Chapter 224: The Surprise Effect of RSCA, an Important Drawback of PEFF
As Li Mu's mind moved, another real blood vessel model appeared in front of him, and then, his mind moved again, and a very serious thrombus appeared in the deep veins of the lower limbs of this real blood vessel flowing with blood.
Deep vein thrombosis in the lower extremities, once it falls off, will travel in the systemic veins, and eventually can easily lead to severe pulmonary embolism, in addition to causing a variety of diseases.
Therefore, this is also a very high-risk blood clot condition.
随后,模拟世界中,李牧的人出现在了这里面,他的手中也随之出现了一支注射器。
The drug in the syringe is the RSCA solution.
In the simulation of the real cosmic environment, no other experiments can be carried out as long as the subject of the experiment is determined.
For example, now that he has identified the topic of hydrodynamic analysis of blood vessels, he can no longer study how to synthesize new drugs.
Still, he was able to test the effects of various thrombolytic drugs in this experiment.
As long as he knows the chemical composition of these thrombolytic drugs.
It's a little hole that can be exploited.
As his mind moved again, the simulated body in front of him reappeared from the transparent state, and then found the injection area of the buttocks for subcutaneous injection.
After the injection was completed, Li Mu began to speed up the time speed of the simulated world, and at the same time paid close attention to the blood clot of the simulated person.
Just a few seconds passed, and ten minutes later, Li Mu observed that the thrombosis in the deep veins of the lower limbs gradually began to disappear.
Plasminogen is activated, allowing the fibrin in the thrombus to be quickly dissolved, even if it is not dissolved for the time being, after the attachment of the RSCA component, the fibrin becomes smoother and no longer easily forms blood clots with platelets.
The blood vessels are reopened.
李牧露出了赞赏的目光。
This thrombolytic effect is indeed very good.
At least it's much better than the 123rd generation of thrombolytic drugs he used before.
Prior to this, he had tested the effects of previous generations of thrombolytic drugs.
In terms of current effects, these generations of thrombolytic drugs are not as good as their RSCA.
Of course, the main thing is that RSCA can be applied to many different thrombotic symptoms.
不像是其他的几种溶栓药物都有专门针对的血栓症状,就比如阿替普酶就主要用于治疗急性心肌梗死和肺栓塞。
After observing for a while, Li Mu was quite pleasantly surprised to find a point.
RSCA has a very unique thrombolytic specificity, so it rarely causes additional bleeding symptoms.
Other thrombolytic drugs will increase the activity level of plasmin in the body, which will cause plasmin to dissolve fibrin other than blood clots, such as fibrin in blood vessel wall cells, resulting in blood vessel rupture and bleeding symptoms.
这属于溶栓过程中的常见并发症,一旦严重点,比如引起了脑出血,就反倒有可能导致患者死亡。
Now, according to Li Mu's simulation, the specific recognition of RSCA can almost make it only recognize plasminogen in the thrombus, so that it can be excited as plasmin without dissolving the cell wall.
This means that even those with a bleeding constitution will be able to use RSCA!
Ordinary patients don't have to worry about the bleeding complications that may occur after using RSCA!
He opened his eyes and looked at Kingsley Weil next to him.
"Well done!"
Hearing the boss's encouragement, Kingsley Weil, who was still a little puzzled about why Li Mu suddenly closed his eyes just now, had a smile on his face.
"Of course! As I said, you won't regret it, and that's my promise. ”
Li Mu smiled, then lowered his head and flipped through the report in his hand again, which did not explain that RSCA also had the effect of avoiding bleeding complications.
He said, "It seems that you don't know that RSCA has another very important function. ”
Kingsley Weil was stunned, "What effect?" ”
Li Mu said this role.
Kingsley Welton was stunned, how did Li Mu do it, read the report and be able to find this?
Puzzled, he asked, "How do you know this?" ”
Li Mu smiled, of course, he couldn't say the actual reason, but after observing the "result" in the computer in his mind, at this time, he could analyze such a result through data analysis.
The method is simple, it only needs to analyze the fibrinolytic level of the blood in the data.
So he brought a pen and paper from the side, and after some simple calculations, he came up with a clear result.
