Chapter 627: Active Compounds
After a day and a night of fierce battles, cheers rang out in the laboratory: "It's done!"
New compounds are born, and then various tests are carried out.
The chemical structure test data showed that this was an eight-membered heterocyclic compound.
"Director Shen, give this eight-element heterocyclic compound a name. Cao Fan, who has gradually grown up, said excitedly and expectantly.
Naming new compounds is a basic operation, and anyone in the lab is proficient in using more than three internationally accepted nomenclature conventions.
Some time ago, He Lin and Cao Fan made seven-membered heterocyclic compounds.
They use compounds a, b, c...... z to note these seven-membered heterocyclic compounds, and if the English letters are used up, continue to use the combination of English letters + Arabic numerals.
In this project, compounds below the eight-membered species do not deserve an official chemical name, as they are all process products.
Of course, these process products are also meaningful, without the process, how can the results be?
The new eight-membered heterocyclic compound is different, it is to be tested for activity. If the activity test passes, the next step is to synthesize the drug.
The patent medicine came out and passed several phases of clinical trials, then the project was successful.
If the LPJK1 project is successful, it will not only be a victory for drug synthesis, but also a victory for basic theoretical research.
The comprehensive victory of academic research combined with engineering application has brought about the victory of saving people's lives and building a seventh-level floating slaughter.
At such a meaningful moment, the naming of the first eight-membered heterocyclic compound, the masses unanimously suggested that Shen Qi should operate it.
"Then I'd be respectful and obey. Shen Qi folded his hands to express his gratitude, and he thanked everyone for their efforts.
There are several heterocyclic compound nomenclature principles in the world, and Shen Qi decided to adopt the Hanqi-Weidemann heterocyclic system nomenclature.
In this nomenclature system, the unsaturated ring ring with the maximum number of non-cumulative double bonds is generally named as a suffix, and the three-to-ten-yuan ring corresponds to the heavenly stem of A, B, C, D, penthexylheptaxin, and the ring that exceeds ten yuan is eleven and twelve......
Based on the nomenclature of the Hanqi-Weidemann heterocyclic system, Shen Qi quickly gave the name: "1,3,4-triazaxixin ring, hard work, do the activity test." ”
The daily life of a chemical dog is one experiment after another, one test after another.
Patriotic, dedicated, honest, friendly.
Since you have chosen this profession, let's be old in the wilderness.
Activity testing is the process of selecting specific cells as test cell lines, and then performing specific activity tests on the synthesized compounds.
If the activity test result is OK, then the active compound can enter the animal test stage.
If it is not OK, then the aforementioned "saving a life is better than building a seventh-level floating slaughter" is equivalent to blowing water.
The activity test of compound 1,3,4-triazaxictane ring is ongoing.
The experimenters brace themselves to the test.
"OK! Activity test OK!"
The good news is that the LPJK1 project finally has an active compound.
But one active compound is not enough, what if it does not pass animal testing?
So stock up on a few more active compounds.
For a drug project, small pharmaceutical companies outside usually prepare two or three active compounds, large pharmaceutical companies generally reserve more than 20, and pharmaceutical giants like GLK often prepare sixty or seventy active compounds.
Active compounds that have passed animal testing and are valuable in the market. If it passes the first phase of clinical trial, its value will continue to increase.
Most small pharmaceutical companies do not make new drugs, and they sell them to large pharmaceutical companies after obtaining the active compound, passing animal experiments or phase I clinical trials.
The second and third phases of clinical trials are too expensive, and small pharmaceutical companies can't afford to play at all.
The patent development rights of LPJK1 have been sold to OBEQI Pharmaceutical, which has a model of factory cooperation with laboratories.
Shen Qi's laboratory gave Obic Pharmaceutical, and Obic Pharmaceutical did anything.
"Continue to do active compounds, and make derivatives of 1,3,4-triazaoctyl rings. Shen Qi led everyone to continue to work hard, accumulate grain, and make more active compounds.
Monday.
The chemical laboratory of Shen Qi Scientific Research Center has reported another good news: "Success, success, 1,3,4-triazaxincyte derivatives 1 have been synthesized!"
"OK, OK, OK!The activity test results of 1,3,4-triazaxixin derivatives 1 are OK!"
Tuesday.
The chemistry laboratory of Shen Qi Scientific Research Center was excited: "It's done, it's done, the derivative 2 of 1,3,4-triazaxine ring has been synthesized!"
"No problem, no problem, no problem! The activity test results of 1,3,4-triazaxictane derivative 2 are no problem!"
Wednesday.
"Damn, failure, failure!"
Thursday.
"Awesome, awesome, awesome! The third derivative activity test is excellent!"
Friday, like Thursday, is omitted.
Working overtime on Saturday, the result was similar to Wednesday, failure.
I continued to work overtime on Sunday, and the results were as great as Friday, omitting the list.
Counting the 1,3,4-triazaxine ring, in one week, the chemical laboratory of Shen Qi Scientific Research Center made 6 active compounds that passed the activity test.
In other words, Shen Qi's group of people makes an active compound a day on average.
It's terrifying.
The horror continues.
Under the leadership of an award-winning and leading mathematician and physicist, the chemistry laboratory of Shen Qi Research Center produced 22 active compounds in one month.
Compared with the laboratories of large pharmaceutical companies, the efficiency and success rate of Shen Qi's laboratory are several times that of theirs.
The LPJK1 project has advanced to the current stage, and the degree of secrecy is very high.
During this sensitive period, Miss Lucy Walker of GLK visited Shen Qi on the grounds of academic exchange.
Shen Qi met Lucy because of the last visit to China by a British academic delegation.
The British academic delegation has long since returned to Britain, and Miss Lucy remains in China, where she is now the Head of Business at GLK China.
To put it simply, the last visit of the British academic delegation to China was a great success, and China and the UK reached a high degree of consensus on many academic research projects and engineering application projects, and will carry out specific cooperation in different fields in the future.
Shen Qi received the British delegation with a very friendly and professional professional quality, which was highly praised and deeply recognized by the British side, and the British side expressed its sincere gratitude to the Chinese Foreign Affairs Office and sincerely hoped that the Chinese academic delegation would visit the UK in the near future.
In view of Shen Qi's outstanding performance in the diplomatic field, the state has planned to arrange for Shen Qi to continue to receive the French academic delegation, the Swedish academic delegation, and the Japanese academic delegation.
Shen Qi received Miss Lucy, who came to visit her, in the central café, he looked at his watch and said, "Lucy, I only have ten minutes, you pick and choose the key points." ”
Lucy made a helpless, dissatisfied expression, and said in her heart, Professor Shen, you have changed.