As Lu Cheng continued to elaborate in depth, Lin You really began to look at Lu Cheng from the eyes of an important member of the team.

Whether it was the scientific research thinking shown in the department, the rigorous data processing ability, the solid foundation, or even the expressiveness in the surgery, Lin You was not able to pay so much attention to it.

It's not that people who can do surgery do research.

It's not that people with a solid foundation will study.

Research is a meticulous process, and even if it is sharpened into a needle with an iron rod, it is not excessive, or even more difficult.

With the improvement of human cognition, the essence of disease itself is also constantly deepening.

From the very beginning of the clinical manifestations, to the pathological patients.

and then to the pathogenesis, developmental mechanisms, and control pathways.

At the cellular level, what are the activities, aggregation, invasion and expansion capabilities of cells in the pathological state?

At the cellular level, however, it is still far from being able to understand the nature of disease.

Any drug has a mechanism of action.

This mechanism of action should be deeply excavated from the basic disciplines of physiology and biochemistry.

From the physiological level, the electrical activity of the cell membrane, its receptors, the transport mechanism of the spread of the disease itself, and so on.

After digging up the physiological level, it is not enough, but also from the various organs at the biochemical level.

For example, glucose metabolism, lipid metabolism......

At the metabolic level, is it enough?

No.

The level of metabolism is just a manifestation of genes.

In a pathological state, if you can't find the essence of the pathological changes, how do you use medicine?

Even if it is prevented with medication, it will regenerate, that is, there is no meaning of breaking the root.

Okay, then keep digging.

Let's not mention how many enzymes exist at the biochemical level and the mechanism by which these enzymes are produced.

It is the transport of the nature of pathological changes, and it requires gene mapping, mRNA transcription, tRNA transport, and a lot of LincRNA modification of mRNA and tRNA by genes, that is, DNA fragments.

The things involved in this are too deep and too broad.

So deep that probably all the top experts and professors in the world can't really become ignorant after spending their entire lives in the lab.

Yes, it's not ignorance.

It sounds pathetic, but that's the truth.

After these mechanisms are understood, the search for the corresponding drug begins.

The corresponding drug, the target of action, and the mechanism of action will have an impact on normal cells. It is best to find targets where pathological cells are present but normal cells are not.

This will take many more years.

Moreover, the drug has a systemic effect, so it cannot cause side effects on the normal cells of other tissues.

After the cell experiment, then the animal experiment.

After the animal experiments have been validated, they will go through multiple rounds of multi-center clinical trials.

Ensure that the drug does not have side effects and effects on a large scale, or even the world, due to racial and individual differences.

After this, the drug can be born and come to the clinic.

The cost of this is incalculable.

The cost of time is mostly from twenty or thirty years......

Lin You also knows that it is still too far to consider these overall situations at present.

At least for now, Lu Cheng has a deep understanding of the mechanism of bone tumors themselves.

Of course, he can't compare to him, who has specialized in research for five or six years and has made some achievements, but he can understand the various pathogenesis of osteosarcoma so clearly, and ordinary doctors can't compare to him.

Could it be that mathematics is good at doing research, and when it comes to research, it has such a big advantage?

Lin You couldn't answer this question.

He didn't interrupt Lu Cheng either.

Finally, Lu Cheng stopped.

Lin You smiled with relief and said, "Master, I thought you didn't have time to prepare, but I didn't expect that you had already prepared so well when you came to me. This is the best gift you have ever given me, Master. ”

"With that in mind, you can be directly involved in any of our team's meetings in the future, and I'll focus on your points. ”

"With such an in-depth understanding, you will not be short of articles. ”

"So, in the near future, well, in two months, you should try to write a review and practice with Meta. ”

"Basic research-based article articles also need to have a certain foundation in writing papers, otherwise it will be extremely difficult for you to write directly. ”

"Are you confident?" Lin You saw that Lu Cheng had such a deep foundation, so he directly assigned the task.

Experiments don't need to be done every day, so Lu Cheng still has some free time.

It's a waste of time to just read literature, especially since Lu Cheng already has such a deep knowledge of literature, if he doesn't take advantage of this time to make a little article, it is really a waste of time.

However, Lin You also seemed to know that Lu Cheng cared about clinical practice, so he said: "Because only a large number of high-quality articles are used as a basis, you can apply for early graduation." ”

"However, you are a master, and this training is troublesome. ”

"Of course, there are special approvals. You should understand what I mean. But the road has to be taken one step at a time. ”

Lin You was tempted again.

Of course Lu Cheng understands.

What does early graduation mean?

What he wants is that Lin You doesn't get stuck here.

Then, if other people don't get stuck, the leaders of the hospital don't get stuck, and people from the outside world don't get stuck, and they don't even question it.

Then you have to make something.

For example, you publish a top-notch article in top magazines like Lancet, New England, or Cancer.

Then, it is enough to prove that your research level exceeds that of most current doctoral students and even graduate students and doctoral supervisors, and can be close to the level of academicians.

If you can do three or five articles, then I'm sorry, what level of restrictions don't exist here, you don't go to clinical first, get the title and then slowly study in clinical practice, and no one will say anything about you.

After all, these articles of yours can bring great reputation to your school and your hospital.

People can't do it, you can do it, they can only blame shut!

There are no exceptions.

Of course, just a scientific research boss, of course, can't do it, that's a careless human life.

Is Lu Cheng a simple scientific research worker?

Of course not, from the solid hands-on skills he showed during this time, he is not a doctor who can only research, not see patients.

This kind of person, you don't have to be born, as long as it is a school, or even some top teaching hospitals abroad, you are also happy to send an offer and welcome Lu Cheng to go.

"I'll try. Lu Cheng didn't say it all, although he had issued a lot of SCI in his previous life, but after all, the field was different.

"Well, then do you have a direction? Judging by the confidence in your words this time, it seems that you already have eyebrows?" Lin You asked.

"Well, I decided that the first article would be a water first, and a four- or five-point review would be fine. It's the equivalent of being a stepping stone. So, look for an article that I wrote about meta many years ago, but no one paid attention to it for many years. It's not hard. ”

Lu Cheng said confidently: "And SCI articles, as long as they are written, they can generally be voted out slowly, and I am not in a hurry." ”

"I happened to have read an article about knee replacement approaches the other day. ”

"There are a lot of meta-analyses for this kind of article, but so far, there is no meta-analysis on meta-analysis, so I am going to write one from this level. Lu Cheng replied casually.

Lin You immediately frowned, sure enough, Lu Cheng, who was good at data processing, would give him a problem.

Lin You was a little embarrassed, and said tremblingly: "That." ”

"Xiaocheng, why don't we make something simple, right? If you want to write a meta, Master can't give you any help. ”

Lin You, I really won't.

Writing this kind of article requires strong data processing ability, and simple meta-analysis and Reviewman software certainly cannot meet it.

"It's okay, Master, I'll try first. When the time comes, you can help me with the text and data processing, I can just do it myself. ”

Then Lu Cheng jokingly said: "Anyway, even if I make a mistake, no judge can see it." ”

This is also true.

Unless the editor of a medical journal is looking for a math major to review the manuscript, what he is going to do is generally not understood by the judges.

The reason why Lu Cheng wanted to do this was, of course, Lin You's words of graduating early, which attracted him.

So, if you want to do it, of course you have to make a big one, and make a small fuss, Master, just like you said, what are we doing with that thing?