Because the application and approval process of the relevant procedures is more complicated, the time required is difficult to predict, and the construction of the preparation workshop is not a matter that can be completed in one or two months, on the clinical trial of generic drugs, Xu Xin suggested that separate actions, on the one hand, the relevant departments of the Red Star Pharmaceutical Factory should seize the time to prepare for the production of preparations, in addition, should cooperate with a pharmaceutical company with complete procedures, launch generic drug preparation products as soon as possible, and strive to carry out clinical trials as soon as possible.

Fang Hanmin fully agreed with Xu Xin's suggestion, and he handed over the task of finding a partner to Xu Xin, "You are the sales section chief, and you know the most about outside companies, which company do you think is the most suitable as a partner of Red Star Pharmaceutical Factory?" ”

"Director Fang, I don't know which company is suitable as a partner of our factory, and this matter cannot be decided by me, I think the cooperation unit should be determined through a similar bidding method."

"Of course, the bidding method is good, but for the bidding of the same industry across the country, from the issuance of bids to screening and review, to the final confirmation, this workload is not small! Not to mention the time-consuming and trouble-consuming, I am afraid that the final result will backfire. ”

Fang Hanmin's worries are all reasonable, domestic counterparts basically know the market value of this generic drug, if the national bidding, willing to cooperate with the Red Star Pharmaceutical Factory of the pharmaceutical companies there are twenty or thirty, to choose one as a partner in so many enterprises, can only be judged through analysis and comparison, whether Fang Hanmin or others, there is no time and energy to do this work.

After some discussion, everyone agreed that the bidding should be controlled in a small range, and only familiar units or pharmaceutical companies that have had business dealings with Red Star Pharmaceutical Factory should be allowed to participate in the bidding.

At the meeting, Fang Hanmin also made a division of labor and arrangements for other matters, and urged everyone to take their own responsibilities, act vigorously and resolutely, and take practical actions to bring generic drugs to the market as soon as possible.

As Mr. Xia said, Red Star Pharmaceutical Factory has been engaged in the production of APIs, has not directly faced the preparation products of medical institutions, has never dealt with medical institutions, and seriously lacks resources in this regard, although a decision was made, but the first problem Fang Hanmin encountered was to find a medical institution willing to do clinical trials, which was a task he shared.

Without social resources, Fang Hanmin had to try his luck, and he wrote letters to several pharmacy experts he met at the academic exchange meeting, stating his ideas, and asking them to help recommend or contact medical units that were willing to cooperate.

Ten days later, Fang Hanmin received replies from experts one after another, and he was greatly disappointed, because several experts who replied admitted that although they were engaged in pharmaceutical research and had some fame in the industry, they had nothing to do with medical institutions, and they could not do anything about the difficulties faced by Fang Hanmin.

At about three o'clock in the afternoon of this day, the staff sent another letter to Fang Hanmin, and the mailing unit at the bottom of the envelope showed that the letter was sent from a well-known medical research institute in China.

Hello, Comrade Hanmin!

First of all, congratulations to Red Star Pharmaceutical Factory for taking the lead in successfully developing this generic drug in the country!

Please forgive me for being a little late. I am very embarrassed by the things you entrusted, don't look at me I have done a lifetime of drug research, but I have never dealt with a medical institution with good qualifications, but I don't want to live up to your trust, so I mobilized my relatives and friends to help, as a result, an old classmate of mine, really found such a medical institution, it is said that not only has high qualifications, but also has done a lot of clinical trials, and has rich experience. After initial contact, the other party expressed its willingness to cooperate with you, but the conditions and details of cooperation need to be discussed by both sides.

The signature of the letter is Fei Liangyong, this Professor Fei is a well-known drug synthesis expert in China, highly respected in the industry, Fang Hanmin's hydrogenation reduction process is Professor Fei's scientific and technological achievements, at the academic exchange meeting the year before last, he gave a high evaluation to Fang Hanmin's paper and keynote speech, and admired Fang Hanmin's talent very much, and Fang Hanmin has a lot of origins.

Professor Fei's letter gave the extremely depressed Fang Hanmin hope, and he immediately dialed Professor Fei's phone, in addition to expressing his gratitude to Lao Fei, he also decided to go to S City as soon as possible to interview people from clinical trial institutions.

The factory staff booked a train ticket for Fang Hanmin for the next day, and two days later, when Fang Hanmin arrived in S City, he decided to visit Professor Fei first, and on the phone, the two agreed to meet at a hotel near Lao Fei's unit.

At about six o'clock in the evening, Fang Hanmin waited for a while in a small private room on the second floor of the hotel, Lao Fei pushed the door in, Fang Hanmin got up to greet him, held the guest's hand and said excitedly: "Professor Fei, we meet again, we will be fortunate to meet!" ”

"yes, I haven't seen each other for more than two years, but you've changed so much in the past two years! I heard that you not only became the director of the Red Star Pharmaceutical Factory, but also took the lead in copying this drug in the country, you are indeed young and promising! ”

"Professor Fei has won the award. Actually, I am not interested in administrative management, and although I am a factory manager, my main focus is still on scientific research. As he spoke, Fang Hanmin gave the guests to the table.

"That's right, you have a talent for scientific research, don't waste your talent because of administrative affairs, try to leave the administrative work to the deputies."

