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In fact, when he came to Naya's laboratory, Bai Ye's focus was not to study the modeling of renal hypertension, but to study the model of essential hypertension through the process of renal hypertension modeling.

Riesakel's model of essential hypertension is a product of genetic engineering, and essential hypertension is achieved by modifying a certain gene sequence.

However, you can't become a big fat man in one bite, you must have a solid and stable foundation, just like your high-level martial arts cheats, but you don't have an introductory mental method.

Moreover, modeling is only a method, and what is really Bai Ye hopes to improve his genetic engineering level through the process of using genetic engineering modeling.

The level of genetic engineering is high, and it is definitely open in the current environment!

The key is that this kind of modeling can also allow him to complete Zhang Hanlin's serial tasks, which is also a top priority.

Keao's mission has always been one of Bai Ye's minds, if you want to prove the instability of KM mice under drugs, and change the unstable sequence of mice to discover new products, this must be based on a high-level level of genetic engineering.

Bai Ye's joining made Dong Cunguang even more ambitious and high-spirited, and every day the two of them held a few thick books related to genetics to discuss, or they were to take the embryonic cells of mice to do research.

I have to say that Naya attaches great importance to scientific research, millions of equipment can be bought, and Dong Cunguang's laboratory is equipped with all kinds of modern scientific research equipment.

Nucleic acid molecular hybridization technology, accounting gel electrophoresis technology, DNA sequence analysis technology, gene site-directed mutagenesis technology, polymerase coupling reaction technology......

These books and materials filled Dong Cunguang's laboratory.

Bai Ye's learning is selective, because when he first acquired genetic engineering skills, conditions were required for activation.

[Genetic Engineering Lv3, Requirements: Basic Skills: Genetic Diseases: Lv3, Molecular Biology: Lv3, Cell Biology: Lv3.] 】

Dong Cunguang was originally engaged in bioengineering, and he was very accomplished in memory engineering, and under his leadership, Bai Ye's progress was very fast.

In a few days, Bai Ye's genetic diseases, molecular biology, and cell biology all reached lv3.

And Bai Ye also heard a ding:

[Scientific Research Skill: Genetic Engineering Activation, Current Level Lv3: 3900/10000.] 】

Bai Ye understood that this extra 3900 experience was the result of his study and experiments these days.

In the next few days, Dong Cunguang received an expatriate notice that he was going out to attend an academic forum, and Bai Ye was left alone in the laboratory.

However, under the leadership of Dong Cunguang, Bai Ye has also learned the use and operation skills of these instruments.

After this period of study, Bai Ye wanted to try his hand at the research of a new type of essential hypertension mouse.

It is recorded in the "Mouse Raising Experience" that it is necessary to compare the molecular sequence of ordinary rats with the same breed of hypertensive mice, and then obtain matching nucleic acids, and then use the shotgun method at the mutation point, which is carried out under an ultramicroscope, and the most important thing is that there is a suitable hypertensive mouse model.

And Dong Cunguang has been studying the SHR gene sequence for a long time, and on his basis, Bai Ye feels that the time is ripe.

Bai Ye extracted the DNA sequence of the embryonic cells of ordinary SD rats, analyzed them in a DNA molecular sequence analyzer, and then separated them by electrophoresis to obtain nucleic acids.

However, shotgun replacement is not so simple, and many kinds of separation under the microscope are very problematic.

However, when Dong Cunguang came back, the progress of the research was much earlier, but not all recombinant DNA can survive, especially inbred mice like SHR, who already have essential hypertension and a variety of recessive genes, and it is not easy to form a stable nucleic acid sequence after combining with ordinary mice.

Bai Ye looked at the sequence diagram of the two sets of DNA and said, "Actually, we may have walked into a misunderstanding. ”

Dong Cunguang was stunned: "What do you mean?"

Bai Ye frowned and looked at the two sets of sequences: "Maybe we can change our thinking and improve SHR, instead of putting the SHR gene into other mice." ”

Dong Cunguang's eyes suddenly lit up: "You mean to use the stable nucleic acid structure of ordinary mice to make up for the genetic defects of SHR?"

………………

………………

Three days later, the two had cultivated a new batch of embryonic cells, waiting to be implanted into the female mother rat and waiting to hatch to see the results.

Waiting is the longest process, but Bai Ye's harvest is quite rich.

The most expensive member, your scientific research skill genetic engineering level has been increased to lv4. 】

After the level reached lv4, Bai Ye felt that many originally complex questions in his mind suddenly became clear, which was not only a level increase, but a kind of systematization and perfection of knowledge.

Bai Ye felt that the originally hazy and mysterious DNA sequence seemed to have a clue.

At this time, the new model rat needed to wait for the results, and Bai Ye didn't want to continue researching.

He has a more important thing, which is the study of the stability of the gene in KM mice.

With the foundation of this period of time, Bai Ye felt that he was full of confidence.

However, KM mice, as a mature and commonly used test mouse, want to deny its stability, which is obviously an unwise idea.

However, after Bai Ye consulted a large amount of data, he found that there were indeed some examples of experimental failures, and the reasons were unknown, but many of the animal experiments used in these experiments were KM mice.

In fact, the reason why mice are used as human drugs in experimental animals is because the researchers analyzed the genome sequence of 96% of mice, and 99% of the genes can find homology in the human genome sequence, which confirms that mice and humans have a high degree of homology at the genetic level.

But that doesn't mean that mice and humans are genetically similar.

For example:

A：1，2，3，4，5，6，7，8。

B：1.2.3.4.5.6.7.9.10.11.12.13.14.15.16，17，18，19，20，21，22，23，24，25……

90% of the numbers in the A series can be found in the B series, and you dare to say that the two series are very similar?

In fact, the relationship between these two series is similar to the relationship between the mouse genome and the human genome.

99% of mouse genes can find homogenic sequences in humans, but human genomes cannot be found in mice.

What Bai Ye wants to do is to prove the instability of the A sequence, and prove that the special genetic structure of mice will make mice more adaptable to the environment and subtly change their own gene sequences under certain conditions, and after the change, it is not suitable for human drug experiments.

And how to find the reason for the instability of the mouse gene is what Bai Ye needs to consider now.

ps: Free word count, the recent addition is very poor, and the veteran once felt that he had collapsed and panicked.

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