was politely rejected by Mr. Xia, although Fang Hanmin was a little embarrassed, but he didn't care too much, after all, Lao Xia's qualifications were there, he was old, he was about to retire, and he couldn't stand the fatigue of the business trip, these are all facts, for this kind of veteran leader, of course Fang Hanmin can't be reluctant.

Let Lao Xia come forward to contact the design unit, mainly because he has dealt with the design agency and is familiar with the routines and rules, in addition, Lao Xia is the chief engineer of the Red Star Pharmaceutical Factory, Fang Hanmin feels that he can contact the design department by him, which can be valued by the other party, which is conducive to speeding up the design progress. Now, Lao Xia refused to accept this task and chose to stand by and watch, and Fang Hanmin had to find someone else.

Sitting at the desk, Fang Hanmin went through the familiar middle-level leaders in his mind, and did not find a suitable candidate to contact the pharmaceutical design unit, so he called the elder Hou of the personnel department and asked him to check the personnel file to see who was the scientific and technological personnel of the engineering profession among the section-level cadres in the whole factory.

After an hour, Section Chief Hou reported the results to Fang Hanmin, there are more than ten scientific and technological personnel with engineering expertise in the whole factory, but only one person meets the requirements, "This person's name is Xu Hui, as far as I know, he is now the deputy director of the technology center." ”。

As soon as he heard the name, Fang Hanmin was too familiar, "Yes, Xu Hui is one of the two deputy directors of our technology center, and he is also the head of the catalyst preparation and recovery processing section, but I didn't expect him to study engineering." ”

"According to the archives, he studied chemical engineering at university."

"Great! That's him. ”

The next morning, Fang Hanmin talked to Xu Hui and asked him to be the director of the preparatory office for the generic drug production project.

Xu Hui is the second batch of college graduates after the resumption of the college entrance examination, a few years older than Fang Hanmin, although he is studying engineering, but he is introverted, not good at dealing with outsiders, I feel that now in a safe corner, it is good to manage the catalyst preparation and recycling process, "Director Fang, I am afraid that I will not be able to do the job of the director of the preparatory office." ”

"Isn't your major chemical engineering? I used to be a workshop technician and independently managed the catalyst section, and now I want to prepare for the construction of an industrial production line for generic drugs, and I think it is most appropriate for you to be responsible for the preparatory work. ”

"But I won't make a decision!" Xu Hui told the truth.

"The preparatory process is not yet at the decision-making stage, you just need to contact the design department, achieve a seamless connection with them, and provide the design company with all the information they need, depending on your professional background, this work should not be too difficult for you."

"You mean, I'm mainly responsible for dealing with the design department?"

"In the preparatory phase, that's the main thing to do."

Xu Hui majored in chemical engineering, and during the graduation project, under the leadership of the teacher, they interned in a large design institute for most of the semester, and completed the graduation project there. After knowing the content of the work in the preparatory stage, he dispelled all his doubts, "I studied engineering, let me do things within the scope of my major, and finally met the job of the professional counterpart!" ”

After accepting the task, Xu Hui became the director of the preparatory office for the construction of the generic drug production line, but the catalyst section of the technology center was leaderless, which involved the preparation and recovery of palladium carbon catalysts.

In terms of personal feelings, Jiao Tiehui is Fang Hanmin's best friend in the Red Star Pharmaceutical Factory, but when Fang Hanmin wants to use his right-hand man, Jiao Tiehui is still a little resistant, "Da Liu is a key member of the Labor Discipline Supervision Office, you transferred him away, and I won't be able to do this job in the future!" ”

Fang Hanmin disagreed, "Look at what I said, you are the director of the Labor Discipline Supervision Office, even if Da Liu is your right-hand man, without him, you won't be able to work?" ”

Jiao Tiehui hurriedly explained, "No, no, no, I mean, there are thousands of people in the whole factory, and we will definitely not be able to take care of it without the backbone of Da Liu!" ”

"If you don't have enough manpower, you can choose someone again, among the employees you are familiar with, as long as there are people who are decent, fair, and upright, you can say hello to the personnel department and transfer him to your office." I know that you have worked with Da Liu for a long time, and you have a tacit understanding, but the catalyst section of the technology center needs management personnel, Da Liu used to be a team leader there, and now there is a shortage of a section leader, I think there is no more suitable person than him, in order to work, you have to endure the pain of love! ”

Jiao Tiehui was very supportive of Fang Hanmin's work, but because things came too suddenly, he couldn't accept it in his thoughts, so he had resistance, after Fang Hanmin explained the reason clearly, he blamed himself a little, "Hey, what kind of painful love, we are all employees of Red Star Pharmaceutical Factory, no matter who it is, we must focus on the overall situation, not to mention Da Liu, even if I need to do something, I will absolutely obey the leader's arrangement." ”

"I'll just say, how can you, the most sensible person, be emotional? You tell Da Liu to report to his new post as soon as possible. ”

......

After several inquiries, Guo Peng and others learned that a manufacturer specializing in the production of test equipment in other provinces had the test equipment they needed, and in order to hurry, Fang Hanmin asked them to send someone from the research group to buy the equipment back as soon as possible.