"It's not talent, it's just that I'm interested in scientific research. Professor Fei, we can't just talk, let's order the dishes first, you are a local, you can arrange the dishes. Fang Hanmin put an exquisite menu in front of the guests.

"I don't know how to order, and I always listen to other people's arrangements wherever I eat, so don't embarrass me." Professor Fei handed the menu to Fang Hanmin again.

A senior technical expert like Lao Fei generally doesn't care about some small sections of life, Fang Hanmin felt that he was not deliberately polite, so he followed the waiter's suggestion and ordered four special dishes in the restaurant, plus a soup, because he knew that Professor Fei didn't drink liquor, Fang Hanmin ordered a bottle of high-grade dry red.

"As far as I know, the patent protection of this drug is about to expire, including our unit, there are five or six domestic scientific research institutions and relevant universities want to imitate this drug, no one thought that now it is actually imitated by a local company, this news will definitely cause a shock in the industry. With you as the technical leader, I don't doubt the technical strength of Red Star Pharmaceutical Factory, but what I want to know is, how did you come up with the idea of copying this drug? Professor Fei did not leave the line in three sentences, although he did not admit it, he still had some doubts about the results achieved by the Red Star Pharmaceutical Factory.

At this time, the dishes have been served, the wine has been poured, and the two are chatting while eating.

Fang Hanmin explained the original intention of developing this generic drug, "Red Star Pharmaceutical Factory only has three or four products in total, we believe that the company has a single product and poor anti-risk ability, and the development of new products is to increase the company's anti-risk ability." Before deciding on the development of this generic drug, we found through research that the drug has a good market reputation and patent protection is about to expire, making it an ideal target for new product development. ”

If he hadn't personally listened to Fang Hanmin's speech at the academic exchange meeting the year before last, Professor Fei would not have believed that a local enterprise with thousands of people could have such advanced awareness and keen sense of smell.

Lao Fei believes that even if the well-known national medical research institute where he is located, top medical experts like him have only realized the importance of this drug, but due to the cumbersome decision-making mechanism and slow action, this drug will be included in next year's scientific research and development plan at the end of this year.

For those low-level scientific research institutions and large pharmaceutical manufacturers, they will not even have such awareness!

As the leader of the expert group of the synthesis specialty of the Pharmaceutical Research Institute, Professor Fei wanted to discuss the synthesis process of some generic drugs with Fang Hanmin, but considering the sensitivity of technical secrets, Lao Fei dispelled this idea, and he asked instead: "You are an API production unit, why did you suddenly think of doing clinical trials?" ”

"Because the company's product categories are too small, which is not conducive to participating in market competition, the next step of Red Star Pharmaceutical Factory wants to do a product chain and increase product variety, we think that generic drugs are just an opportunity, and we decided to produce preparations at the same time as raw materials, so we want to use our own preparations to do clinical trials and compare them with the products of patent-holding companies."

"That's a bold idea." Professor Fei nodded slightly, "But I want to remind you that clinical trials are a very serious matter, and the curative effect obtained is a real result, if the clinical data is not ideal, it will have an adverse impact on the preparations and APIs you produce." ”

Fang Hanmin said a little mysteriously: "Don't hide it from Professor Fei, we also have a purpose that is inconvenient to disclose to the public when we do clinical trials. ”

"Oh, what other purpose do you have? I wonder if you can tell me a little bit of information? Driven by curiosity, Lao Fei couldn't help asking.

"On the basis of the original patent, we have improved the synthesis process, at least from the API testing data, the active ingredients of the drug have increased by two or three percentage points compared with the original patent, and the corresponding harmful ingredients have also been reduced a lot."

Lao Fei felt incredulous, "What? In the laboratory of your factory, not only has the process technology of the original patent been improved? And with such good results? ”

"Professor Fei, although the scale of the newly built laboratory in our factory is not too large, it is not like the old one you saw when you went to us to preside over the hydrogenation process technology appraisal meeting, in recent years, the laboratory has not only purchased new instruments and equipment, but also the newly purchased instruments and equipment are very advanced."

Lao Fei didn't seem to be satisfied with Fang Hanmin's explanation, "I'm afraid things aren't that simple, right?" Instruments and laboratory hardware facilities, as long as there are funds, can be added at any time, but to make results, in addition to modern instruments and equipment, the key needs talents! ”

Lao Fei's Pharmaceutical Research Institute, which brings together hundreds of professionals related to drug research, has just realized the importance of imitating this drug, and Fang Hanmin has not only successfully developed it, but also made significant improvements on the basis of the original patent, which is completely beyond Professor Fei's expectations.

Through his previous understanding of Fang Hanmin, Lao Fei knew that Fang Hanmin's technical level was very high, but he didn't believe that Fang Hanmin could make such a big result by himself. In addition, Professor Fei has read the patented technical information of this drug, and even if he is measured by his level, he also thinks that its synthesis is not small, and it involves a variety of processes, is Fang Hanmin a technical all-rounder?

Although he heard Professor Fei's voice, Fang Hanmin couldn't tell the truth, he could only perfunctory, "Professor Fei, although the overall technical strength of our unit is relatively weak, it is not nothing, and we have solved the problem of lack of talents by gathering the technical elites of the whole factory to do the development of generic drugs." ”

Lao Fei was noncommittal about this explanation, "Concentrate the technical elite of the whole plant? That might be the way to go. ”