In the 21st century, optical disaggregation technology has been very mature, and there is more than one specific method, whether during the doctoral study at Oxford University, or later engaged in new drug creation work in the R&D center of RGP company, in the laboratory of the previous life, personally implemented the separation operation of optical isomers, Fang Hanmin is familiar with this technology.

In fact, when the test results found that the generic drug contained optical isomers, Fang Hanmin thought of using optical splitting technology for separation and purification, but considering that this technology is too advanced, under the existing conditions in China, this technology will face many difficulties in the specific implementation process, so he had to decide to use traditional methods to operate.

However, the test results during this period of time showed that the traditional process was not suitable for the separation and purification of optical isomers at all, which forced Fang Hanmin to think of optical splitting technology again, which is what he called one-step implementation.

After listening to Fang Hanmin's idea, Guo Peng and several other scientific and technological personnel looked at each other, they felt that although this technology was advanced, it could not be implemented, because they had listened to the teachers of the relevant courses introduce this technology during their college years, but it belonged to the cutting-edge and cutting-edge technology, even in developed countries, only in laboratories with extremely high specifications, optical dismantling of optical isomers could be carried out.

"Director Fang, we haven't heard of any unit in China that has developed this technology, do you think there are conditions for the implementation of optical splitting in our technology center?" Because he felt that the technical difficulty was too great, Guo Peng was obviously not interested in it.

Fang Hanmin did not answer Guo Peng's question directly, but asked, "Have you heard of this technology before?" ”

"When I was in college, in the advanced organic chemistry course, the teacher briefly introduced the principles of optical resolution technology, but it was the cutting edge of technology, and we only heard about it."

"Oh, you know how it works? That's even better! Because it was a bit unexpected, Fang Hanmin seemed a little excited, "You know, although the trans isomer content in the synthetic product is not much, but the toxic side effects are very large, in order to make this generic drug benefit the majority of patients, it is necessary for us to separate the trans isomer to eliminate the toxic side effects of the drug to the greatest extent." ”

"Director Fang, we understand the importance of this work, the technical scheme you proposed is also very advanced, the key is the optical resolution method to separate trans isomers, not only the technical difficulty is too great, but also the drug research and development institutions nationwide do not have the relevant test conditions, our technology center will not be able to carry out optical resolution tests."

How could Fang Hanmin not know the technical difficulty of optical splitting? However, the traverser had personally engaged in the actual operation of this technology in his previous life, and he was very familiar with the technical details of optical splitting, while Guo Peng and others did face great challenges in terms of technology.

The technology center of Red Star Pharmaceutical Factory was built by Fang Hanmin himself, he knows the family background of the technology center well, he knows that with the existing hardware facilities of the technology center, there is no condition to carry out optical split tests, even those large scientific research institutes engaged in drug research in China, so far there is no precedent for carrying out such tests, on the one hand, because the technical difficulty is too great, in addition, the lack of advanced instruments and equipment in the laboratory is also the main reason.

Although Fang Hanmin understands the concerns of Guo Peng and other scientific and technological personnel, he has his own opinions, "It is true that no domestic scientific research institutions have used this technology in practice, but I want to emphasize that everything has a first, why can't we be the first to eat crabs?" As for hardware facilities such as instruments and equipment, although the existing conditions are not applicable, we can find a way to solve it. ”

"Trying to figure it out? It's easy to say, but how to solve it? Director Fang, do you know how much it costs to purchase those cutting-edge scientific research instruments? The point is that even if you have money, many instruments and equipment may not be available in China! Guo Peng has always been not optimistic about this matter.

"Haha, you're too optimistic! The Red Star Pharmaceutical Factory does have money, but that money has other uses, and the budget for technology development this year has been spent, and the funds have not yet been secured to buy new instruments and equipment. ”

"Isn't that it? In that case, why should you ask for hardship? Although Guo Peng and Fang Hanmin have a superior-subordinate relationship, they are the same age, and they have worked together for more than ten years, and the two have a lot of common language in technology, so he has always spoken to Fang Hanmin more casually.

"It's man-made. There are indeed many difficulties in carrying out optical split experiments, but our goal cannot be changed! You just have to get ready, and I'll figure out the rest. ”

Guo Peng knew that this was Fang Hanmin's task to him, Fang Hanmin was not only the factory director, but also technically worthy of Guo Peng's teacher, if he found a reason to treat it negatively, the nature would change.

After thinking for a moment, Guo Peng had no choice but to nod in agreement. ......

Two days later, at about nine o'clock in the morning, Director Yuan of the Municipal Industrial Bureau was in the office to check the statistics of the enterprises under his jurisdiction in the first half of the year, and suddenly heard someone knocking on the door, he casually responded, "Please come in!" ”

Seeing the person who pushed the door in, Lao Yuan was slightly surprised, "Han Min? What are you doing here? ”

"Old leader, it seems that you don't welcome me!"

Lao Yuan stood up and hurriedly explained: "No, no, no, I didn't mean that, I mean you, a busy person, how can you have time to visit me?" ”

No wonder Director Yuan was surprised, in addition to dealing with administrative affairs, Fang Hanmin spent all his energy on technology development, Lao Yuan was transferred to the Municipal Industrial Bureau as a leader for more than half a year, Fang Hanmin just took advantage of the opportunity to hold a meeting with the Industrial Bureau, visited the old leader twice, and today is the first time he made a special trip to visit the old leader.

