"Analyze the quality of the current yeast."

[64% of good yeasts, 31% of poor quality yeasts, and 5% of harmful yeasts]

Chen Cheng was shocked, and at the same time found the problem.

"After several generations of yeast in this variety, the number of mutations is too large, which affects the taste of the beer." Chen Cheng took the lead in coming to this conclusion.

Anyone who has studied biology in middle school knows that sexual reproduction is more likely to undergo genetic changes than asexual reproduction.

Asexual reproduction, through mitosis or mitosis, can be understood as a copy of the genes of the previous generation, retaining all the characteristics of the DNA of the previous generation to the greatest extent, and the possibility of variation is very small.

If something goes wrong while DNA is being replicated, it's called a genetic mutation.

Sexual reproduction involves the process of combining the germ cells of the sexes, the process of DNA division and recombination, and this way of genetic recombination itself is the process of recombination of genes of the father and mother, and the genes of the offspring will naturally change.

In the process of producing beer, in order to ensure the stable taste and quality of beer, it is necessary to have as stable yeast genes as possible.

Therefore, sexual reproduction of yeast should be avoided as much as possible.

The four reproduction modes of yeast, budding, fission, and bud fissure, all belong to asexual reproduction, and only spores belong to sexual reproduction.

Therefore, Chen Cheng thinks that the problem must lie in the spore reproduction of yeast.

100% of the original selected maternal yeasts have more than 30% of inferior yeasts after several generations of reproduction.

What exactly causes it?

Spore proliferation of yeast occurs only in the presence of yeast malnutrition.

During the entire simulation process, the supercomputer uses the most standard air and temperature control, and the computer simulation is unlikely to have mechanical failures.

Why is this happening?

Chen Cheng clicked on the simulation process of the supercomputer and played it again.

This time, he used a special reagent to mark the yeast, and if it showed spore proliferation, Chen Cheng would obviously observe it.

Sure enough, as the yeast continues to multiply, the number of yeast produced by the proliferation of spores is increasing.

"Stop!" Chen Cheng shouted.

From the simulated virtual 3D image, he picked out a yeast with a precursor to spore proliferation, then zoomed in and took a closer look.

This yeast is noticeably smaller, and the other structures inside the cells appear weaker.

In short, it's the feeling of sickness.

"Is this considered malnutrition?"

Chen Cheng was puzzled and played back the simulation process and slowed down the playback speed.

Then he discovered that the source of the malnourished yeast was spore reproduction.

"That's weird."

Chen Cheng zoomed in on the observation window and continued to play it backwards.

Soon, he found the reason.

After the spores of the first two yeasts begin to multiply, their offspring show individual characteristics in addition to malnutrition.

Then these malnourished yeasts begin to multiply the spores on a large scale, more and more.

And he noticed that at this time, all the data in the entire malt solution were normal.

In other words, it is not environmental factors that cause their malnutrition, but their own genes.

Why is this happening?

Confused, Chen Cheng singled out a malnourished yeast cell, and then called up its genetic information to compare it with normal yeast genes.

The system quickly identified the two different gene segments, which affect the nutrient absorption of yeasts.

The conclusion is obvious.

In the process of sexual reproduction of spores, yeast is prone to the expression of recessive dystrophic genes due to the genetic recombination of the two.

"This..."

"Then it's just that they don't have sex anymore?"

Chen Cheng felt that it was a little inauthentic, the two small cells of the family loved each other, but he could only cut off their 'love'.

Thankfully, they're just emotionless, single-celled organisms.

Chen Cheng thought comfortingly.

Now there are two squares in front of Chen Cheng.

One is to edit the genes of this variety of yeast and completely remove its recessive genes for malnutrition.

In this way, even if it reproduces spores during reproduction, there will be no malnourished offspring.

The second is to improve the genes of yeast and completely make it lose the reproduction mode of spore multiplication. Anyway, this method is also genetically controlled, and it is easy and simple to delete directly.

As long as it cannot reproduce sexually, it is even less likely to produce malnourished offspring.

This is called eternal repercussions.

Chen Cheng did not blindly choose a method, but directly let the supercomputer start the simulation, and use the simulation results to determine the technical route.

Soon, the results of the two squares came out.

[Fang Eucalyptus, elimination of dystrophic gene expression: after ten generations of reproduction, the content of good quality yeast accounts for 78%, bad quality yeast accounts for 20%, and inactivated yeast accounts for 2%]

【Eucalyptus 2, elimination of yeast spore proliferation gene expression: after ten generations of propagation, the content of high-quality yeast accounts for 89%, the proportion of bad yeast accounts for 9%, and the proportion of inactivation accounts for 2%】

You can see at a glance which is better and which is worse.

But Chen Cheng needs to understand the reasons for the differences.

"Why do so many bad yeasts still appear after the malnutrition gene expression is removed?"

[In sexual reproduction, the offspring exhibit the expression of other undesirable traits other than malnutrition]

Chen Cheng suddenly realized.

Just like he removed the genes from the human gene that are prone to cancer, but that doesn't mean that the offspring won't suffer from other diseases.

In this way, it is most effective to directly cut off their sexual reproduction.

I can only say to the yeasts: sexual reproduction is forbidden.

Chen Cheng immediately took action to remove the spore proliferation gene of this yeast variety.

After completing the genetic modification, Chen Cheng asked the supercomputer to start simulating reproduction and iterating the most stable and high-performing yeast.

Finally, two minutes later, the supercomputer iterated on the optimized yeast DNA.

"Again simulating the taste quality of beer."

【Okay】

Another half minute passed.

[The taste quality has been increased by 57%, surpassing the taste of most low-end beers in China and reaching the taste of high-end beers]

Looking at this conclusion of the system, Chen Cheng smashed his mouth.

However, the simulations in the system are all virtual, and he will not be able to taste the taste of beer produced by the newly genetically modified yeast.

Now that the results are out, Chen Cheng doesn't stop, and immediately transmits its data into the life simulator.

Looking at the gradually multiplying yeast flora in the petri dish on the middle tray, Chen Cheng finally breathed a sigh of relief.

Small kiosk

After more than ten minutes, Chen Cheng extracted a small bag of yeast flora into reality.

Of course, the next thing is to make more with the Life Replica Machine.

It doesn't take too much, and they can quickly breed a lot of offspring when they are sent to the brewery anyway.

And they are also genetically stable.