第二百一十九章 再秀数据分析
Li Mu's question made everyone present stunned.
What do you mean?
Aren't the components they measured complete enough?
What really works is the other ingredient hidden inside?
They couldn't help but wonder.
"Boss, you...... Why? Kingsley Weir wondered.
"You'll start by answering if you've found all the ingredients." Li Mu was not in a hurry to explain.
Kingsley Weil thought for a moment, then said, "If only the ingredients that have not yet been determined...... There may indeed be some ingredients that have not yet been fully determined, after all, I believe that the boss also knows that for this kind of thing extracted from nature, there will always be some natural ingredients that we cannot fully discover, especially if its content is too small. ”
Li Mu nodded slightly, and said directly: "So, the next task is to find this part of the trace components that have not been discovered." ”
"And I can be sure that what we're looking for now is in these unknown ingredients."
As he spoke, Li Mu found the scratch paper from the side, and then wrote several sets of experimental marks on it, and after writing it, he handed it directly to Kingsley Weil.
"Just repeat these sets of experiments to determine the composition of the liquid medicine, if my analysis is correct, in these groups of experiments, the content of this unknown ingredient is relatively higher, it should be easier to find."
Kingsley Weil hurriedly took the piece of paper, then looked at it for a long time, and finally asked cautiously: "Among the groups of experiments you wrote, I found that two of them did not show good results, and even did not reach the average level, are you sure that the content of the unknown ingredient in the liquid medicine of these two groups of experiments is higher?" ”
Isn't it true that the better the effect, the more ingredients there are?
At least in this small amount, Kingsley Weil is very clear about this.
However, Li Mu just shook his head and said, "If you study traditional Chinese medicine, you should also know that there is such a thing as medicinal properties, and different combinations of drugs will also produce different effects. ”
"Of course, this is just the experience of traditional Chinese medicine, but if it is reflected in chemistry, it is that different ingredients will have an inhibitory effect on each other."
"It's like a catalyst, and it's an inhibitor."
"You know what I mean, right?"
"Oh, maybe it will help you find that unknown ingredient......"
After thinking about it, Li Mu took the piece of paper from Kingsley Weil again, and then wrote a chemical formula on it again.
【C9H7NO2NH3……】
Then, based on this chemical formula, he drew its molecular structure.
In organic chemistry, the chemical formula of organic molecules may be the same, but once the structure is different, the effect will be completely different.
就像那句话一样,结构决定功能。
"Basically, if I'm not mistaken, it's this thing that affects the display of the effect of that unknown ingredient."
Seeing this ingredient, Kingsley Welton was shocked.
"It's ...... 8-Hydroxy-2-aminoquinoline? ”
Because he also noticed the abnormal behavior of this ingredient in his experiments, sometimes with and without it, and it seemed to be irregular.
At first, Kingsley Weil thought that it was the effect of this thing, but after experiments, this thing was not useful at all, and even seemed to affect the effect of thrombolysis.
But now that Li Mu put it up separately and explained that it might be the "culprit" who suppressed the effect of the unknown ingredient, he immediately realized this possibility!
His face was filled with deep surprise.
Of course, all around, his former students were also full of surprise written on their faces.
Under Li Mu's few words, they all thought of this as if they had been empowered.
Looking at the molecular structure diagram drawn on the piece of paper in his hand, Kingsley Weil finally determined that this was the key to their ultimate success!
深呼吸了一口气,他看向李牧:“这也是您从数据分析中发现的吗? ”
Li Mu nodded slightly.
"This ...... Can I ask how that was done? Kingsley Weil said with some embarrassment, "I really want to learn." ”
Li Mu's scientific and systematic analysis method is much superior to his way of looking at a large number of experimental data and relying on intuition to find the outstanding points!
With intuitive searching, sometimes you can only catch the blind, but Li Mu's analysis can find clues from the clues!
For Kingsley Weir, this method is simply too greedy.
But Li Mu's eyebrows were raised, and he asked, "Are you sure you want to learn it?" ”
"I'm sure!" Kingsley Weil nodded repeatedly.
Of course, the assistants around him also nodded their heads one after another.
