"No, it's not. Shen Ke shook his head.

He has looked at countless virus data in the past two days, and it is certain that Yuan Zirui's words are not true, although MERS-CoV comes from dromedary camels.

However, there is an essential difference between viruses in animals and viruses in humans.

This difference is known in virology as population isolation.

Without this protection mechanism, so many viruses in wild animals would have been transmitted to humans long ago.

The reason why various coronaviruses can be introduced from animals to humans is only because of one reason, breaking through the population isolation.

And to break through the population isolation, its virus must change.

This change is not necessarily a change in the structure of the protein, not necessarily a change in the gene sequence chain.

So where exactly has changed?

"Induce enzymes. ”

Shen Ke, who had epiphany skills, frowned and thought for a while, and this term suddenly popped up in his mind.

"That's right, it's inducing enzymes. ”

The virus itself does not contain enzymes, but in order for it to replicate and spread, it needs to use parasite-inducing enzymes to allow it to parasitize and target replication.

MERS-CoV can be present in dromedary camels because of their own inducible enzymes.

Originally, there was no specific inducer enzyme in the human body, but I don't know what happened, MERS-CoV underwent some kind of mutation, which caused a change in the inducer enzyme information factor it received.

The new proprietary inducible enzyme exists in the human body, so MERS-CoV can survive in the human body.

Now it is only necessary to identify this inducible enzyme to determine the targeting of MERS-CoV.

I am afraid that there are also virology experts who think of this, including Dr. Yu.

But...... These virology experts would never have imagined that Shen Ke had built a method in his mind at this time to find the method of inducing enzymes in dromedary camels.

They can think of finding a target by inducing enzymes, and the difficulty is how to determine the inducible enzymes in dromedary camels.

The method that Shen Ke came up with was extremely simple, that is, to conduct a double virus interference tracking test through another virus and label the induced enzyme.

This virus is the 229E virus.

Since 229E in humans can bind to MERS-CoV, what about dromedary camels?

The reason why Dr. Yu and they definitely couldn't think of this is that they can only virology, and only Shen Ke has read all the biology books in the past few days.

Only then will you know how the active enzymes in the organism induce the work of antibodies.

This falls under the category of biology.

Maybe Dr. Yu will be able to think of it in a few years, but now that it has just been determined that 229E can bind to MERS-CoV, in a hurry, where can Dr. Yu think of a biological method that he is not good at?

In this way, there are really too few general practitioners in China.

Whether it is medicine or other scientific and technological fields, it is really not that simple, and it requires the cooperation of many types of science.

With the development of the times, general practice will be the general trend in any field.

"Zirui. Does the laboratory keep the virus serum stock solution of dromedary?" Shen Ke asked Yuan Zirui.

"Yes. Yuan Zirui nodded immediately.

"Take it out, take another 229E virus serum, and let's do another animal serum virus infection test. ”

Although Yuan Zirui and Pan Xueyi didn't know what Shen Ke was going to do, they still actively cooperated, Yuan Zirui went to get serum, and Pan Xueyi checked the test equipment.

At this time, it was already three o'clock in the evening, and the entire Southeast University was quiet, only three people in the laboratory building were still busy nervously.

"This stock solution ......"

Shen Ke was stunned when he saw the dromedary serum puree that Yuan Zirui took out.

"What's wrong?, isn't this serum right?" Yuan Zirui immediately asked.

"It's not. ”

Shen Ke shook his head, but he had already scolded in his heart.

"Nima's, wouldn't it be better to take out this thing earlier?"

Before the test was done, Shen Ke only looked at the serum stock solution and knew that he had guessed correctly.

Shen Ke now has the god-level skill of identifying medicinal materials, which is equivalent to a medical genius who has been immersed in medicinal materials all his life. I have seen countless drugs and know the medicinal properties of countless drugs.

Whether it is traditional Chinese medicine or Western medicine, as long as it is a medicine that can cure diseases, Shen Ke can basically understand it.

The serum in front of him, judging from the color, Shen Ke knew that it was infected with a virus, and the binding protein in it had been damaged, causing the color to darken.

But this serum, Shen Ke knew that it could be injected into the body of patients infected with 229E, because the serum contained the MERS-CoV virus, which would bind to the 229E virus.

Then, due to the difference in its inducing enzymes, the combination of the two will cause MERS-CoV to lose its replication function and be inactivated even with 229E.

This is the basic principle of animal serum treatment, because the difference in inducing enzymes allows both viruses to die in the human body.

This may be the legendary fight against poison with poison.

"Damn, take out this thing early, why do I have to toss it for three days?"

Shen Ke almost wanted to slap himself.

However, it is still only an inference, although the knowledge of medicinal materials in my mind is equivalent to the experience of countless medical experts, but the experiment is rigorous and must be conclusive.

The trio began to test animals for serum infection.

An hour later, the results were in. MERS-CoV binds to 229E, but all become inactive.

Then an in vitro serum infection test was done and the same result was obtained again.

Yuan Zirui and Pan Xueyi were so excited that their hearts were about to jump out.

But they know that there is still the most critical step of the test, and only when the last step is successful can the test be considered a real success.

The two suppressed their ecstasy, and in the middle of the night, they were full of energy, and they paid 120,000 attention to the third test.

"Dual Virus Interference Tracking Trial. ”

Pan Xueyi nervously watched Shen Ke operate the experimental equipment, constantly observing the state of the virus in the high-powered microscope.

Yuan Zirui here, his eyes stared at the computer screen without blinking, and he didn't let go of every position on the screen.

Suddenly, a red marker appeared on the screen.

Yuan Zirui felt as if his soul was about to go out of his body, his trembling hands, holding the mouse tightly, clicking, and frozen.

Then, Yuan Zirui let out a cry that shook through the experimental building.

"It worked, the mark was successful. ”

Yuan Zirui suddenly collapsed from his chair.

Pan Xueyi ran over for the first time, looked at the computer screen, looked at the red spot on the screen, was stunned for a few seconds, and immediately cried with joy.

"We succeeded, we succeeded. ”

Two friends who have been fighting side by side for four years hugged each other tightly.

Shen Ke raised his head from the microscope and looked at the two people who were hugging, with a knowing smile on his face.

I don't know why, at this moment, Shen Ke didn't think of his company for the first time, seeing Yuan Zirui and Pan Xueyi crying, Shen Ke was just inexplicably moved.

Perhaps this is the most real side of scientific research workers who are really struggling on the front line.

How many such silent givers in the country, how happy they are when they succeed, they know how lonely they are when they fail.