”

Fang Hanmin smiled indifferently, "Director Lin should know that doctors who graduated from prestigious universities are either assigned to national research units, or are higher than state organs, or provincial institutions, at least they also stay in school as teachers and continue to engage in research. ”

"So, Director Fang is a college student who graduated from a prestigious school?"

Every time he faced this question, Fang Hanmin was a little embarrassed, but he was used to it and had already prepared a fixed answer, "I'm very ashamed, I don't have a degree, I'm just a high school graduate." ”

Director Lin was shocked again, "What? High school graduates with no academic qualifications? So ...... do you have the knowledge of pharmaceutical technology? ”

"Haha, Director Lin, don't be surprised, all my knowledge of pharmaceutical science and technology is through self-study. Some people say that interest is the best teacher, I was born interested in pharmaceutical science and technology, and after joining the work, I kept learning and researching, and mastered some modern pharmaceutical science and technology knowledge. ”

Fang Hanmin's explanation, although it sounds very reasonable, but Director Lin will still be skeptical, after all, he not only has a background in this discipline, but also has been engaged in drug synthesis research for more than 20 years, as far as he knows the difficulty of this science, he thinks that a high school graduate who has not undergone special training in theory and practice, if he wants to master the systematic knowledge of modern pharmaceutical science and technology through self-study, it is simply a fantasy!

Lao Lin tried his best to stabilize his emotions, but he still looked very confused, "To be honest, a miracle similar to what happened to Director Fang is the first time I have heard of it in my life, and it completely subverts my cognition. ”

"Director Lin, we feel the same incredible as you, but everything that happened is all around us, and it is a fact that we have seen with our own eyes!"

"We not only learned a lot of theoretical knowledge that we had never learned in school, but also his ability to solve practical problems was an eye-opener for us."

Regarding the remarks of the three subordinates, Fang Hanmin was noncommittal, and Director Lin looked at him with an exaggerated expression, "Director Fang, you have also opened my eyes!" ”

Unconsciously, when the time reached one o'clock in the afternoon, in order not to delay Director Lin's ride, Fang Hanmin raised his glass and proposed to wish him a smooth journey again! Then after the end of the wine party, Fang Hanmin and his entourage sent Lao Lin to the train station, watched him check his ticket and enter the station, and then returned to the unit.

......

Although phased results have been achieved, and the generic drug has also been registered with the regulatory authorities, according to Fang Hanmin's plan, the exploration and trial of the generic drug research group of the technology center is still continuing, with the aim of finding better process conditions and finally eliminating the optical isomer in the synthetic product.

According to Fang Hanmin's instructions, the research group further carried out repeated tests on a variety of conditions, and the obtained racemate was analyzed and tested, and the best test results showed that the cis isomer (active ingredient) accounted for 95%, and the trans isomer (harmful component) accounted for 5%.

"Is there any need to continue experimenting?" Guo Peng, deputy director of the technology center and leader of the generic drug research group, wanted to end the project as soon as possible.

After analyzing the test process and results, Fang Hanmin felt that the synthesis test had been done in detail enough, and continuing the test would only be a waste of resources and would not have much impact on the results, but the separation test of the optical isomer still needed to be continued.

"Director Fang, in the best set of test results, trans isomers account for only 5%, and the active ingredients have been as high as 95%, how meaningful is it to continue to separate and purify?" Guo Peng didn't quite understand Fang Hanmin's thoughts.

"As far as I know, the generic drug we developed, the toxicity and side effects of the active ingredient are minimal, and the toxicity of the trans isomer accounts for 98% of this drug. Is it worthy of the patient taking this medicine? Fang Hanmin asked.

"The trans isomer is only 5% in total, even if its side effects account for 98% of the entire drug, it is not much harm, let's treat this problem, is it too much fuss?"