Just kidding, they were stunned for several days in the face of that large amount of data, but as soon as Li Mu got started, it didn't even take long, and he didn't even calculate it, and he discovered something they hadn't found before.
This is also Thai pants spicy, right?
Seeing their expectant looks, Li Mu smiled, and finally said, "Okay, then I'll show you a demonstration." ”
Naturally, there was no blackboard for them to use in the GMP laboratory, so Li Mu directly took the paper and pen and performed it on the table.
Kingsley Weil and the others gathered around him and watched.
"It might be a little hard, so don't be in too much of a hurry."
Before starting to write, Li Mu also made a special reminder.
Kingsley Weil said with a good feeling about himself: "It's not particularly difficult, anyway, I've studied for a while in the past few days, so I should be able to understand it...... I was still able to get an A+ in my math class when I was an undergraduate. ”
For his words, Li Mu just smiled without commenting.
"Really? That's good. ”
Then, his demo began.
再然后,实验室中就多出了数脸懵逼。
Kingsley Weil looked silently at the mathematical formulas written by Li Mu.
“……?”
Obviously, everyone has learned general knowledge, why can Li Mu use it so well?
Since then, he has deeply understood one thing, that is, when Li Mu said that it was a little difficult, they had to pay attention, because for them, it would be very, very difficult.
……
In the end, Li Mu gave them a complete demonstration of his own analysis process.
Despite Kingsley Vale, they all ended up watching it with a confused face.
They finally understood why in the past few months, the entire biomedical community has been discussing Li Mu's data analysis methods very hotly, but not many people have made any achievements.
Let's start with the math!
"Well, I thought I had researched something, but now it looks ......"
Kingsley Weil sighed helplessly.
It's not a grade at all.
Li Mu smiled.
In fact, he hasn't said that this seemingly complicated process is very simple for him.
Just like at the beginning, he just had to go through the data with the computer in his mind, and soon he would get the results.
Of course, there is no need to say such words, so as not to affect Kingsley Weir's mentality.
Putting away the pen in his hand, he got up and said, "I will put this analysis process here, you can study it yourself." ”
“接下来,就要看你们的实验了。”
Kingsley Weil recovered from the shock just now, then stood still, and said, "On this point, you can rest assured, since we have such a detailed analysis, we will definitely succeed." ”
"You say yes?"
He looked at his former students, now his assistants, and asked with a smile.
"Yes!"
The students all nodded.
The biggest fear for their experiments is not knowing what to do next.
Experiments can only be repeated in an attempt to find undetected phenomena.
This is also one of the reasons why a large number of biological papers that appeared in Science, Nature, and Cell could not be reproduced by others.
Excluding the possibility of data falsification, the only possibility left is that they themselves have repeated the experiment many times when they are doing it, and others want to reproduce it, which of course becomes more difficult.
And now, with Li Mu's analysis to help them lock in the target and scope, it will naturally be of great help to their research.
This is also why the biology community has always been so sought after for Li Mu's data analysis methods.
So, then, their experiment officially began.
首先就是重新配置李牧标出来的那几组实验中所用到的药液,比如要取多少克的地黄汁液,再或者是已经煎熬过的提取物,然后进行配比。
It looks like they're alchemizing - in fact, they're doing much like alchemy.
The unknown ingredient is the gold they want to refine.
For the experiment of researching drugs, the most important thing is to find the ingredients that are effective for the symptoms, and then extract the active ingredients and mix them with other auxiliary ingredients to make drugs.
So generally speaking, a medicine may weigh 0.5 grams, but what really plays a role is often only a few tenths of a milligram of the main ingredient, and the remaining components are generally thinners, binders, colorants, etc., and then flavoring agents, that is, ingredients that make the original bitter medicine taste sweeter.
Of course, no matter what, those active ingredients are used to make money.
This experiment will probably take a long time, and it is normal for anyone who studies biology to live directly in the lab.
当然,作为老板的李牧,虽然也可以直接就离开实验室了,不过抱着对实验的一定兴趣,他还是留了下来,决定多看几天他们的实验。
And just like that, time passed quickly.
……
(End of chapter)