Facing Lao Yuan's doubts, Fang Hanmin said with a smile: "No matter how busy you are, you should take time to visit the old leader, it's been so long, I'm afraid you'll be too careful!" ”

Director Yuan said solemnly: "Am I that kind of person? Others don't know, I don't know that you're busy all day, how can you have time to take care of these insignificant things? ”

"Just kidding, don't take it seriously. Old leader, I came to you today, I have nothing to do but go to the Three Treasures Palace! Fang Hanmin stopped going around in circles.

"I'll just say, can you come to me if there's nothing to do? What's up? Sit down and talk. In addition to the relationship between superiors and subordinates, Lao Yuan and Fang Hanmin can be called New Year's friends, and when he was the director of the Red Star Pharmaceutical Factory, he did not treat Fang Hanmin as an outsider.

After the two sat down face-to-face next to the coffee table, Fang Hanmin took out a document from the bag he carried, "Director Yuan, there is a report here, please take a look." ”

Lao Yuan took it, looked at it carefully from beginning to end, and then looked at Fang Hanmin, "Wasn't the technology center of the Red Star Pharmaceutical Factory built a long time ago?" I remember that when the factory-level leadership team held a meeting to discuss this matter, some team members did not agree to spend so much money on scientific research and development, or I decided to make a decision against public opinion, why do I want to buy instruments and equipment now? And need such a large amount of money? ”

"Old leader, those instruments and equipment have been used to the fullest in the past, and now the instruments and equipment that I plan to buy have new uses."

In fact, Fang Hanmin wrote very clearly the purpose of the instruments and equipment to be purchased in the report, and in order to deepen the impression of Director Yuan, he told Lao Yuan about the purpose of those instruments and equipment in person.

Director Yuan is very familiar with the scientific and technological development plan of the Red Star Pharmaceutical Factory, because it was proposed by Fang Hanmin when he was the director of the Red Star Pharmaceutical Factory and approved by him personally. After listening to Fang Hanmin's story, he asked with interest: "So, you have already started to implement the scientific and technological development plan?" ”

"Yes, we started the experiment around the Spring Festival."

"Just do it, you're such a resolute person! I remember that in your planning, the short-term goal was to generic the patented drug, where is the trial now? ”

"After more than half a year of testing, we have prepared almost the same API as the original patent in the laboratory, and registered it with the regulatory department."

Lao Yuan was surprised, "Your experiment is progressing fast enough!" As far as I know, it is difficult to produce results in imitation experiments of this difficulty without a year or two. However, since the patented drug has been successfully imitated, why do you need to add such advanced instruments and equipment? ”

Fang Hanmin told Director Yuan that there are trans isomers in APIs that have great toxicity and side effects to the human body, "We applied to purchase these cutting-edge instruments and equipment in order to separate the trans isomers in APIs." ”

Director Yuan thought for a while, "Have you conducted an anatomical analysis of the same drug produced by a foreign company, and is there such a trans isomer in the imported drug?" ”

"We have done an anatomical analysis, and the same imported drug contains this trans isomer."

"Separating this trans isomer is not only technically difficult, but also requires advanced instrumentation and equipment, so why go ahead when you're already doing as well as foreign companies?"

It seems that most people think that more is better than less, the same problem, Guo Peng and others in the technology center have raised to Fang Hanmin, and now Director Yuan also said so, Fang Hanmin has to seriously explain, he must get the understanding and support of the superior leaders, otherwise, the funds for the purchase of advanced instruments and equipment can not be solved, then nothing can be done.

"Director Yuan, when we imitate patented drugs, we are actually standing on the shoulders of our predecessors, why can't we do better than them? If we are satisfied with just doing as well as our predecessors, we will never innovate! ”

These words deeply moved Lao Yuan, he couldn't imagine that a person without a formal education could realize such a profound truth, he originally thought that Fang Hanmin was a self-taught professional and technical personnel, and only knew how to study technology, it seems that he did not have a comprehensive understanding of Fang Hanmin before.

"Hanmin, you said it so well! Standing on the shoulders of predecessors, there should be breakthroughs and innovations! The Red Star Pharmaceutical Factory led by you has set an example for the city's industrial enterprises, and they should all learn from the Red Star Pharmaceutical Factory. As the leader of the Municipal Industrial Bureau, Lao Yuan hopes that his subordinate enterprises will be like the Red Star Pharmaceutical Factory, and rely on innovation to drive the development of enterprises.

Fang Hanmin has always been low-key and never likes publicity, in addition, the purpose of his coming to Lao Yuan today is not to promote the performance of the Red Star Pharmaceutical Factory, "Director Yuan, let's talk about it after summarizing the promotion, what I want to know is, after reading this report, when will the bureau give us the funds to purchase instruments and equipment?" ”

Lao Yuan scratched his head with his hand, feeling very embarrassed, "What about this?" Ouch, you know, this year's budget has been used up, it's October, wait another three or four months, and when next year's budget comes down, things will be easy. ”

Fang Hanmin was anxious when he heard this, so he ignored the relationship between his superiors and subordinates, and said very anxiously: "Next year's budget, will you have to wait for three or four months?" Director Yuan, you're not prevaricating, are you? ”