“…… Therefore, RSCA has a more unique specificity and can avoid missolubilization of fibrin. ”
Seeing the results of Li Mu's analysis, Kingsley Weir's eyes widened suddenly, and his face was full of excitement: "What do you mean...... 您的意思是……我们还顺带着解决了所有溶栓药物的并发症?! ”
"Yes." Li Mu nodded.
"Generous Crab!"
Kingsley Welton jumped up and down the room in excitement.
He knew all too well what it meant about that.
这也就意味着,原本因为体内有出血症状,或者是易出血体质,而只能采取外科手术除栓的血栓患者,现在都可以使用他们的RSCA了!
In this way, they invisibly expand the possible patient customer base.
Thinking of this, Kingsley Weil couldn't stop being happy.
Hey, what if that guy Skarna Slavi is ahead?
After all, it's just an ordinary fourth-generation thrombolytic drug, how can it compare to their RSCA?
忽然间,想到了斯卡纳·斯拉维他们的第4代溶栓药物后,金丝利·韦尔忽然又安静了下来,思考片刻后,对李牧说道:“老板,你能不能够通过数据分析,分析出斯拉维那个家伙,他们的溶栓药物有没有什么副作用? ”
"Do you have their experimental data?"
Li Mu glanced at Kingsley Weir.
"Uh...... This is not specific, but they sent the paper to Cell, can you see if you can analyze some problems? ”
As he spoke, Kingsley Weil brought a magazine from the side, which was the latest issue of Cell.
Soon he turned to the paper published by Skarna Slavy's team.
It was about the introduction of their 4th generation thrombolytic drug, PEFF.
The active ingredient of any drug is disclosed, as long as it is patented, and as for clinical practice, it generally does not conflict with patents, so any new drug will first apply for a patent and then conduct clinical trials.
Only the specific preparation process and the proportion of excipients will not be disclosed.
Then, Li Mu took it over and began to look at it.
Soon he learned the specific composition of this PEFF from the paper.
Raising his eyebrows, for him, as long as he knows the specific ingredients, he can simulate them in his mental calculator.
Then, the mental calculator is able to deduce the actual effect.
So, he closed his eyes again.
And Kingsley Weil, who was next to him, saw Li Mu close his eyes, and immediately thought that he had probably started mental arithmetic again.
For a moment, he shouted in his heart: "Boss, use your invincible analytical ability to analyze the shortcomings of this PEFF!" ”
At the same time, Li Mu has entered the simulation and began to simulate the effect of PEFF.
With the entry of PEFF injection, after the acceleration of time, after about 20 minutes have actually passed, the blood clot in the simulated patient's body began to show signs of dissolution, of course, in terms of speed, it is not as fast as RSCA.
"However, compared to the third-generation thrombolytic drugs, it is still quite good."
Li Mu squinted his eyes and thought slightly in his heart.
PEFF can be taken so seriously by Pfizer, and it is naturally not a simple drug.
It's just that as time passed, he suddenly noticed something different.
"Huh? There seems to be something wrong with platelets......"
“血小板的活性有一定的异常增高的,虽然不算太高,却凭白提高了血栓复发的风险性……”
Li Mu's eyes suddenly narrowed.
His mind was reminded of the data from the paper.
It seems true that there is a certain increase in the viscosity coefficient of the blood, but it is not more pronounced.
Of course, even if it is not obvious, it cannot be underestimated, because the thrombus is formed little by little.
I just don't know if this happened on purpose, or accidentally.
If it's intentional, it's terrible.
Blood clots recur, and their drugs can be sold repeatedly.
It's scary, of course, but it's also scary that they are able to control the properties of the drug.
If it's accidental......
Li Mu opened his eyes.
金斯利·韦尔便一脸期待地看着他:“老板,怎么样? ”
Li Mu said: "It's hard to say. ”
Kingsley Weil was stunned: "Why is it so hard to say?" ”
李牧将血液粘滞度提高的事情告诉了金斯利·韦尔:“我怀疑,这可能是血小板活化程度变高了的原因造成的。 ”
"In other words, after using their drugs, there is a high probability that blood clots will recur repeatedly."
Kingsley Welton was stunned.
"What?! And this kind of thing? ”
(End of chapter)