I didn't expect Guo Peng to say such a thing, Fang Hanmin put down the information in his hand and looked at him very seriously, "Medicines are used to treat diseases and save people, as the development and production unit of this drug, if you treat the toxic side effects of drugs with your attitude, it is irresponsible to patients!" ”

"Director Fang, I think you take the problem too seriously! Many drugs used in clinical practice now, as long as they can cure the disease, who cares about the side effects of the prescribing doctor or the patient? ”

"What you say is true, but you can't use the existing problems as a shield for perfunctory work, we are developers and producers of pharmaceutical products, if we can't minimize the side effects of drugs at the source, what can prescribers and patients do? Moreover, the vast majority of drugs used in clinical practice are old products many years ago, and the generic drugs we are developing now are new products that have only been used in clinical practice in the past ten years. Fang Hanmin said earnestly.

As a doctor of pharmaceutical science from the University of Oxford in the 21st century, the traveler knows that many similar drugs in the previous life have greatly reduced their toxicity and side effects, even if it is a century-old drug like aspirin, through the continuous improvement of process technology, whether it is clinical or people's daily medication, the old dosage form has long been eliminated, and enteric-coated sustained-release tablets that have no irritating effect on the stomach and intestines are widely used.

Guo Peng took a perfunctory attitude towards the toxic side effects of drugs, which made Fang Hanmin doubt his professionalism, but he not only did not realize the seriousness of the problem, but was a little complacent, "There is a folk saying, called 'three points of poison of medicine', according to the proportion of trans isomers in the synthetic product, I estimated it, not to mention three points of poison, not even one point." Therefore, I think that the toxic side effects of our generic drug are already very low! ”

A folk mantra has become an excuse for Guo Peng not to pay attention to the toxicity of drugs, which makes Fang Hanmin cry and laugh, but he can't tolerate this attitude!

"Guo Peng, as scientific and technological personnel engaged in drug development, first of all, your understanding is wrong! The saying that medicine is poisonous has existed since ancient times, but that is the experience of the ancestors in the absence of scientific and technological knowledge, and there is no scientific basis, which can be said to be a kind of helplessness. In addition, we have used modern scientific and technological knowledge to find the source of drug toxicity through experiments, why not do everything we can to find a way to remove this toxicity from the drug? This is the responsibility of pharmaceutical science and technology workers! ”

Seeing Fang Hanmin's distressed appearance, Guo Peng knew that his remarks had disappointed the leader, "Director Fang, I just said it casually, don't take it to heart." ”

"Whatever you want? Guo Peng, you are the deputy director of the technology center and the leader of the generic drug research group, if you have a passable work attitude, will others be more negative? You know, the technology center shoulders the arduous task of implementing the scientific and technological development plan, if there is no pragmatic and realistic scientific spirit, how can the future work be carried out? Have you thought about these questions? ”

"Director Fang, your words are a bit serious, my views on the toxic side effects of drugs have nothing to do with work attitude, and will definitely not affect the specific implementation of the scientific and technological development plan. Actually, I didn't deliberately ignore the toxic side effects of the drug, as far as the generic drug being developed now is concerned, you require 5% of the trans isomers to be completely separated, I think the technical difficulty is too great, and the existing instruments and equipment in the laboratory do not have that kind of conditions at all. ”

After listening to Guo Peng's defense, Fang Hanmin also felt that his words were a bit heavy, and he should be more tolerant and understanding when dealing with young people, and being too demanding may be counterproductive, "I hope I think too much, but I really hope you pay attention to the toxic side effects of drugs." As for the separation and purification test of the active ingredients in generic drugs, it must be continued, and the existing instruments and equipment in the laboratory do not meet the requirements, so you can see what kind of instruments and equipment need to be added, give me a list, and I will solve the remaining problems. ”

A few days later, Guo Peng presented a new test equipment purchase list to Fang Hanmin, and after reading it, he pointed to a set of equipment in the list and asked Guo Peng: "How much do you think this equipment has improved the separation effect?" ”

"I guess I can increase it by one or two percent."

Fang Hanmin said very calmly: "First of all, no one can say whether this equipment can increase the separation effect by one or two percent; In addition, even if this effect can be achieved, there is still a certain distance from the ideal goal. ”

"I think this solution has the hope of further improving the separation effect, and I have no other way but this solution." It seems that Guo Peng has done his best.

After thinking for a moment, Fang Hanmin's brows furrowed, "I think it is necessary to adopt a new process and equipment, and simply take one step." ”

"One step? Director Fang, I don't understand what you mean. ”