Guo Peng and others did not dare to slack off, and sent two staff members from the research group, and returned with the test equipment four days later.

Fang Hanmin went to the laboratory to guide the installation and commissioning of the new test equipment, because the previous tests were operated under normal pressure, in order to eliminate the nervousness of the research group staff on the pressure operation, after being ready, Fang Hanmin personally demonstrated, as the temperature rises, the reading of the pressure gauge is also changing, when the pressure reaches about two kilograms, he decisively stops the heating, so that the test device continues to run.

After the indicators stabilized, Fang Hanmin asked the staff of the research group to work with him to pay close attention to the operation of the test and make a detailed record of the test process.

For several days, Fang Hanmin continuously demonstrated the operation under the conditions of 3 kg, 4 kg and 5 kg pressure, and the staff of the research group also basically mastered the operation essentials.

Fang Hanmin handed over the test to Guo Peng and others, and asked them to repeat the stability test under these conditions, "Director Fang, doesn't the test pressure need to be further increased?" ”

"It is not difficult to see from the results of these tests that pressure does have an effect on the formation of trans isomers, but at pressures above three kilograms, this effect becomes less obvious. Therefore, I don't think there is a need to further increase the pressure on the system, after all, the higher the pressure, the greater the accompanying safety risk, and the benefits of further increasing the pressure are not proportional to the risks faced. ”

The test results show that in the pressure range of three kilograms, the trans isomer decreases with the increase of pressure, which indicates that the system pressure is indeed conducive to inhibiting the formation of trans isomers.

After a synthesis reaction at a pressure of three kilograms, the generic drug obtained only one percent of the trans isomer, which is a full one percent reduction compared to the original result, which is an exciting discovery!

A series of subsequent stability tests have achieved basically consistent results, and through this effort, the first technical node proposed by Fang Hanmin to be improved has been further optimized.

Since then, under the guidance of Fang Hanmin, the research group has found more reasonable process conditions in optical splitting and phenylethylamine recovery tests, which not only saves 3% of the amount of splitting agent, but also increases the recovery rate of the splitting agent from 99% to 99.8%.

After optimizing the process technology of the three nodes, through accounting, compared with the original test results, the production cost was reduced by 15%, which was even beyond Fang Hanmin's expectations, at least the results obtained from the laboratory can show that he expected to make the generic drug into a drug with significant efficacy, low toxicity and side effects, and high quality and low price, this goal has been achieved! ......

The laboratory development of the generic drug project has finally ended, and after a busy year, all the staff of the research group can finally breathe a sigh of relief! However, Guo Peng and other scientific and technological personnel can not stop for a moment, in addition to a large amount of data to be sorted out, but also to write a test summary report, which is the work that must be done after the end of each subject.

The preparatory work for the construction of the production line is progressing steadily, and with the efforts of Xu Hui, director of the preparatory office, the design institute has completed the basic design on time, but before the engineering design is carried out, there was a serious disagreement between the design institute and the Red Star Pharmaceutical Factory on the design fee.

The reason is that Fang Hanmin proposed that the generic drug production workshop in the future should be designed and built according to GMP standards, but the Provincial Pharmaceutical Design Institute believes that this requirement is very advanced, and the design department needs to spend more energy and time to familiarize itself with the relevant specifications, so they proposed that the design fee should be increased by 50% on the basis of the original plan.

"Are these people in the design institute still unreasonable? Isn't it just about designing a GMP workshop? They raised the design fee by 50% all at once, which is a money grab! After listening to Xu Hui's report, Fang Hanmin immediately became angry.

"Director Fang, the GMP standard workshop is a new thing in the domestic pharmaceutical industry, and the design institute is relatively unfamiliar, I estimate that they need to refer to a lot of foreign materials in the design process, learn a lot of new knowledge, and may need to pay more in energy and time." Because Xu Hui was also in contact with GMP for the first time, he expressed his understanding of the requirements of the design institute.

Fang Hanmin does not agree with this, in the 21st century, GMP has already become the standard of the pharmaceutical industry, those standards are from the World Health Organization, open to all countries, regardless of design or production management, in accordance with the requirements of GMP standards one by one, without spending too much extra energy.

However, Fang Hanmin is a reasonable person after all, and he partially agrees with Xu Hui's statement that it does take some time to familiarize himself with a new thing, but it is categorically unacceptable to increase the design fee by 50%! "You tell the design institute that Red Star Pharmaceutical Factory can accept a maximum increase of five percent in the design fee, and the time will be extended by one month, otherwise there is no need to talk about it!"

Xu Hui is an honest man, he has never dealt with the outside world before, he feels that the gap between the two sides is too big, even if he tells Fang Hanmin's meaning to the design institute now, the other party will not agree, "Director Fang, why don't you come forward to interview the people of the design institute in person and see if you can convince them?" ”

Fang Hanmin thought for a while, "Well, it's time to meet with the other party, you invite people from the design institute to come to the Red Star Pharmaceutical Factory, and I will meet with them." ”

"Okay, I'll call them in a moment. In addition, I think we should continue to cooperate with the design institute, because they have already completed the basic design, and if we find another design agency, the preliminary work will be in vain. ”